Cardiomyopathy causes: Difference between revisions

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__NOTOC__
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{{Cardiomyopathy}}
{{Cardiomyopathy}}
{{CMG}}; {{AE}} {{AO}}
{{CMG}}; {{AE}} {{EdzelCo}}
 
==Overview==
==Overview==
There is a very wide range of factors that can cause cardiomyopathy, ranging from [[infectious]] causes, [[toxin]]s, [[genetic]] causes and other disease processes.
There are numerous causes of cardiomyopathies depending on the type in question.  Some of the causes include: [[genetic]] (e.g. [[hereditary spherocytosis]], [[familial cardiomyopathy]], [[Friedreich's ataxia]]); [[metabolic]] (e.g. [[beriberi]], [[Gaucher's disease]], [[uremia]]); and [[infectious]] (e.g. [[Adenoviridae|adenovirus]], [[african trypanosomiasis]], [[arbovirus]], [[ascariasis]]).  Cardiomyopathies usually have an insidious onset but life-threatening causes including [[acute coronary syndrome]], [[electrolyte imbalance]], and [[cocaine abuse]] which must be identified and managed accordingly. Other common causes include [[alcoholism]], [[diabetes mellitus]], and [[hypothyroidism]].


==Causes==
==Causes==


===Life Threatening Causes===
===Life Threatening Causes===
Life-threatening causes include conditions which result in death or permanent disability within 24 hours if left untreated.
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.<ref name="pmid24976920">{{cite journal |vauthors=Sisakian H |title=Cardiomyopathies: Evolution of pathogenesis concepts and potential for new therapies |journal=World J Cardiol |volume=6 |issue=6 |pages=478–94 |date=June 2014 |pmid=24976920 |doi=10.4330/wjc.v6.i6.478 |url=}}</ref>


*[[Acute coronary syndrome]]
*[[Acute coronary syndrome]]
*[[Beriberi]]
*[[Carbon monoxide toxicity]]
*[[Carbon monoxide toxicity]]
*[[Cocaine abuse]]
*[[Cocaine abuse]]
Line 36: Line 34:
*[[Idiopathic dilated cardiomyopathy]]  
*[[Idiopathic dilated cardiomyopathy]]  
*[[Kwashiorkor]]  
*[[Kwashiorkor]]  
*[[Peripartum cardiomyopathy]]
*[[Stress cardiomyopathy]]
*[[Tricyclic anti-depressant#Overdose|Tricyclic anti-depressant overdose]]
*[[Tricyclic anti-depressant#Overdose|Tricyclic anti-depressant overdose]]


===Causes by Organ System===
===Causes by Organ System===
{|style="width:80%; height:100px" border="1"
{| style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
| style="width:25%" bgcolor="lightsteelblue" ; border="1" | '''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" |  
| style="width:75%" bgcolor="beige" ; border="1" | [[Arrhythmogenic right ventricular dysplasia]], [[Idiopathic Infantile Arterial Calcification|arterial calcification of infancy]], [[Brugada syndrome]], [[Transplant rejection|cardiac transplant rejection]], cardiomyopathy-renal anomalies,<ref name="Leask-2007">{{Cite journal  | last1 = Leask | first1 = KM. | last2 = Kerr | first2 = B. | last3 = Ladusans | first3 = E. | title = Cardiomyopathy with renal anomalies in two siblings: a new recessive syndrome? | journal = Clin Dysmorphol | volume = 16 | issue = 1 | pages = 51-3 | month = Jan | year = 2007 | doi = 10.1097/MCD.0b013e328010caa9 | PMID = 17159516 }}</ref> [[chronic tachycardia]], [[coronary artery disease]], [[Cytochrome c oxidase|cytochrome C oxidase deficiency]], [[endomyocardial fibrosis]], [[eosinophilic endomyocardial disease]], [[giant cell myocarditis]], [[hypertension]], [[Keshan disease]] , [[left ventricular noncompaction]], [[Loeffler endocarditis]], [[myocarditis]], [[Naxos disease]], obesity-colitis-hypothyroidism-cardiac hypertrophy-developmental delay,<ref name="Tan-2007">{{Cite journal  | last1 = Tan | first1 = TY. | last2 = Amor | first2 = DJ. | title = Obesity, hypothyroidism, craniosynostosis, cardiac hypertrophy, colitis, and developmental delay: a novel syndrome. | journal = Am J Med Genet A | volume = 143 | issue = 2 | pages = 114-8 | month = Jan | year = 2007 | doi = 10.1002/ajmg.a.31548 | PMID = 17163533 }}</ref> [[prolonged QT syndrome]], X-linked dilated cardiomyopathy,<ref name="Towbin-1993">{{Cite