Atherosclerosis causes: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{xyz}} | |||
{{CMG}}; {{AE}}{{NE}} | |||
{{Atherosclerosis}} | {{Atherosclerosis}} | ||
==Overview== | |||
Atherosclerosis may be caused by inflamation,immunity or infection.Atherosclerosis is a disease with multiple genetic and environmental contributions. To review risk factors for the development of atherosclerosis, click [[atherosclerosis risk factor#Overview|here]]. | |||
==Causes== | |||
===Life-threatening Causes=== | |||
*Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.complications resulting from untreated atherosclerosis is common. | |||
*Atherosclerosis is a life-threatening cause of acute cronary syndrome and stroke. | |||
===Common Causes=== | |||
Common causes of atherosclerosis may include: | |||
*Immunity | |||
*Inflamation | |||
*Infections,such as geram negative sepsis,can cause type 2 acute cronary syndrome.<ref name="pmid30336831">{{cite journal| author=Libby P, Loscalzo J, Ridker PM, Farkouh ME, Hsue PY, Fuster V | display-authors=etal| title=Inflammation, Immunity, and Infection in Atherothrombosis: JACC Review Topic of the Week. | journal=J Am Coll Cardiol | year= 2018 | volume= 72 | issue= 17 | pages= 2071-2081 | pmid=30336831 | doi=10.1016/j.jacc.2018.08.1043 | pmc=6196735 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30336831 }} </ref> | |||
*Smoking | |||
*HTN | |||
*HLP | |||
*DM | |||
*Kidney disease | |||
*Adiposity<ref name="pmiddoi.org/10.1161">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=doi.org/10.1161 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10 }} </ref> | |||
===Less Common Causes=== | |||
Less common causes of [disease name] include: | |||
*[Cause1] | |||
*[Cause2] | |||
*[Cause3] | |||
===Genetic Causes=== | |||
*Atherosclerosis can caused by expression in the PCSK9 gene.<ref name="pmid22176652">{{cite journal| author=Ferri N, Tibolla G, Pirillo A, Cipollone F, Mezzetti A, Pacia S | display-authors=etal| title=Proprotein convertase subtilisin kexin type 9 (PCSK9) secreted by cultured smooth muscle cells reduces macrophages LDLR levels. | journal=Atherosclerosis | year= 2012 | volume= 220 | issue= 2 | pages= 381-6 | pmid=22176652 | doi=10.1016/j.atherosclerosis.2011.11.026 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22176652 }} </ref> | |||
*Mutation one of the three genes below can cause familal hypercholesterolemia:LDLR,APOB3,PCSK9.<ref name="pmid24585268">{{cite journal| author=Sjouke B, Kusters DM, Kindt I, Besseling J, Defesche JC, Sijbrands EJ | display-authors=etal| title=Homozygous autosomal dominant hypercholesterolaemia in the Netherlands: prevalence, genotype-phenotype relationship, and clinical outcome. | journal=Eur Heart J | year= 2015 | volume= 36 | issue= 9 | pages= 560-5 | pmid=24585268 | doi=10.1093/eurheartj/ehu058 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24585268 }} </ref> | |||
*In human nearly 40 quantitative trait loci have been found for atherosclerosis.<ref name="pmid17767904">{{cite journal| author=Chen Y, Rollins J, Paigen B, Wang X| title=Genetic and genomic insights into the molecular basis of atherosclerosis. | journal=Cell Metab | year= 2007 | volume= 6 | issue= 3 | pages= 164-79 | pmid=17767904 | doi=10.1016/j.cmet.2007.07.001 | pmc=2083632 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17767904 }} </ref> | |||
===Causes by Organ System=== | |||
{|style="width:80%; height:100px" border="1" | |||
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular''' | |||
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | No underlying causes | |||
|- | |||
|bgcolor="LightSteelBlue"| '''Chemical/Poisoning''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Dental''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Dermatologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Drug Side Effect''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Ear Nose Throat''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Endocrine''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Environmental''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Gastroenterologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Genetic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Hematologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Iatrogenic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Infectious Disease''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Musculoskeletal/Orthopedic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Neurologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Nutritional/Metabolic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Obstetric/Gynecologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Oncologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Ophthalmologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Overdose/Toxicity''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Psychiatric''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Pulmonary''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Renal/Electrolyte''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Rheumatology/Immunology/Allergy''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Sexual''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Trauma''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Urologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Miscellaneous''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|} | |||
