Lactic acidosis causes: Difference between revisions
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==Overview== | ==Overview== | ||
Lactic acidosis is one of the most common causes of high [[anion gap]] [[metabolic acidosis]] and is usually associated with a serum [[lactate]] levels above 4 mmol/L. Reduced oxygen tension shunts [[glycolysis]] towards [[pyruvate]] production, which in turn leads to lactate accumulation since pyruvate can no longer undergo [[aerobic metabolism]]. | Lactic acidosis is one of the most common causes of high [[anion gap]] [[metabolic acidosis]] and is usually associated with a serum [[lactate]] levels above 4 mmol/L. Reduced oxygen tension shunts [[glycolysis]] towards [[pyruvate]] production, which in turn leads to lactate accumulation since pyruvate can no longer undergo [[aerobic metabolism]]. | ||
==Causes== | ==Causes== | ||
===Life Threatening Causes=== | ===Life Threatening Causes=== | ||
Life-threatening causes include conditions which result in death or permanent disability within 24 hours if left untreated. | |||
*[[Cardiac arrest]] | *[[Cardiac arrest]] | ||
*[[Mesenteric ischemia]] | *[[Mesenteric ischemia]] | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Drug Side Effect''' | | '''Drug Side Effect''' | ||
|bgcolor="Beige"| [[Abacavir]], [[adefovir]], [[atenolol]], [[biguanide]], [[buformin]], [[didanosine]], [[emtricitabine]], [[entecavir]], [[lamivudine]], [[linezolid]], [[metformin]], [[paracetamol]], [[phenformin]], | |bgcolor="Beige"| [[Abacavir]], [[adefovir]], [[atenolol]], [[biguanide]], [[buformin]], [[didanosine]], [[emtricitabine]], [[entecavir]], [[Glyburide and Metformin]], [[lamivudine]], [[Linagliptin and Metformin hydrochloride]], [[linezolid]], [[metformin]], [[paracetamol]], [[phenformin]], [[Repaglinide and Metformin hydrochloride]], [[Reye's syndrome]], [[salicylate intoxication]], [[Saxagliptin hydrochloride and Metformin hydrochloride]], [[stavudine]], [[strychnine]], [[telbivudine]], [[tenofovir]], [[zalcitabine]], [[Zidovudine]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Gastroenterologic''' | | '''Gastroenterologic''' | ||
|bgcolor="Beige"| [[Acute liver failure]], [[intestinal ischemia]], [[liver failure]], [[mesenteric ischemia]], [[short bowel syndrome]] | |bgcolor="Beige"| [[Acute liver failure]], [[intestinal ischemia]], [[liver failure]], [[mesenteric ischemia]], [[short bowel syndrome]], [[small bowel bacterial overgrowth]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Infectious Disease''' | | '''Infectious Disease''' | ||
|bgcolor="Beige"| [[Acquired immune deficiency syndrome]], [[sepsis]] | |bgcolor="Beige"| [[Acquired immune deficiency syndrome]], [[sepsis]], [[small bowel bacterial overgrowth]] | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Miscellaneous''' | | '''Miscellaneous''' | ||
|bgcolor="Beige"| [[ | |bgcolor="Beige"|[[Chronic fatigue syndrome]], [[coenzyme Q10|coenzyme q10 deficiency]], [[exercise]], [[glycogen storage disease]], [[hypothermia]], [[idiopathic]], [[malignant hyperpyrexia]], [[mitochondrial toxicity]], [[smoke inhalation]] | ||
|- | |- | ||
|} | |} | ||
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*[[Asthma]] | *[[Asthma]] | ||
*[[Atenolol]] | *[[Atenolol]] | ||
*[[Beriberi heart disease]] | |||
*[[Beriberi | |||
*[[Biguanide]] | *[[Biguanide]] | ||
*[[Buformin]] | *[[Buformin]] | ||