journal  | last1 = Towbin |first1 = JA. | last2 = Hejtmancik | first2 = JF. | last3 = Brink | first3 = P. | last4 = Gelb | first4 = B. | last5 = Zhu | first5 = XM. | last6 = Chamberlain | first6 = JS. | last7 = McCabe | first7 = ER. | last8 = Swift | first8 = M. | title = X-linked dilated cardiomyopathy. Molecular genetic evidence of linkage to the Duchenne muscular dystrophy (dystrophin) gene at the Xp21 locus. | journal = Circulation | volume = 87 | issue = 6 | pages = 1854-65 | month = Jun | year = 1993 | doi =  | PMID = 8504498 }}</ref> X-linked fatal infantile cardiomyopathy<ref name="Gedeon-1995">{{Cite journal  | last1 = Gedeon | first1 = AK. | last2 = Wilson | first2 = MJ. | last3 = Colley | first3 = AC. | last4 = Sillence | first4 = DO. | last5 = Mulley | first5 = JC. | title = X linked fatal infantile cardiomyopathy maps to Xq28 and is possibly allelic to Barth syndrome. | journal = J Med Genet | volume = 32 | issue = 5 | pages = 383-8 | month = May | year = 1995 | doi =  | PMID = 7616547 }}</ref>
[[Arrhythmogenic right ventricular dysplasia]],  
[[Idiopathic Infantile Arterial Calcification|arterial calcification of infancy]],  
[[Brugada syndrome]], [[Transplant rejection|cardiac transplant rejection]],
cardiomyopathy-renal anomalies<ref name="Leask-2007">{{Cite journal  | last1 = Leask | first1 = KM. | last2 = Kerr | first2 = B. | last3 = Ladusans | first3 = E. | title = Cardiomyopathy with renal anomalies in two siblings: a new recessive syndrome? | journal = Clin Dysmorphol | volume = 16 | issue = 1 | pages = 51-3 | month = Jan | year = 2007 | doi = 10.1097/MCD.0b013e328010caa9 | PMID = 17159516 }}</ref>,
[[chronic tachycardia]],  
[[coronary artery disease]],
[[Cytochrome c oxidase|cytochrome c oxidase deficiency]],
[[endomyocardial fibrosis]],  
[[eosinophilic endomyocardial disease]],  
[[giant cell myocarditis]],  
[[hypertension]],  
[[Keshan disease]],  
[[left ventricular noncompaction]],  
[[Loeffler endocarditis]],  
[[myocarditis]],  
[[Naxos disease]],  
obesity-colitis-hypothyroidism-cardiac hypertrophy-developmental delay<ref name="Tan-2007">{{Cite journal  | last1 = Tan | first1 = TY. | last2 = Amor | first2 = DJ. | title = Obesity, hypothyroidism, craniosynostosis, cardiac hypertrophy, colitis, and developmental delay: a novel syndrome. | journal = Am J Med Genet A | volume = 143 | issue = 2 | pages = 114-8 | month = Jan | year = 2007 | doi = 10.1002/ajmg.a.31548 | PMID = 17163533 }}</ref>,
[[prolonged QT syndrome]],  
X-linked dilated cardiomyopathy<ref name="Towbin-1993">{{Cite journal  | last1 = Towbin | first1 = JA. | last2 = Hejtmancik | first2 = JF. | last3 = Brink | first3 = P. | last4 = Gelb | first4 = B. | last5 = Zhu | first5 = XM. | last6 = Chamberlain | first6 = JS. | last7 = McCabe | first7 = ER. | last8 = Swift | first8 = M. | title = X-linked dilated cardiomyopathy. Molecular genetic evidence of linkage to the Duchenne muscular dystrophy (dystrophin) gene at the Xp21 locus. | journal = Circulation | volume = 87 | issue = 6 | pages = 1854-65 | month = Jun | year = 1993 | doi =  | PMID = 8504498 }}</ref>, X-linked fatal infantile cardiomyopathy<ref name="Gedeon-1995">{{Cite journal  | last1 = Gedeon | first1 = AK. | last2 = Wilson | first2 = MJ. | last3 = Colley | first3 = AC. | last4 = Sillence | first4 = DO. | last5 = Mulley | first5 = JC. | title = X linked fatal infantile cardiomyopathy maps to Xq28 and is possibly allelic to Barth syndrome. | journal = J Med Genet | volume = 32 | issue = 5 | pages = 383-8 | month = May | year = 1995 | doi =  | PMID = 7616547 }}</ref>
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Chemical / poisoning'''
| '''Chemical / poisoning'''
| bgcolor="beige" | [[Arsenic]], [[cobalt]], [[Herbicide|endothall]], [[ethanol]], [[lead]], [[thallium]], [[allylamine]], [[carbon monoxide]], [[toxic mushrooms]]
|bgcolor="Beige"|  
[[Arsenic]],  
[[cobalt]],  
[[Herbicide|endothall]],  
[[ethanol]],  
[[lead]],  
[[thallium]],
<font color="#777777">[[allylamine]],</font>
<font color="#777777">[[carbon monoxide]],</font>
