Lactic acidosis causes: Difference between revisions
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==Overview== | ==Overview== | ||
Lactic acidosis is one of the most common causes of high [[anion gap]] [[metabolic acidosis]] and is usually associated with a serum [[lactate]] levels above 4 mmol/L. Reduced oxygen tension shunts [[glycolysis]] towards [[pyruvate]] production, which in turn leads to lactate accumulation since pyruvate can no longer undergo [[aerobic metabolism]]. | Lactic acidosis is one of the most common causes of high [[anion gap]] [[metabolic acidosis]] and is usually associated with a serum [[lactate]] levels above 4 mmol/L. Reduced oxygen tension shunts [[glycolysis]] towards [[pyruvate]] production, which in turn leads to lactate accumulation since pyruvate can no longer undergo [[aerobic metabolism]]. | ||
==Causes== | ==Causes== | ||
===Life Threatening Causes=== | ===Life Threatening Causes=== | ||
Life-threatening causes include conditions which result in death or permanent disability within 24 hours if left untreated. | |||
*[[Cardiac arrest]] | *[[Cardiac arrest]] | ||
*[[Mesenteric ischemia]] | *[[Mesenteric ischemia]] | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Drug Side Effect''' | | '''Drug Side Effect''' | ||
|bgcolor="Beige"| [[Abacavir]], [[adefovir]], [[atenolol]], [[biguanide]], [[buformin]], [[didanosine]], [[emtricitabine]], [[entecavir]], [[lamivudine]], [[linezolid]], [[metformin]], [[paracetamol]], [[phenformin]], | |bgcolor="Beige"| [[Abacavir]], [[adefovir]], [[atenolol]], [[biguanide]], [[buformin]], [[didanosine]], [[emtricitabine]], [[entecavir]], [[Glyburide and Metformin]], [[lamivudine]], [[Linagliptin and Metformin hydrochloride]], [[linezolid]], [[metformin]], [[paracetamol]], [[phenformin]], [[Repaglinide and Metformin hydrochloride]], [[Reye's syndrome]], [[salicylate intoxication]], [[Saxagliptin hydrochloride and Metformin hydrochloride]], [[stavudine]], [[strychnine]], [[telbivudine]], [[tenofovir]], [[zalcitabine]], [[Zidovudine]] | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Miscellaneous''' | | '''Miscellaneous''' | ||
|bgcolor="Beige"|[[Chronic fatigue syndrome]] , [[coenzyme Q10|coenzyme q10 deficiency]], [[exercise]], [[glycogen storage disease]], [[hypothermia]], [[idiopathic]], [[malignant hyperpyrexia]], [[mitochondrial toxicity]], [[smoke inhalation]] | |bgcolor="Beige"|[[Chronic fatigue syndrome]], [[coenzyme Q10|coenzyme q10 deficiency]], [[exercise]], [[glycogen storage disease]], [[hypothermia]], [[idiopathic]], [[malignant hyperpyrexia]], [[mitochondrial toxicity]], [[smoke inhalation]] | ||
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*[[Diabetic nephropathy]] | *[[Diabetic nephropathy]] | ||
*[[Didanosine]] | *[[Didanosine]] | ||
*[[Entecavir]] | *[[Entecavir]] | ||
*[[Ethanol]] | *[[Ethanol]] | ||
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*[[Small bowel bacterial overgrowth syndrome]] | *[[Small bowel bacterial overgrowth syndrome]] | ||
*[[Smoke inhalation]] | *[[Smoke inhalation]] | ||
*[[ | *[[ST elevation myocardial infarction complications]] | ||
*[[Stavudine]] | *[[Stavudine]] | ||
*[[Stribild]] | |||
*[[Strychnine]] | *[[Strychnine]] | ||
*[[Telbivudine]] | *[[Telbivudine]] | ||
*[[Tenofovir]] | *[[Tenofovir]] | ||
*[[ | *[[Thiamine deficiency]] | ||
*[[Tumors]] | *[[Tumors]] | ||
*[[Von Gierke disease]] | *[[Von Gierke disease]] | ||
*[[Zalcitabine]] | *[[Zalcitabine]] | ||
*[[Zidovudine]] | |||
{{col-end}} | {{col-end}} | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Crowdiagnosis]] | |||
[[Category:Electrolyte disturbance]] | [[Category:Electrolyte disturbance]] | ||
[[Category:Medical emergencies]] | [[Category:Medical emergencies]] | ||
Latest revision as of 22:41, 8 December 2014
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Lactic acidosis Microchapters |
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Lactic acidosis causes On the Web |
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Risk calculators and risk factors for Lactic acidosis causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Lactic acidosis is one of the most common causes of high anion gap metabolic acidosis and is usually associated with a serum lactate levels above 4 mmol/L. Reduced oxygen tension shunts glycolysis towards pyruvate production, which in turn leads to lactate accumulation since pyruvate can no longer undergo aerobic metabolism.
Causes
Life Threatening Causes
Life-threatening causes include conditions which result in death or permanent disability within 24 hours if left untreated.
Common Causes
- Alcoholism
- Carbon monoxide poisoning
- Cyanide poisoning
- Exercise
- Grand mal seizure
- Hypoglycemia
- Hypoxemia
- Malignancy
- Metformin
- Pheochromocytoma
- Pulmonary edema
- Salicylate intoxication
- Stavudine
- Zidovudine
Causes by Organ System
Causes by Organ System developed by WikiDoc.org, Copyleft 2013