Amyotrophic lateral sclerosis: Difference between revisions

	Amyotrophic lateral sclerosis;
	Stephen Hawking, a physicist who has ALS.
ICD-10	G12.2
ICD-9	335.20
OMIM	105400
DiseasesDB	29148
MedlinePlus	000688
MeSH	D000690

	Amyotrophic lateral sclerosis Microchapters
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Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Amyotrophic lateral sclerosis from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
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Physical Examination
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Treatment
Medical Therapy
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Case #1
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VisualWikitext

Latest revision as of 11:32, 2 July 2021

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohsen Basiri M.D.

Overview

Amyotrophic Lateral Sclerosis is a chronic progressive neurological disease that affects both upper and lower motor neurons. It presents with muscle spasms, fasciculation, weakness and which could ultimately lead to muscles paralysis. ALS is diagnosed clinically, however additional testing with electromyography to confirm muscle denervation. Laboratory tests might be required to rule out other reversible causes of weakness. ALS has a poor prognosis with death usually due to respiratory complications with a median survival of 3-5 years. ALS is managed by a multidisciplinary care setting with fewer disease modifying agents to date.

Historical Perspective

Amyotrophic Lateral Sclerosis was first described by French neurologist Jean-Martin Charcot in his Tuesday lectures in late 1860 and then a publication in 1874. He is also known as the Father of Amyotrophic Lateral Sclerosis because of his devotion to the disease. He complied 50 years of previous work on muscle weakness. He was the first scientist to link the disease to its specific pathology. ^[1]

Diagnosis

Treatment

Case Studies

Case #1

Related Chapters

References

↑ Katz JS, Dimachkie MM, Barohn RJ (2015). "Amyotrophic Lateral Sclerosis: A Historical Perspective". Neurol Clin. 33 (4): 727–34. doi:10.1016/j.ncl.2015.07.013. PMID 26515617.

Template:Diseases of the nervous system

Template:WS Template:WH

[pmid26515617-1] Katz JS, Dimachkie MM, Barohn RJ (2015). "Amyotrophic Lateral Sclerosis: A Historical Perspective". Neurol Clin. 33 (4): 727–34. doi:10.1016/j.ncl.2015.07.013. PMID 26515617.

[1]

