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{{Autoimmune hepatitis}}
{{Autoimmune hepatitis}}
{{CMG}}
{{CMG}}; {{AE}} {{MKK}},  {{ADI}}
 
==Overview==
Autoimmune hepatitis may be caused by the Drugs like  [[minocycline]], [[nitrofurantoin]], [[hydralazine]], [[methyldopa]], [[statins]], [[fenofibrate]], [[interferon]], [[infliximab]], [[etanercept]], viral infections e.g [[measles virus]], [[Epstein Barr virus|EB]] virus, [[cytomegalovirus infection|CMV]] and [[hepatitis]] A, B, C, D, E and if there is the history of other autoimmune diseases e.g [[graves disease]], [[inflammatory bowel disease]], [[rheumatoid arthritis]], [[scleroderma]], [[Sjogren syndrome]], [[systemic lupus erythematosus]], [[thyroiditis]], [[type 1 diabetes]], [[ulcerative colitis]].


==Causes==
==Causes==
===Common Causes===
*Drugs <ref name="urlAutoimmune Hepatitis">{{cite web |url=http://livertox.nih.gov/Phenotypes_auto.html |title=Autoimmune Hepatitis |format= |work= |accessdate=2013-01-02}}</ref>
** [[Minocycline]]
** [[Nitrofurantoin]]
** [[Hydralazine]]
** [[Methyldopa]]
** [[Statins]]
** [[Fenofibrate]]
** [[Interferon]]
** [[Infliximab]]
** [[Etanercept]]
*History of viral infections:
**[[Measles]] [[Viruses|viruse]]
**[[Cytomegalovirus]]
**[[Epstein Barr virus|Epstein–Barr virus]]
**[[Hepatitis]] A, B, C, D, E.
*History of autoimmune disease:<ref name="urlAutoimmune hepatitis - PubMed Health">{{cite web |url=http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001291/#adam_000245.disease.causes |title=Autoimmune hepatitis - PubMed Health |format= |work= |accessdate=2013-01-02}}</ref>
**[[Graves disease]]
**[[Inflammatory bowel disease]]
**[[Rheumatoid arthritis]]
**[[Scleroderma]]
**[[Sjogren syndrome]]
**[[Systemic lupus erythematosus]]
**[[Thyroiditis]]
**[[Type 1 diabetes]]
**[[Ulcerative colitis]]
===Causes by Organ System===
{| style="width:75%; height:100px" border="1"
| style="width:25%" bgcolor="LightSteelBlue" ; border="1" | '''Cardiovascular'''
| style="width:75%" bgcolor="Beige" ; border="1" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Chemical / poisoning'''
| bgcolor="Beige" | [[Morinda citrifolia]] ([[Noni juice]]), Dai-saiko-to <ref name="pmid9128330">{{cite journal |author=Kamiyama T, Nouchi T, Kojima S, Murata N, Ikeda T, Sato C |title=Autoimmune hepatitis triggered by administration of an herbal medicine |journal=[[The American Journal of Gastroenterology]] |volume=92 |issue=4 |pages=703–4 |year=1997 |month=April |pmid=9128330 |doi= |url= |accessdate=2013-01-02}}</ref>, [[Germander]], [[Herbalism|Herbal compounds]], [[Toxic mushrooms]] ([[Mycotoxins|cyclopeptides]])
|-
|- bgcolor="LightSteelBlue"
| '''Dermatologic'''
| bgcolor="Beige" | [[Scleroderma]], [[Systemic lupus erythematosus]]
|-
|- bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| bgcolor="Beige" | [[3,4-methylenedioxymetamphetamine]], [[Alpha interferon]], [[Beta interferon]], [[Methyldopa]], [[Minocycline ]] , [[Ecstasy]], [[Artorvastatin]], [[Atomexitine ]] , [[Carboxymethyl cellulose ]] , Clometacine <ref name="pmid3391074">{{cite journal |author=Hillon P, Bedenne L, Piard F, Regis P |title=Clometacine-induced hepatitis |journal=[[Digestive Diseases and Sciences]] |volume=33 |issue=8 |pages=1045–6 |year=1988 |month=August |pmid=3391074 |doi= |url= |accessdate=2013-01-02}}</ref>, [[Diclofenac ]] , [[Dioctyl sodium sulfosuccinate]], [[Doxycycline]], [[Etanercept]], [[Fenofibrate]], [[Hydralazine]], [[Infliximab]], [[Interferon ]] , [[Nitrofurantoin]], [[Oxyphenisatin]], [[Papaverine]],[[Peginterferon Beta-1a]],[[Pemoline]],[[Phenprocoumon]], [[Pyrazinamide]], [[Rifampin]], [[Rosuvastatin]], [[Simvastatin ]] , [[Twinrix]]
|-
|- bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Endocrine'''
| bgcolor="Beige" | [[Graves disease]], [[Polyendocrine deficiency syndrome type 1]], [[Thyroiditis]], [[Type 1 diabetes]]
|-
|- bgcolor="LightSteelBlue"
| '''Environmental'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
| bgcolor="Beige" | [[Inflammatory bowel disease]], [[Ulcerative colitis]]
|-
|- bgcolor="LightSteelBlue"
| '''Genetic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Hematologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Iatrogenic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Infectious Disease'''
| bgcolor="Beige" | [[Measles]] [[Viruses|viruse]], [[Cytomegalovirus]], and [[Epstein Barr virus|Epstein–Barr virus]]
|-
|- bgcolor="LightSteelBlue"
| '''Musculoskeletal / Ortho'''
| bgcolor="Beige" | [[Rheumatoid arthritis]],
|-
|- bgcolor="LightSteelBlue"
| '''Neurologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Nutritional / Metabolic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Oncologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Opthalmologic'''
| bgcolor="Beige" | [[Grave's disease]], [[Sjogren syndrome]]
|-
|- bgcolor="LightSteelBlue"
| '''Overdose / Toxicity'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Psychiatric'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Pulmonary'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Renal / Electrolyte'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Rheum / Immune / Allergy'''
| bgcolor="Beige" | [[Rheumatoid arthritis]], [[Graves disease]], [[Inflammatory bowel disease]], [[Polyendocrine deficiency syndrome type 1]], [[Scleroderma]], [[Sjogren syndrome]], [[Systemic lupus erythematosus]], [[Thyroiditis]], [[Type 1 diabetes]], [[Ulcerative colitis]]
|-
|- bgcolor="LightSteelBlue"
| '''Sexual'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Trauma'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Urologic'''
| bgcolor="Beige" | No underlying causes
|-
|- bgcolor="LightSteelBlue"
| '''Miscellaneous'''
| bgcolor="Beige" | No underlying causes
|-
|}
===Causes in Alphabetical Order===
* [[3,4-methylenedioxymetamphetamine]]<ref name="pmid7797836">{{cite journal |author=Khakoo SI, Coles CJ, Armstrong JS, Barry RE |title=Hepatotoxicity and accelerated fibrosis following 3,4-methylenedioxymetamphetamine ("ecstasy") usage |journal=[[Journal of Clinical Gastroenterology]] |volume=20 |issue=3 |pages=244–7 |year=1995 |month=April |pmid=7797836 |doi= |url=}}</ref>
* [[Alpha interferon]] <ref name="pmid1445668">{{cite journal |author=Ariad S, Song E, Cohen R, Bezwoda WR |title=Interferon-alpha induced autoimmune hepatitis in a patient with Philadelphia chromosome-positive chronic myeloid leukemia with cytogenetically normal T lymphocytes |journal=[[Molecular Biotherapy]] |volume=4 |issue=3 |pages=139–42 |year=1992 |month=September |pmid=1445668 |doi= |url=}}</ref>