===Causes in Alphabetical Order=== | |||
List the causes of the disease in alphabetical order: | |||
<div style="-moz-column-count:3; column-count:3;"> | |||
* Cause 1 | |||
* Cause 2 | |||
* Cause 3 | |||
* Cause 4 | |||
* Cause 5 | |||
* Cause 6 | |||
* Cause 7 | |||
* Cause 8 | |||
* Cause 9 | |||
* Cause 10 | |||
</div> | |||
==References== | ==References== | ||
| Line 8: | Line 170: | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[CME Category::Cardiology]] | |||
[[Category:Needs content]] | [[Category:Needs content]] | ||
[[Category:Angiology]] | [[Category:Angiology]] | ||
[[Category:Cardiology]] | [[Category:Cardiology]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
Latest revision as of 20:31, 29 July 2020
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Xyz Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Atherosclerosis causes On the Web |
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American Roentgen Ray Society Images of Atherosclerosis causes |
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Risk calculators and risk factors for Atherosclerosis causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Niloofarsadaat Eshaghhosseiny, MD[2]
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Atherosclerosis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
ACC/AHA Guideline Recommendations |
|
Case Studies |
|
Atherosclerosis causes On the Web |
|
American Roentgen Ray Society Images of Atherosclerosis causes |
|
Risk calculators and risk factors for Atherosclerosis causes |
Overview
Atherosclerosis may be caused by inflamation,immunity or infection.Atherosclerosis is a disease with multiple genetic and environmental contributions. To review risk factors for the development of atherosclerosis, click here.
Causes
Life-threatening Causes
- Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.complications resulting from untreated atherosclerosis is common.
- Atherosclerosis is a life-threatening cause of acute cronary syndrome and stroke.
Common Causes
Common causes of atherosclerosis may include:
- Immunity
- Inflamation
- Infections,such as geram negative sepsis,can cause type 2 acute cronary syndrome.[1]
- Smoking
- HTN
- HLP
- DM
- Kidney disease
- Adiposity[2]
Less Common Causes
Less common causes of [disease name] include:
- [Cause1]
- [Cause2]
- [Cause3]
Genetic Causes
- Atherosclerosis can caused by expression in the PCSK9 gene.[3]
- Mutation one of the three genes below can cause familal hypercholesterolemia:LDLR,APOB3,PCSK9.[4]
- In human nearly 40 quantitative trait loci have been found for atherosclerosis.[5]
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | No underlying causes |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | No underlying causes |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
List the causes of the disease in alphabetical order:
- Cause 1
- Cause 2
- Cause 3
- Cause 4
- Cause 5
- Cause 6
- Cause 7
- Cause 8
- Cause 9
- Cause 10
References
- ↑ Libby P, Loscalzo J, Ridker PM, Farkouh ME, Hsue PY, Fuster V; et al. (2018). "Inflammation, Immunity, and Infection in Atherothrombosis: JACC Review Topic of the Week". J Am Coll Cardiol. 72 (17): 2071–2081. doi:10.1016/j.jacc.2018.08.1043. PMC 6196735. PMID 30336831.
- ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID doi.org/10.1161 Check
|pmid=value (help). - ↑ Ferri N, Tibolla G, Pirillo A, Cipollone F, Mezzetti A, Pacia S; et al. (2012). "Proprotein convertase subtilisin kexin type 9 (PCSK9) secreted by cultured smooth muscle cells reduces macrophages LDLR levels". Atherosclerosis. 220 (2): 381–6. doi:10.1016/j.atherosclerosis.2011.11.026. PMID 22176652.
- ↑ Sjouke B, Kusters DM, Kindt I, Besseling J, Defesche JC, Sijbrands EJ; et al. (2015). "Homozygous autosomal dominant hypercholesterolaemia in the Netherlands: prevalence, genotype-phenotype relationship, and clinical outcome". Eur Heart J. 36 (9): 560–5. doi:10.1093/eurheartj/ehu058. PMID 24585268.
- ↑ Chen Y, Rollins J, Paigen B, Wang X (2007). "Genetic and genomic insights into the molecular basis of atherosclerosis". Cell Metab. 6 (3): 164–79. doi:10.1016/j.cmet.2007.07.001. PMC 2083632. PMID 17767904.