<font color="#777777">[[toxic mushrooms]]</font>
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Dermatologic'''
| '''Dermatologic'''
| bgcolor="beige" | Familial cutaneous collagenoma,<ref name="Dawn-">{{Cite journal  | last1 = Dawn | first1 = ME. | last2 = Deng | first2 = AC. | last3 = Petrali | first3 = J. | last4 = Wessely | first4 = C. | last5 = Jaffe | first5 = D. | last6 = Gaspari | first6 = AA. | title = Familial cutaneous collagenoma. | journal = Skinmed | volume = 7 | issue = 1 | pages = 43-5 | month =  | year =  | doi =  | PMID = 18174804 }}</ref> [[lentiginosis]], [[dermatomyositis]], [[Carvajal-Huerta syndrome]], [[Histiocytosis|Hand-Schuller-Christian syndrome]], [[McLeod syndrome]], [[multiple lentigines syndrome]], [[Naxos disease]], [[pityriasis lichenoides et varioliformis acuta]], [[Refsum disease]]
|bgcolor="Beige"|  
Familial cutaneous collagenoma<ref name="Dawn-">{{Cite journal  | last1 = Dawn | first1 = ME. | last2 = Deng | first2 = AC. | last3 = Petrali | first3 = J. | last4 = Wessely | first4 = C. | last5 = Jaffe | first5 = D. | last6 = Gaspari | first6 = AA. | title = Familial cutaneous collagenoma. | journal = Skinmed | volume = 7 | issue = 1 | pages = 43-5 | month =  | year =  | doi =  | PMID = 18174804 }}</ref>,
[[lentiginosis]],  
[[dermatomyositis]],  
[[Carvajal-Huerta syndrome]],
[[Histiocytosis|Hand-Schuller-Christian syndrome]],  
[[McLeod syndrome]],  
[[multiple lentigines syndrome]],  
[[Naxos disease]],  
pityriasis lichenoides et varioliformis acuta (PLEVA),  
[[Refsum disease]]
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Drug Side Effect'''
| '''Drug Side Effect'''
| bgcolor="beige" | [[5-fluorouracil]], [[Anthracycline|aclarubicin]], [[actinomycin D]], [[alemtuzumab]], [[Anthracycline|amrubicin]], [[bleomycin]], [[Benzphetamine]], [[capecitabine]], [[certolizumab pegol]], [[Cidofovir]], [[cisplatin]], [[clozapine]], [[cyclophosphamide]], [[Cytarabine]], [[dasatinib]], [[daunorubicin]], [[Dextroamphetamine]], [[disopyramide]], [[Doxorubicin Hydrochloride]], [[epirubicin]], [[fenfluramine]], [[hydralazine]], [[hydroxychloroquine]], [[idarubicin]], [[imatinib]], [[interferon-alpha]], [[Interferon alfa-2b ]] , [[Ixabepilone]], [[Megestrol]], [[mitoxantrone]], [[paclitaxel]],   [[paracetamol]], [[Pegylated interferon alfa-2b]], [[Anthracyclines|pirarubicin]], [[pixantrone]], [[streptomycin]], [[sunitinib]], [[tacrolimus]], [[Trametinib]],  [[trastuzumab]], [[Tricyclic antidepressant#Overdose|tricyclic anti-depressant abuse]], [[Valdecoxib]], [[valrubicin]]
|bgcolor="Beige"|
[[5-fluorouracil]],  
[[Anthracycline|aclarubicin]],
[[actinomycin D]],  
[[alemtuzumab]],  
[[Anthracycline|amrubicin]],  
[[bleomycin]],
[[certolizumab pegol]],  
[[cisplatin]],  
[[clozapine]],  
[[cyclophosphamide]],
[[dasatinib]],  
[[daunorubicin]],  
[[disopyramide]],  
[[doxorubicin]],  
[[epirubicin]],  
[[fenfluramine]],  
[[hydralazine]],  
[[idarubicin]],
[[imatinib]],  
[[interferon-alpha]],  
[[mitoxantrone]],  
[[paclitaxel]],
[[paracetamol]],
[[Anthracyclines|pirarubicin]],  
[[pixantrone]],  
[[streptomycin]],  
[[sunitinib]],  
[[tacrolimus]],  
[[trastuzumab]],  
[[Tricyclic antidepressant#Overdose|tricyclic anti-depressant abuse]],
[[valrubicin]]  
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Ear Nose Throat'''
| '''Ear Nose Throat'''
| bgcolor="beige" | No underlying causes
|bgcolor="Beige"| No underlying causes
|-  
|-  
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Endocrine'''
| '''Endocrine'''
| bgcolor="beige" | [[Acromegaly]], [[amyloidosis]], [[carcinoid syndrome]], [[celiac disease]], [[cushing syndrome]], [[diabetes mellitus]], [[gout]], [[hemochromatosis]], [[hyperparathyroidism]], [[hyperthyroidism]], [[hypothyroidism]], obesity-colitis-hypothyroidism-cardiac hypertrophy developmental delay,<ref name="Tan-2007">{{Cite journal  | last1 = Tan | first1 = TY. | last2 = Amor | first2 = DJ. | title = Obesity, hypothyroidism, craniosynostosis, cardiac hypertrophy, colitis, and developmental delay: a novel syndrome. | journal = Am J Med Genet A | volume = 143 | issue = 2 | pages = 114-8 | month = Jan | year = 2007 | doi = 10.1002/ajmg.a.31548 | PMID = 17163533 }}</ref> [[paraneoplastic syndromes]], [[pheochromocytoma]], [[pituitary tumor]], [[WAGR syndrome]], [[Whipple's disease]]  