@@ Line 1: / Line 1: @@
 __NOTOC__
+{{Amyotrophic lateral sclerosis}}
+{{CMG}}; {{AE}}{{M.B}}
 {{Infobox_Disease
   | Name           = Amyotrophic lateral sclerosis
@@ Line 12: / Line 15: @@
   | MeshID         = D000690
 }}
-{{Amyotrophic lateral sclerosis}}
-'''For patient information, click [[Amyotrophic lateral sclerosis (patient information)|here]]'''
-{{CMG}}
-{{SK}} ALS; Lou-Gehrig's disease; maladie de Charcot; upper and lower motor neuron disease; motor neuron disease
 ==[[Amyotrophic lateral sclerosis overview|Overview]]==
+Amyotrophic Lateral Sclerosis is a chronic progressive neurological disease that affects both upper and lower motor neurons. It presents with muscle spasms, fasciculation, weakness and which could ultimately lead to muscles paralysis. ALS is diagnosed clinically, however additional testing with electromyography to confirm muscle denervation. Laboratory tests might be required to rule out other reversible causes of weakness. ALS has a poor prognosis with death usually due to respiratory complications with a median survival of 3-5 years. ALS is managed by a multidisciplinary care setting with fewer disease modifying agents to date.
 ==[[Amyotrophic lateral sclerosis historical perspective|Historical Perspective]]==
+Amyotrophic Lateral Sclerosis was first described by French neurologist Jean-Martin Charcot in his Tuesday lectures in late 1860 and then a publication in 1874. He is also known as the ''' Father of Amyotrophic Lateral Sclerosis''' because of his devotion to the disease. He complied 50 years of previous work on muscle weakness. He was the first scientist to link the disease to its specific pathology.
+<ref name="pmid26515617">{{cite journal| author=Katz JS, Dimachkie MM, Barohn RJ| title=Amyotrophic Lateral Sclerosis: A Historical Perspective. | journal=Neurol Clin | year= 2015 | volume= 33 | issue= 4 | pages= 727-34 | pmid=26515617 | doi=10.1016/j.ncl.2015.07.013 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26515617  }} </ref>
 ==[[Amyotrophic lateral sclerosis classification|Classification]]==
@@ Line 35: / Line 34: @@
 ==[[Amyotrophic lateral sclerosis risk factors|Risk Factors]]==
+==[[Amyotrophic lateral sclerosis screening|Screening]]==
 ==[[Amyotrophic lateral sclerosis natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
 ==Diagnosis==
-[[Amyotrophic lateral sclerosis diagnostic evaluation|Diagnostic Evaluation]] | [[Amyotrophic lateral sclerosis history and symptoms|History and Symptoms]] | [[Amyotrophic lateral sclerosis physical examination|Physical Examination]] | [[Amyotrophic lateral sclerosis laboratory findings|Laboratory Findings]]
+[[Amyotrophic lateral sclerosis diagnostic evaluation|Diagnostic Evaluation]] | [[Amyotrophic lateral sclerosis history and symptoms|History and Symptoms]] | [[Amyotrophic lateral sclerosis physical examination|Physical Examination]] | [[Amyotrophic lateral sclerosis laboratory findings|Laboratory Findings]] | [[Amyotrophic lateral sclerosis electrocardiogram|Electrocardiogram]] | [[Amyotrophic lateral sclerosis x ray|X Ray]] | [[Amyotrophic lateral sclerosis CT|CT]] | [[Amyotrophic lateral sclerosis MRI|MRI]] | [[Amyotrophic lateral sclerosis echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Amyotrophic lateral sclerosis other imaging findings|Other Imaging Findings]] | [[Amyotrophic lateral sclerosis other diagnostic studies|Other Diagnostic Studies]]
-==Resources==
+==Treatment==
+[[Amyotrophic lateral sclerosis medical therapy|Medical Therapy]] | [[Amyotrophic lateral sclerosis surgery|Surgery]] | [[Amyotrophic lateral sclerosis primary prevention|Primary Prevention]] | [[Amyotrophic lateral sclerosis secondary prevention|Secondary Prevention]] | [[Amyotrophic lateral sclerosis cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Amyotrophic lateral sclerosis future or investigational therapies|Future or Investigational Therapies]]
-===United States===
+==Case Studies==
-* [http://www.neurology.emory.edu/als Emory ALS Center]
+[[Amyotrophic lateral sclerosis case study|Case #1]]
-* [[ALS Association]]
-* [[Muscular Dystrophy Association]] [http://www.als-mda.org]
-* [http://www.alscenter.org Packard Center for ALS Research at Johns Hopkins]
-* [[ALS Therapy Development Institute]] (ALS TDI), a non-profit biotechnology company focused on finding viable treatment and a cure
-===International===
+==Related Chapters==
-* [http://www.alsmndalliance.org ALS MND alliance]
-===United Kingdom===
+*[[Muscular Dystrophy Association]]
-* [http://www.mndassociation.org/ Motor Neurone Disease Association]
+*[[ALS Association]]
+*[[ALS Therapy Development Institute]]
-===Canada===
-* [http://www.als.ca/ ALS Society of Canada]
-===Australia===
-* Motor Neurone Disease Association of Australia [http://www.mndaust.asn.au/]
-==Awareness and fundraising events==
-* [http://www.rideforlife.com  The Ride For Life], founded in 1998 by ALS patient and former teacher Chris Pendergast. Chris and other ALS patients made a wheelchair ride from Yankee Stadium to Washington D.C.—a 350-mile journey. The ride continues annually and, in recent years, has centered on the New York Metro area. Their mission is to raise public awareness of ALS, help fund research, support ALS patients and their families, and provide the ALS community with the latest ALS related news, information and inspiration. Since 1998, Ride for Life has earned nearly 3 million dollars for ALS research and patient services.