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*[[Carbon monoxide poisoning]] | *[[Carbon monoxide poisoning]] | ||
*[[Cardiac arrest]] | *[[Cardiac arrest]] | ||
*[[Cardiac | *[[Cardiac catheterization]] | ||
*[[Cardiomyopathy ]] | *[[Cardiomyopathy ]] | ||
*[[Chronic fatigue syndrome]] | *[[Chronic fatigue syndrome]] | ||
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*[[Diabetic nephropathy]] | *[[Diabetic nephropathy]] | ||
*[[Didanosine]] | *[[Didanosine]] | ||
*[[Entecavir]] | *[[Entecavir]] | ||
*[[Ethanol]] | *[[Ethanol]] | ||
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*[[Exercise]] | *[[Exercise]] | ||
*[[Fetal distress]] | *[[Fetal distress]] | ||
*[[Fructose intolerance]] | |||
{{col-break|width=33%}} | {{col-break|width=33%}} | ||
*[[Fructose-1-phosphate aldolase deficiency]] | *[[Fructose-1-phosphate aldolase deficiency]] | ||
*[[Fructose-1,6-diphosphatase deficiency]] | *[[Fructose-1,6-diphosphatase deficiency]] | ||
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*[[Mesenteric ischemia]] | *[[Mesenteric ischemia]] | ||
*[[Metabolic syndrome]] | *[[Metabolic syndrome]] | ||
*[[Metformin]] | |||
{{col-break|width=33%}} | {{col-break|width=33%}} | ||
*[[Mitochondrial myopathy]] | *[[Mitochondrial myopathy]] | ||
*[[Mitochondrial toxicity]] | *[[Mitochondrial toxicity]] | ||
*[[Multiple organ dysfunction syndrome]] | *[[Multiple organ dysfunction syndrome]] | ||
*[[Myocardial | *[[Myocardial infarction]] | ||
*[[Non Hodgkin's lymphoma]] | *[[Non Hodgkin's lymphoma]] | ||
*[[Oligohydramnios]] | *[[Oligohydramnios]] | ||
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*[[Shock]] | *[[Shock]] | ||
*[[Short bowel syndrome]] | *[[Short bowel syndrome]] | ||
*[[Small bowel bacterial overgrowth syndrome]] | |||
*[[Smoke inhalation]] | *[[Smoke inhalation]] | ||
*[[ST | *[[ST elevation myocardial infarction complications]] | ||
*[[Stavudine]] | *[[Stavudine]] | ||
*[[Stribild]] | |||
*[[Strychnine]] | *[[Strychnine]] | ||
*[[Telbivudine]] | *[[Telbivudine]] | ||
*[[Tenofovir]] | *[[Tenofovir]] | ||
*[[ | *[[Thiamine deficiency]] | ||
*[[Tumors]] | *[[Tumors]] | ||
*[[Von Gierke | *[[Von Gierke disease]] | ||
*[[Zalcitabine]] | *[[Zalcitabine]] | ||
*[[Zidovudine]] | |||
{{col-end}} | {{col-end}} | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Crowdiagnosis]] | |||
[[Category:Electrolyte disturbance]] | [[Category:Electrolyte disturbance]] | ||
[[Category:Medical emergencies]] | [[Category:Medical emergencies]] | ||
Latest revision as of 22:41, 8 December 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Lactic acidosis is one of the most common causes of high anion gap metabolic acidosis and is usually associated with a serum lactate levels above 4 mmol/L. Reduced oxygen tension shunts glycolysis towards pyruvate production, which in turn leads to lactate accumulation since pyruvate can no longer undergo aerobic metabolism.
Causes
Life Threatening Causes
Life-threatening causes include conditions which result in death or permanent disability within 24 hours if left untreated.
Common Causes
- Alcoholism
- Carbon monoxide poisoning
- Cyanide poisoning
- Exercise
- Grand mal seizure
- Hypoglycemia
- Hypoxemia
- Malignancy
- Metformin
- Pheochromocytoma
- Pulmonary edema
- Salicylate intoxication
- Stavudine
- Zidovudine
Causes by Organ System
Causes by Organ System developed by WikiDoc.org, Copyleft 2013