|bgcolor="Beige"|  
[[Acromegaly]],  
[[amyloidosis]],  
[[carcinoid syndrome]],    
[[celiac disease]],  
[[cushing syndrome]],  
[[diabetes Mellitus]],  
[[gout]],  
[[hemochromatosis]],  
[[hyperparathyroidism]],
[[hyperthyroidism]],  
[[hypothyroidism]],  
obesity-colitis-hypothyroidism-cardiac hypertrophy developmental delay<ref name="Tan-2007">{{Cite journal  | last1 = Tan | first1 = TY. | last2 = Amor | first2 = DJ. | title = Obesity, hypothyroidism, craniosynostosis, cardiac hypertrophy, colitis, and developmental delay: a novel syndrome. | journal = Am J Med Genet A | volume = 143 | issue = 2 | pages = 114-8 | month = Jan | year = 2007 | doi = 10.1002/ajmg.a.31548 | PMID = 17163533 }}</ref>,
[[paraneoplastic syndromes]],  
[[pheochromocytoma]],
[[pituitary tumor]],  
[[WAGR syndrome]],  
[[Whipple's disease]]  
|-  
|-  
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Environmental'''
| '''Environmental'''
| bgcolor="beige" |  [[Heatstroke]], [[hypothermia]], [[Electrical injury#Cardiac Injury|lightning strike]], [[radiation]]
|bgcolor="Beige"|  [[Heatstroke]], [[hypothermia]], [[Electrical injury#Cardiac Injury|lightning strike]], [[radiation]]
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Gastroenterologic'''
| '''Gastroenterologic'''
| bgcolor="beige" |  [[Hemochromatosis]], obesity-colitis-hypothyroidism-cardiac hypertrophy-developmental delay complex, <ref name="Tan-2007">{{Cite journal  | last1 = Tan | first1 = TY. | last2 = Amor | first2 = DJ. | title = Obesity, hypothyroidism, craniosynostosis, cardiac hypertrophy, colitis, and developmental delay: a novel syndrome. | journal = Am J Med Genet A | volume = 143 | issue = 2 | pages = 114-8 | month = Jan | year = 2007 | doi = 10.1002/ajmg.a.31548 | PMID = 17163533 }}</ref>[[Whipple's disease]]
|bgcolor="Beige"|  [[Hemochromatosis]], obesity-colitis-hypothyroidism-cardiac hypertrophy-developmental delay complex<ref name="Tan-2007">{{Cite journal  | last1 = Tan | first1 = TY. | last2 = Amor | first2 = DJ. | title = Obesity, hypothyroidism, craniosynostosis, cardiac hypertrophy, colitis, and developmental delay: a novel syndrome. | journal = Am J Med Genet A | volume = 143 | issue = 2 | pages = 114-8 | month = Jan | year = 2007 | doi = 10.1002/ajmg.a.31548 | PMID = 17163533 }}</ref>, [[Whipple's Disease]]
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Genetic'''
| '''Genetic'''
| bgcolor="beige" | [[Alpers' disease]], [[Aspartylglucosaminuria|Borud syndrome]], [[Brugada syndrome]], [[Carvajal-Huerta syndrome]], [[congenital disorders of glycosylation]], [[congenital generalized lipodystrophy]], [[Costello syndrome]], [[Cytochrome c oxidase|cytochrome C oxidase deficiency]], [[desmin-related myofibrillar myopathy]], [[Emery-Dreifuss muscular dystrophy]], [[familial cardiomyopathy]], [[Friedreich's ataxia]], [[hereditary spherocytosis]], [[Hurler syndrome]], [[Hutchinson-Gilford progeria syndrome]], [[Cantu syndrome|hypertrichotic osteochondrodysplasia]], [[Keshan disease]], [[Laing distal myopathy]], [[Congenital muscular dystrophy|LAMA2-related muscular dystrophy]], [[mitochondrial trifunctional protein deficiency]], [[multiple lentigines syndrome]], [[muscular dystrophy]], [[Naxos disease]], [[Noonan syndrome]], [[porphyria]], [[prolonged QT syndrome]], [[pseudoxanthoma elasticum]], [[Refsum disease]], [[NADH dehydrogenase|respiratory chain complex I deficiency]], [[Salih myopathy]], [[SGCG|sarcoglycanopathy]], [[Oculofaciocardiodental syndrome|syndromic microphthalmia type 7]], [[WAGR syndrome]], X-linked dilated cardiomyopathy, <ref name="Towbin-1993">{{Cite journal  | last1 = Towbin | first1 = JA. | last2 = Hejtmancik | first2 = JF. | last3 = Brink | first3 = P. | last4 = Gelb | first4 = B. | last5 = Zhu | first5 = XM. | last6 = Chamberlain | first6 = JS. | last7 = McCabe | first7 = ER. | last8 = Swift | first8 = M. | title = X-linked dilated cardiomyopathy. Molecular genetic evidence of linkage to the Duchenne muscular dystrophy (dystrophin) gene at the Xp21 locus. | journal = Circulation | volume = 87 | issue = 6 | pages = 1854-65 | month = Jun | year = 1993 | doi =  | PMID = 8504498 }}</ref> X-linked fatal infantile cardiomyopathy, <ref name="Gedeon-1995">{{Cite journal  | last1 = Gedeon | first1 = AK. | last2 = Wilson | first2 = MJ. | last3 = Colley | first3 = AC. | last4 = Sillence | first4 = DO. | last5 = Mulley | first5 = JC. | title = X linked fatal infantile cardiomyopathy maps to Xq28 and is possibly allelic to Barth syndrome. | journal = J Med Genet | volume = 32 | issue = 5 | pages = 383-8 | month = May | year = 1995 | doi =  | PMID = 7616547 }}</ref> [[Yunis-Varon syndrome]]  
|bgcolor="Beige"|  
[[Alpers' disease]],  
[[Brugada syndrome]],
[[Carvajal-Huerta syndrome]],  
chromosome 11, partial deletion,
[[congenital disorders of glycosylation]],  
[[congenital generalized lipodystrophy]],  
[[Costello syndrome]],
[[Cytochrome c oxidase|cytochrome c oxidase deficiency]]
[[Desmin-related myofibrillar myopathy]],  
[[Emery-Dreifuss muscular dystrophy]],  
[[familial cardiomyopathy]],  
[[Friedreich's ataxia]],  
[[hereditary spherocytosis]],  
[[Hurler syndrome]],  
[[Hutchinson-Gilford progeria syndrome]],
[[Cantu syndrome|hypertrichotic osteochondrodysplasia]],  
[[Keshan disease]],  
[[Laing distal myopathy]],  
[[Congenital muscular dystrophy|LAMA2-related muscular dystrophy]],
[[mitochondrial trifunctional protein deficiency]],  
[[multiple lentigines syndrome]],  
[[muscular dystrophy]],  
[[Naxos disease]],  
[[Noonan syndrome]],
[[porphyria]],  
[[prolonged QT syndrome]],  
[[pseudoxanthoma elasticum]],  
[[Refsum disease]],  
[[Salih myopathy]],  
sarcoglycanopathy,
[[Oculofaciocardiodental syndrome|syndromic microphthalmia type 7]],  
[[WAGR syndrome]],
X-linked dilated cardiomyopathy<ref name="Towbin-1993">{{Cite journal  | last1 = Towbin | first1 = JA. | last2 = Hejtmancik | first2 = JF. | last3 = Brink | first3 = P. | last4 = Gelb | first4 = B. | last5 = Zhu | first5 = XM. | last6 = Chamberlain | first6 = JS. | last7 = McCabe | first7 = ER. | last8 = Swift | first8 = M. | title = X-linked dilated cardiomyopathy. Molecular genetic evidence of linkage to the Duchenne muscular dystrophy (dystrophin) gene at the Xp21 locus. | journal = Circulation | volume = 87 | issue = 6 | pages = 1854-65 | month = Jun | year = 1993 | doi =  | PMID = 8504498 }}</ref>,
X-linked fatal infantile cardiomyopathy<ref name="Gedeon-1995">{{Cite journal  | last1 = Gedeon | first1 = AK. | last2 = Wilson | first2 = MJ. | last3 = Colley | first3 = AC. | last4 = Sillence | first4 = DO. | last5 = Mulley | first5 = JC. | title = X linked fatal infantile cardiomyopathy maps to Xq28 and is possibly allelic to Barth syndrome. | journal = J Med Genet | volume = 32 | issue = 5 | pages = 383-8 | month = May | year = 1995 | doi =  | PMID = 7616547 }}</ref>, [[Yunis-Varon syndrome]]  
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Hematologic'''
| '''Hematologic'''
| bgcolor="beige" | [[Hereditary spherocytosis]]
|bgcolor="Beige"| [[Hereditary spherocytosis]]
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Iatrogenic'''
| '''Iatrogenic'''
| bgcolor="beige" | [[Radiation therapy|Cardiac irradiation]]
|bgcolor="Beige"| [[Radiation therapy|Cardiac irradiation]]
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Infectious Disease'''
| '''Infectious Disease'''
| bgcolor="beige" | [[Adenovirus]], [[african trypanosomiasis]], [[arbovirus]], [[ascariasis]], [[aspergillosis]], [[beta-hemolytic streptococci]], [[blastomycosis]], [[brucella]], [[Chagas disease]], [[coccidioidomycosis]], [[coxsackie A virus]], [[Coxsackie B|coxsackie virus B1-B5]], [[cryptococcosis]], [[cysticercosis]], [[cytomegalovirus]], [[diptheria]], [[echovirus]], [[enterococci]], [[Epstein-Barr virus]] ([[EBV]]), [[filariasis]], [[flavivirus]], [[histoplasmosis]], [[HIV]], [[influenza]], [[leishmaniasis]], [[leptospirosis]], [[loeffler endocarditis]], [[Lyme disease]], [[malaria]], [[measles]], [[mumps]], [[pertussis]], [[poliomyelitis]], [[psittacosis]], [[Q fever]], [[rabies]], [[rheumatic fever]], [[rocky mountain spotted fever]], [[Sarcocystis|sarcosporidiosis]], [[schistosomiasis]], [[staphylococcus]], [[syphilis]], [[tetanus]], [[toxoplasmosis]], [[trichinosis]], [[tuberculosis]], [[typhoid fever]], [[varicella-zoster virus]]
