Atrial septal defect ostium secundum pathophysiology: Difference between revisions
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Latest revision as of 02:18, 15 March 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Although atrial septal defect ostium secundum defects occur sporadically, they are associated with and occur with higher frequency in certain genetic disorders.
Pathophysiology
Associated Conditions
Most of ostium secundum ASDs occur sporadically. However, ostium secundum ASD has been found to occur with increased frequency in association with some genetic disorders including:
- Holt-Oram (heart-hand) syndrome
- Down syndrome
- Noonan syndrome
- Treacher Collins syndrome
- Thrombocytopenia-absent radii (TAR) syndrome
- Mitral valve prolapse: 10% to 20 % of individuals with ostium secundum ASDs also have mitral valve prolapse.[1]
References
- ↑ Leachman R, Cokkinos D, Cooley D (1976). "Association of ostium secundum atrial septal defects with mitral valve prolapse". Am J Cardiol. 38 (2): 167–9. PMID 952260.