* [[Atorvastatin]]
* [[Atomexitine ]]
* [[Beta interferon]] <ref name="urlINTERFERON">{{cite web |url=http://livertox.nlm.nih.gov/Interferon.htm |title=INTERFERON |format= |work= |accessdate=}}</ref>
* [[Carboxymethyl cellulose ]]
* Clometacine
* Dai-saiko-to
* [[Diclofenac ]]
* [[Dioctyl sodium sulfosuccinate]]
* [[Doxycycline ]]
* [[Ecstasy]]<ref name="pmid7797836">{{cite journal |author=Khakoo SI, Coles CJ, Armstrong JS, Barry RE |title=Hepatotoxicity and accelerated fibrosis following 3,4-methylenedioxymetamphetamine ("ecstasy") usage |journal=[[Journal of Clinical Gastroenterology]] |volume=20 |issue=3 |pages=244–7 |year=1995 |month=April |pmid=7797836 |doi= |url=}}</ref>
* [[Etanercept]]
* [[Fenofibrate]]
* [[Germander]] <ref name="pmid18608288">{{cite journal |author=Poon WT, Chau TL, Lai CK, Tse KY, Chan YC, Leung KS, Chan YW |title=Hepatitis induced by Teucrium viscidum |journal=[[Clinical Toxicology (Philadelphia, Pa.)]] |volume=46 |issue=9 |pages=819–22 |year=2008 |month=November |pmid=18608288 |doi=10.1080/15563650701739590 |url=http://informahealthcare.com/doi/abs/10.1080/15563650701739590 |accessdate=2013-01-02}}</ref>
* [[Graves disease]]
* [[Herbalism|Herbal compounds]]
* [[Hydralazine]]
* [[Inflammatory bowel disease]]
* [[Infliximab]]
* [[Interferon ]]
* [[Methyldopa]]
* [[Minocycline]]
* [[Minocycline ]]
* [[Morinda citrifolia]] ([[Noni juice]])
* [[Nitrofurantoin]]
* [[Oxyphenisatin]] <ref name="pmid3241981">{{cite journal |author=Teh LB, Chong R, Ho JM, Ong YY |title=Oxyphenisatin induced chronic active hepatitis--a potential health hazard in Singapore |journal=[[Singapore Medical Journal]] |volume=29 |issue=5 |pages=508–12 |year=1988 |month=October |pmid=3241981 |doi= |url= |accessdate=2013-01-02}}</ref>
* [[Peginterferon Beta-1a]]
* [[Papaverine]]
* [[Pemoline]]
* [[Phenprocoumon]] <ref name="pmid15246210">{{cite journal |author=Schimanski CC, Burg J, Möhler M, Höhler T, Kanzler S, Otto G, Galle PR, Lohse AW |title=Phenprocoumon-induced liver disease ranges from mild acute hepatitis to (sub-) acute liver failure |journal=[[Journal of Hepatology]] |volume=41 |issue=1 |pages=67–74 |year=2004 |month=July |pmid=15246210 |doi=10.1016/j.jhep.2004.03.010 |url=http://linkinghub.elsevier.com/retrieve/pii/S0168827804001059 |accessdate=2013-01-02}}</ref>
* [[Polyendocrine deficiency syndrome type 1]]
* [[Pyrazinamide]]
* [[Rheumatoid arthritis]]
* [[Rifampin]]
* [[Rosuvastatin]]
* [[Scleroderma]]
* [[Simvastatin ]]
* [[Sjogren syndrome]]
* [[Systemic lupus erythematosus]]
* [[Thyroiditis]]
* [[Toxic mushrooms]] ([[Mycotoxins|cyclopeptides]])
* [[Twinrix]] <ref name="pmid17448944">{{cite journal |author=Van Herck K, Leroux-Roels G, Van Damme P, Srinivasa K, Hoet B |title=Ten-year antibody persistence induced by hepatitis A and B vaccine (Twinrix) in adults |journal=[[Travel Medicine and Infectious Disease]] |volume=5 |issue=3 |pages=171–5 |year=2007 |month=May |pmid=17448944 |doi=10.1016/j.tmaid.2006.07.003 |url= |accessdate=2013-01-02}}</ref>
* [[Type 1 diabetes]]
* [[Ulcerative colitis]]