|bgcolor="Beige"|  
 
[[Adenovirus]],  
[[African trypanosomiasis]],  
[[arbovirus]],  
[[ascariasis]],  
[[Aspergillosis]],  
[[Beta-hemolytic streptococci]],  
[[blastomycosis]],  
[[brucella]],  
[[Chagas disease]],  
[[coccidioidomycosis]],  
[[coxsackie A virus]],  
[[Coxsackie B|coxsackie virus B1-B5]],  
[[cryptococcosis]],  
[[cysticercosis]],  
[[cytomegalovirus]],  
[[diptheria]],  
[[echovirus]],  
[[enterococci]],
[[Epstein-Barr virus]] ([[EBV]]),  
[[filariasis]],  
[[flavivirus]],  
[[histoplasmosis]],
[[HIV]],  
[[influenza]],  
[[leishmaniasis]],  
[[leptospirosis]],  
[[loeffler endocarditis]],  
[[Lyme disease]],  
[[malaria]],  
[[measles]],  
[[mumps]],  
[[pertussis]],  
[[poliomyelitis]],  
[[psittacosis]],  
[[Q fever]],  
[[rabies]],  
[[rheumatic fever]],
[[rocky mountain spotted fever]],  
sarcosporidiosis,  
[[schistosomiasis]],  
[[staphylococcus]],  
[[syphilis]],  
[[tetanus]],  
[[toxoplasmosis]],  
[[trichinosis]],
[[tuberculosis]],  
[[typhoid fever]],  
[[varicella-zoster virus]]
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Musculoskeletal / Ortho'''
| '''Musculoskeletal / Ortho'''
| bgcolor="beige" | [[Arthrogryposis due to muscular dystrophy]], [[Cytochrome c oxidase|cytochrome c oxidase deficiency]], [[dermatomyositis]], [[Duchenne muscular dystrophy]], [[Emery-Dreifuss muscular dystrophy]], [[Histiocytosis|Hand-Schuller-Christian Syndrome]], [[Kearns-Sayre syndrome]],  [[mitochondrial myopathy]], [[muscular dystrophy]], [[myotonic dystrophy]]
|bgcolor="Beige"|  
[[Arthrogryposis due to muscular dystrophy]],  
[[Cytochrome c oxidase|cytochrome c oxidase deficiency]],  
[[dermatomyositis]],  
[[duchenne muscular dystrophy]],  
[[Emery-Dreifuss muscular dystrophy]],  
[[Histiocytosis|Hand-Schuller-Christian Syndrome]],
[[Kearns-Sayre syndrome]],   
[[mitochondrial myopathy]],  
[[muscular dystrophy]],  
[[myotonic dystrophy]]
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Neurologic'''
| '''Neurologic'''
| bgcolor="beige" | [[Alpers' disease]], [[D2HGDH|d-2-hydroxyglutarate dehydrogenase deficiency]], [[Friedreich's ataxia]], [[Histiocytosis|Hand-Schuller-Christian Syndrome]], [[Kearns-Sayre syndrome]], [[MELAS syndrome]], [[Whipple's disease]]  
|bgcolor="Beige"|  
[[Alpers' disease]],
[[D2HGDH|d-2-hydroxyglutarate dehydrogenase deficiency]],
[[Friedreich's ataxia]],  
[[Histiocytosis|Hand-Schuller-Christian Syndrome]],  
[[Kearns-Sayre syndrome]],  
[[MELAS syndrome]]
[[Whipple's disease]]  
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Nutritional / Metabolic'''
| '''Nutritional / Metabolic'''
| bgcolor="beige" | [[Barth syndrome|3-hydroxyacyl-CoA dehydrogenase deficiency]], [[beriberi]], [[Aspartylglucosaminuria|Borud syndrome]], [[carbohydrate deficient glycoprotein syndrome type 1a]], [[carnitine deficiency]], [[Coenzyme Q10#Cardiac and Vascular Disease|Coenzyme Q10 (CoQ10) deficiency]], [[coenzyme Q cytochrome c reductase deficiency]], [[congenital disorder of glycosylation]], [[cytochrome C Oxidase deficiency]], [[D2HGDH|d-2-hydroxyglutarate dehydrogenase deficiency]], [[Fabry disease]], [[gangliosidosis]], [[Gaucher's disease]], [[glutaric acidemia type 2]], [[gout]], [[hemochromatosis]], [[Hunter syndrome]], [[Hurler syndrome]], [[isobutyryl-coenzyme A dehydrogenase deficiency]], [[Keshan disease]], [[kwashiorkor]], [[Long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency|long-chain Acyl CoA dehydrogenase deficiency]], [[malonic aciduria]], [[MELAS syndrome]], [[mitochondrial trifunctional protein deficiency]], [[mucopolysaccharidoses]], [[Niemann-Pick disease]], [[niacin deficiency]], [[oxalosis]], [[paraneoplastic syndromes]], [[Glycogen storage disease type II|Pompe disease]], [[porphyria]], [[Refsum disease]], [[NADH dehydrogenase|respiratory chain complex I deficiency]], [[Adenosylhomocysteinase|s-adenosylhomocysteine hydrolase deficiency]], [[scurvy]], [[selenium deficiency]], [[Leigh's disease|subacute necrotising encephalomyelopathy]], [[triosephosphate isomerase deficiency]], [[uremia]], [[vitamin B deficiency]], [[Hypervitaminosis D|vitamin D overdose]]   
