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==Overview==
The most potent risk factor in the development of central pontine myelinolysis is [[hyponatremia]]. Other risk factors include: Liver dysfunction and [[liver diseases]], [[hypocholesterolemia]], [[alcoholism]], [[malnutrition]], systemic medical disease and [[hemodialysis]].


==Overview==
==Risk Factors==
It has been postulated that one underlying cause may be the lack of a substance that is essential for brain activity and is lacking due to [[malnutrition]]. The fact that this condition is most frequently observed in patients with general ill health ([[alcoholism]], [[cachexia]] etc.) is in accordance with this hypothesis. <ref>Adams RA, Victor M, Mancall EL. Central pontine myelinolysis: a hitherto undescribed disease occurring in alcoholics and malnourished patients. ''Arch Neurol Psychiatry.'' 1959;81:154–72PMID 13616772</ref>
===Common Risk Factors===
*The most potent risk factor in the development of central pontine myelinolysis is [[hyponatremia]].
*Other risk factors include:<ref name="pmid19797900">{{cite journal| author=Lee EM, Kang JK, Yun SC, Kim KH, Kim SJ, Hwang KS et al.| title=Risk factors for central pontine and extrapontine myelinolysis following orthotopic liver transplantation. | journal=Eur Neurol | year= 2009 | volume= 62 | issue= 6 | pages= 362-8 | pmid=19797900 | doi=10.1159/000242426 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19797900  }} </ref><ref name="pmid24716023">{{cite journal| author=Jacob S, Gupta H, Nikolic D, Gundogdu B, Ong S| title=Central pontine and extrapontine myelinolysis: the great masquerader-an autopsy case report. | journal=Case Rep Neurol Med | year= 2014 | volume= 2014 | issue=  | pages= 745347 | pmid=24716023 | doi=10.1155/2014/745347 | pmc=3970353 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24716023  }} </ref><ref name="pmid15316041">{{cite journal| author=Martin RJ| title=Central pontine and extrapontine myelinolysis: the osmotic demyelination syndromes. | journal=J Neurol Neurosurg Psychiatry | year= 2004 | volume= 75 Suppl 3 | issue=  | pages= iii22-8 | pmid=15316041 | doi=10.1136/jnnp.2004.045906 | pmc=1765665 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15316041 }} </ref><ref name="pmid12535304">{{cite journal| author=Oo TN, Smith CL, Swan SK| title=Does uremia protect against the demyelination associated with correction of hyponatremia during hemodialysis? A case report and literature review. | journal=Semin Dial | year= 2003 | volume= 16 | issue= 1 | pages= 68-71 | pmid=12535304 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12535304  }} </ref>
**[[Liver dysfunction]] and [[liver diseases]]
**[[Hypocholesterolemia]]
**[[Alcoholism]]
**[[Malnutrition]]
**Systemic medical disease
**[[Hemodialysis]]


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


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Latest revision as of 03:56, 15 August 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Overview

The most potent risk factor in the development of central pontine myelinolysis is hyponatremia. Other risk factors include: Liver dysfunction and liver diseases, hypocholesterolemia, alcoholism, malnutrition, systemic medical disease and hemodialysis.

Risk Factors

Common Risk Factors

References

  1. Lee EM, Kang JK, Yun SC, Kim KH, Kim SJ, Hwang KS; et al. (2009). "Risk factors for central pontine and extrapontine myelinolysis following orthotopic liver transplantation". Eur Neurol. 62 (6): 362–8. doi:10.1159/000242426. PMID 19797900.
  2. Jacob S, Gupta H, Nikolic D, Gundogdu B, Ong S (2014). "Central pontine and extrapontine myelinolysis: the great masquerader-an autopsy case report". Case Rep Neurol Med. 2014: 745347. doi:10.1155/2014/745347. PMC 3970353. PMID 24716023.
  3. Martin RJ (2004). "Central pontine and extrapontine myelinolysis: the osmotic demyelination syndromes". J Neurol Neurosurg Psychiatry. 75 Suppl 3: iii22–8. doi:10.1136/jnnp.2004.045906. PMC 1765665. PMID 15316041.
  4. Oo TN, Smith CL, Swan SK (2003). "Does uremia protect against the demyelination associated with correction of hyponatremia during hemodialysis? A case report and literature review". Semin Dial. 16 (1): 68–71. PMID 12535304.

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