-* Augie's Quest [http://www.augiesquest.org] was started by fitness pioneer Augie Nieto in cooperation with the Muscular Dystrophy Association after his diagnosis with the disease. Augie's Quest and [[ALS Therapy Development Institute|ALS TDI]] entered into the largest private funding collaboration in the history of the disease, $36 million, in 2006. All funds raised through Augie's Quest events go 100% to ALS research.
-* [http://www.alsa.org/walk/default.cfm?CFID=2221817&CFTOKEN=41813014 The Walk to D'Feet ALS] held annually by the ALS Association, where walkers raise awareness and money to fight and cure ALS.
-* [http://www.prize4life.org Prize 4 Life], a group of recent Harvard Business School graduates founded Prize4Life, a nonprofit to turbo charge ALS research because one or their classmates, Avi Kremer, MBA 2007 and Chairman of Prize4Life, was diagnosed with this fatal illness in the fall of 2004. Prize4Life is a results-oriented nonprofit founded to accelerate ALS/MND research by offering substantial prizes to scientists who solve the most critical scientific problems preventing the discovery of an effective ALS/MND treatment. The Prize4Life concept is inspired by other prize awards for stimulating research, such as the X-Prize for commercial space travel and DNA-decoding, the U.S. government’s H-Prize for hydrogen renewable energy, and Eli Lilly’s venture, InnoCentive, which outsources difficult R&D problems to a distributed network of scientists using prizes.
-==See also==
-* [[Muscular Dystrophy Association]]
-* [[ALS Association]]
-* [[ALS Therapy Development Institute]]
-==External links==
-*[http://www.3reasons.org A Ride for 3 Reasons] One man's solo ride across America on a bicycle to raise awareness and money for ALS research. Includes his daily weblog during the ride and profiles of families and individuals living with ALS.
-* [http://als.clinicahealth.com The ALS Advocacy Community] is the ALS Association's online community offering. Members can partake in blogs, discussions, social network and many other features.
-*[http://www.alsa.org ALS Association]
-* [http://www.als-project.com ALS-Project - Free communication software for people suffering from ALS]
-* [http://www.alsforums.com/ ALS Support Group] ALSforums is an international online support group for individuals affected by ALS (Lou Gehrig's Disease).
-*[http://www.als.net/forum/ ALS-TDF forums] are maintained by the ALS Therapy Development Foundation and focuses on answering scientific questions pertaining to ALS
-*[http://www.als.net ALS Therapy Development Foundation]; see also ''So Much So Fast'' below
-*[http://www.alswarriorpoet.com ALS Warrior Poet] Blazeman Foundation, founded by the late Job Blaise, the first person with ALS to compete and finish the Ironman triathalon.
-*[http://www.alsa.org/patient/drug.cfm?id=46 Clinical Trial of Neurodex for Pseudobulbar Affect in People with Amyotrophic Lateral Sclerosis]
-*[http://brain.hastypastry.net/forums/forumdisplay.php?f=77 BrainTalk communities] was one of the largest ALS/MND forums in the world but following a 2-month hardware failure is currently rebuilding its community.
-*[http://www.build-uk.net BUILD UK] is for people affected by ALS/MND in the UK, but also has overseas members
-*[http://www.dukealsclinic.com Duke ALS Clinic] The Muscular Dystrophy Association (MDA) has recognized the Duke ALS Clinic as one of its distinguished ALS Research and Clinical Centers.
-*[http://www.extrahands.org Extra Hands for ALS]
-*[http://www.lesturnerals.org Les Turner ALS Foundation]
-* [http://www.lougehrig.com Lou Gehrig's Website]
-*[http://www.misaoforacause.com Misao for a Cause] A t-shirt charity created by Misao Apparel, to help benefit those diagnosed with ALS.
-*[http://www.patientslikeme.com PatientsLikeMe] is a telesocial medicine site which allows ALS/MND patients to record their symptoms and share information about treatments
-*[http://www.alscenter.org Robert Packard Center for ALS Research at Johns Hopkins, a leader in ALS Research]
-*[http://www.westcityfilms.com/smsf.html So Much So Fast]  A documentary about ALS and one family's race to find a cure; aired on [http://www.pbs.org/wgbh/pages/frontline/somuchsofast/ PBS's Frontline] in May 2007
-*[http://www.hawking.org.uk/home/hindex.html Stephen Hawking's Website]
-*[http://www.patrickobrienfoundation.org/ The Patrick O'Brien Foundation] A non-profit dedicated to promoting awareness of ALS, established in honor of Patrick Sean O'Brien - an artist diagnosed with ALS at the uncommonly early age of 30, who is chronicling his experience of the disease for a feature film.
-*[http://www.waronals.com War on ALS] Official Site of Team Blazeman, founded in honor of the late Jon Blais.
 ==References==
-{{Reflist|2}}
+{{reflist|2}}
-== General Muscular Dystrophy ==
+{{Diseases of the  nervous system}}
-*[http://www.mdaeurope.org Muscular Dystrophy Association Europe]
-''This article incorporates  in public domain text from [http://www.ninds.nih.gov/ The U.S. National Institute of Neurological Disorders and Stroke]'' <br>
+[[Category:Neurology]]
-{{Diseases of the  nervous system}}
+{{WS}}
 {{WH}}
-{{WS}}
-[[Category:Motor neuron disease]]
-[[Category:Neurology]]
-[[Category:Disease]]
-[[Category:Overview complete]]


Amyotrophic lateral sclerosis
Stephen Hawking, a physicist who has ALS.
ICD-10	G12.2
ICD-9	335.20
OMIM	105400
DiseasesDB	29148
MedlinePlus	000688
MeSH	D000690