|bgcolor="Beige"|  
[[Barth syndrome|3-hydroxyacyl-CoA dehydrogenase deficiency]],  
[[beriberi]] ,  
[[carbohydrate deficient glycoprotein syndrome type 1a]],  
[[carnitine deficiency]],  
[[Coenzyme Q10#Cardiac and Vascular Disease|Coenzyme Q10 (CoQ10) deficiency]],  
[[coenzyme Q cytochrome c reductase deficiency]],  
[[congenital disorder of glycosylation]],  
[[cytochrome C Oxidase deficiency]],  
[[D2HGDH|d-2-hydroxyglutarate dehydrogenase deficiency]],  
[[Fabry disease]],  
[[gangliosidosis]],  
[[Gaucher's disease]],  
[[glutaric acidemia type 2]],
[[gout]],  
[[hemochromatosis]],
[[Hunter syndrome]],  
[[Hurler syndrome]],
[[Isobutyryl-coenzyme A dehydrogenase deficiency]],  
[[Keshan disease]],
[[kwashiorkor]],  
[[Long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency|long-chain Acyl CoA dehydrogenase deficiency]],  
[[malonic aciduria]],
[[MELAS syndrome]],  
[[mitochondrial trifunctional protein deficiency]],  
[[mucopolysaccharidoses]],  
[[Niemann-Pick disease]],  
[[niacin deficiency]],  
[[oxalosis]],  
[[paraneoplastic syndromes]],  
[[Glycogen storage disease type II|Pompe disease]],  
[[porphyria]],  
[[Refsum disease]],  
respiratory chain complex I deficiency,  
[[s-adenosylhomocysteine hydrolase]] deficiency,  
[[scurvy]],  
[[selenium deficiency]],  
[[Leigh's disease|Subacute necrotising encephalomyelopathy]],  
[[triosephosphate isomerase deficiency]],  
[[Uremia]],  
[[vitamin B deficiency]],  
[[Hypervitaminosis D|vitamin D overdose]]   
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Obstetric/Gynecologic'''
| '''Obstetric/Gynecologic'''
| bgcolor="beige" | [[Peripartum cardiomyopathy]]
|bgcolor="Beige"| [[Peripartum cardiomyopathy]]
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Oncologic'''
| '''Oncologic'''
| bgcolor="beige" | [[Angioma]], [[myxomas]], [[pituitary tumour]], [[rhabdomyoma]], [[sarcoma]], [[leukemia]], [[WAGR syndrome]], [[carcinoid syndrome]]
|bgcolor="Beige"|  
[[Angioma]],  
[[myxomas]],  
[[pituitary tumour]],  
[[rhabdomyoma]],  
[[sarcoma]],  
[[leukemia]],  
[[WAGR syndrome]],  
[[carcinoid syndrome]]
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Ophthalmologic'''
| '''Opthalmologic'''
| bgcolor="beige" | [[Histiocytosis|Hand-Schuller-Christian syndrome]], [[Oculofaciocardiodental syndrome|syndromic microphthalmia type 7]], [[myotonic dystrophy]], [[WAGR syndrome]]
|bgcolor="Beige"|  
[[Histiocytosis|Hand-Schuller-Christian syndrome]],  
[[Oculofaciocardiodental syndrome|Syndromic microphthalmia type 7]],  
[[myotonic dystrophy]],  
[[WAGR syndrome]]
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Overdose / Toxicity'''
| '''Overdose / Toxicity'''
| bgcolor="beige" | [[Alcohol]], [[Cobalt#Precautions|cobalt poisoning]], [[cocaine abuse]], [[oxalosis]], [[paracetamol]], [[tricyclic antidepressant]], [[Hypervitaminosis D|vitamin D overdose]]
|bgcolor="Beige"|
[[Alcohol]],  
[[Cobalt#Precautions|cobalt poisoning]],  
[[cocaine abuse]],  
[[oxalosis]],  
[[paracetamol]],  
[[tricyclic antidepressant]],  
[[Hypervitaminosis D|vitamin D overdose]]
|-bgcolor="LightSteelBlue"
| '''Psychiatric'''
|bgcolor="Beige"| [[Takotsubo cardiomyopathy]]
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Psychiatric'''
| '''Pulmonary'''
| bgcolor="beige" | [[Takotsubo cardiomyopathy]]
|bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Pulmonary'''
| '''Renal / Electrolyte'''
| bgcolor="beige" | No underlying causes
|bgcolor="Beige"|