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
[[Category:Needs content]]
 
[[Category:Disease]]
[[Category:Disease]]
[[Category:Gastroenterology]]
[[Category:Gastroenterology]]
[[Category:Needs overview]]
[[Category:Needs overview]]
[[Category:Needs causes]]
[[Category:Hepatology]]
 
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{{WH}}

Latest revision as of 17:01, 9 January 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2], Aditya Govindavarjhulla, M.B.B.S. [3]

Overview

Autoimmune hepatitis may be caused by the Drugs like minocycline, nitrofurantoin, hydralazine, methyldopa, statins, fenofibrate, interferon, infliximab, etanercept, viral infections e.g measles virus, EB virus, CMV and hepatitis A, B, C, D, E and if there is the history of other autoimmune diseases e.g graves disease, inflammatory bowel disease, rheumatoid arthritis, scleroderma, Sjogren syndrome, systemic lupus erythematosus, thyroiditis, type 1 diabetes, ulcerative colitis.

Causes

Common Causes

Causes by Organ System

Cardiovascular No underlying causes
Chemical / poisoning Morinda citrifolia (Noni juice), Dai-saiko-to [3], Germander, Herbal compounds, Toxic mushrooms (cyclopeptides)
Dermatologic Scleroderma, Systemic lupus erythematosus
Drug Side Effect 3,4-methylenedioxymetamphetamine, Alpha interferon, Beta interferon, Methyldopa, Minocycline , Ecstasy, Artorvastatin, Atomexitine , Carboxymethyl cellulose , Clometacine [4], Diclofenac , Dioctyl sodium sulfosuccinate, Doxycycline, Etanercept, Fenofibrate, Hydralazine, Infliximab, Interferon , Nitrofurantoin, Oxyphenisatin, Papaverine,Peginterferon Beta-1a,Pemoline,Phenprocoumon, Pyrazinamide, Rifampin, Rosuvastatin, Simvastatin , Twinrix
Ear Nose Throat No underlying causes
Endocrine Graves disease, Polyendocrine deficiency syndrome type 1, Thyroiditis, Type 1 diabetes
Environmental No underlying causes
Gastroenterologic Inflammatory bowel disease, Ulcerative colitis
Genetic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease Measles viruse, Cytomegalovirus, and Epstein–Barr virus
Musculoskeletal / Ortho Rheumatoid arthritis,
Neurologic No underlying causes
Nutritional / Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Opthalmologic Grave's disease, Sjogren syndrome
Overdose / Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal / Electrolyte No underlying causes
Rheum / Immune / Allergy Rheumatoid arthritis, Graves disease, Inflammatory bowel disease, Polyendocrine deficiency syndrome type 1, Scleroderma, Sjogren syndrome, Systemic lupus erythematosus, Thyroiditis, Type 1 diabetes, Ulcerative colitis
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order

  • Clometacine
  • Dai-saiko-to

References

  1. ↑ "Autoimmune Hepatitis". Retrieved 2013-01-02.
  2. ↑ "Autoimmune hepatitis - PubMed Health". Retrieved 2013-01-02.
  3. ↑ Kamiyama T, Nouchi T, Kojima S, Murata N, Ikeda T, Sato C (1997). "Autoimmune hepatitis triggered by administration of an herbal medicine". The American Journal of Gastroenterology. 92 (4): 703–4. PMID 9128330. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)
  4. ↑ Hillon P, Bedenne L, Piard F, Regis P (1988). "Clometacine-induced hepatitis". Digestive Diseases and Sciences. 33 (8): 1045–6. PMID 3391074. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)
  5. ↑ 5.0 5.1 Khakoo SI, Coles CJ, Armstrong JS, Barry RE (1995). "Hepatotoxicity and accelerated fibrosis following 3,4-methylenedioxymetamphetamine ("ecstasy") usage". Journal of Clinical Gastroenterology. 20 (3): 244–7. PMID 7797836. Unknown parameter |month= ignored (help)
  6. ↑ Ariad S, Song E, Cohen R, Bezwoda WR (1992). "Interferon-alpha induced autoimmune hepatitis in a patient with Philadelphia chromosome-positive chronic myeloid leukemia with cytogenetically normal T lymphocytes". Molecular Biotherapy. 4 (3): 139–42. PMID 1445668. Unknown parameter |month= ignored (help)
  7. ↑ "INTERFERON".
  8. ↑ Poon WT, Chau TL, Lai CK, Tse KY, Chan YC, Leung KS, Chan YW (2008). "Hepatitis induced by Teucrium viscidum". Clinical Toxicology (Philadelphia, Pa.). 46 (9): 819–22. doi:10.1080/15563650701739590. PMID 18608288. Retrieved 2013-01-02. Unknown parameter |month= ignored (help)
  9. ↑ Teh LB, Chong R, Ho JM, Ong YY (1988). "Oxyphenisatin induced chronic active hepatitis--a potential health hazard in Singapore". Singapore Medical Journal. 29 (5): 508–12. PMID 3241981. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)
  10. ↑ Schimanski CC, Burg J, Möhler M, Höhler T, Kanzler S, Otto G, Galle PR, Lohse AW (2004). "Phenprocoumon-induced liver disease ranges from mild acute hepatitis to (sub-) acute liver failure". Journal of Hepatology. 41 (1): 67–74. doi:10.1016/j.jhep.2004.03.010. PMID 15246210. Retrieved 2013-01-02. Unknown parameter |month= ignored (help)
  11. ↑ Van Herck K, Leroux-Roels G, Van Damme P, Srinivasa K, Hoet B (2007). "Ten-year antibody persistence induced by hepatitis A and B vaccine (Twinrix) in adults". Travel Medicine and Infectious Disease. 5 (3): 171–5. doi:10.1016/j.tmaid.2006.07.003. PMID 17448944. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)

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