Cardiomyopathy-renal anomalies<ref name="Leask-2007">{{Cite journal  | last1 = Leask | first1 = KM. | last2 = Kerr | first2 = B. | last3 = Ladusans | first3 = E. | title = Cardiomyopathy with renal anomalies in two siblings: a new recessive syndrome? | journal = Clin Dysmorphol |volume = 16 | issue = 1 | pages = 51-3 | month = Jan | year = 2007 | doi = 10.1097/MCD.0b013e328010caa9 | PMID = 17159516 }}</ref>,
[[hypocalcemia]],
[[hypokalemia]],
[[hypomagnesemia]],
[[uremia]],
[[WAGR syndrome]],
[[MELAS syndrome]]
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Renal / Electrolyte'''
| '''Rheum / Immune / Allergy'''
| bgcolor="beige" | Cardiomyopathy-renal anomalies,<ref name="Leask-2007">{{Cite journal  | last1 = Leask | first1 = KM. | last2 = Kerr | first2 = B. | last3 = Ladusans | first3 = E. | title = Cardiomyopathy with renal anomalies in two siblings: a new recessive syndrome? | journal = Clin Dysmorphol |volume = 16 | issue = 1 | pages = 51-3 | month = Jan | year = 2007 | doi = 10.1097/MCD.0b013e328010caa9 | PMID = 17159516 }}</ref> [[hypocalcemia]], [[hypokalemia]], [[hypomagnesemia]], [[uremia]], [[WAGR syndrome]], [[MELAS syndrome]]
|bgcolor="Beige"|  
[[Gout]],
[[Kawasaki disease]],  
[[polyarteritis nodosa]],  
[[rheumatoid arthritis]],  
[[systemic sclerosis]],  
[[scleroderma]],  
[[systemic lupus erythematosus]]  
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Rheum / Immune / Allergy'''
| '''Sexual'''
| bgcolor="beige" | [[Gout]], [[Kawasaki disease]], [[polyarteritis nodosa]], [[rheumatoid arthritis]], [[systemic sclerosis]], [[scleroderma]], [[systemic lupus erythematosus]]
|bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Sexual'''
| '''Trauma'''
| bgcolor="beige" | No underlying causes
|bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Trauma'''
| '''Urologic'''
| bgcolor="beige" | No underlying causes
|bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Urologic'''
| '''Dental'''
| bgcolor="beige" | No underlying causes
|bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
| bgcolor="lightsteelblue" | '''Dental'''
| '''Miscellaneous'''
| bgcolor="beige" | No underlying causes
|bgcolor="Beige"|  
[[Envenomation|Black widow spider bite]],
[[Transplant rejection|cardiac transplant rejection]], 
[[idiopathic dilated cardiomyopathy]], 
[[mitochondrial trifunctional protein deficiency]],
[[obesity]],
[[obstructive sleep apnea]],
[[takotsubo cardiomyopathy|stress-induced cardiomyopathy]]
|-
|-
| bgcolor="lightsteelblue" | '''Miscellaneous'''
| bgcolor="beige" | [[Envenomation|Black widow spider bite]], [[Transplant rejection|cardiac transplant rejection]], [[idiopathic dilated cardiomyopathy]],  [[mitochondrial trifunctional protein deficiency]], [[obesity]], [[obstructive sleep apnea]], [[takotsubo cardiomyopathy|stress-induced cardiomyopathy]]
|}
|}


Line 442: Line 144:
*[[Arrhythmogenic right ventricular cardiomyopathy]]
*[[Arrhythmogenic right ventricular cardiomyopathy]]
*[[Arsenic]]
*[[Arsenic]]
*[[Idiopathic Infantile Arterial Calcification|arterial calcification of infancy]]
*[[Idiopathic Infantile Arterial Calcification|Arterial calcification of infancy]]
*[[Stickler syndrome|Arthritis-short stature-deafness syndrome]]
*[[Stickler syndrome|Arthritis-short stature-deafness syndrome]]
*[[Arthrogryposis due to muscular dystrophy]]
*[[Arthrogryposis due to muscular dystrophy]]
Line 449: Line 151:
*[[Aspergillosis]]
*[[Aspergillosis]]
*[[Progressive external ophthalmoplegia|Autosomal recessive progressive external ophthalmoplegia]]
*[[Progressive external ophthalmoplegia|Autosomal recessive progressive external ophthalmoplegia]]
*[[Barth syndrome|3-hydroxyacyl-CoA dehydrogenase deficiency]]
*[[Beriberi]]
*[[Beriberi]]
*[[Beta-hemolytic streptococci]]
*[[Beta-hemolytic streptococci]]
Line 456: Line 157:
*[[Bleomycin]]
*[[Bleomycin]]
*[[Lyme disease|Borrelia burgdorferi]]
*[[Lyme disease|Borrelia burgdorferi]]
*Borud syndrome
*[[Aspartylglucosaminuria|Borud syndrome]]
*[[Brucella]]
*[[Brucella]]
*[[Brugada syndrome]]
*[[Brugada syndrome]]
Line 472: Line 173:
*[[Chagas disease]]
*[[Chagas disease]]
*[[Chorea acanthocytosis]]
*[[Chorea acanthocytosis]]
*Chromosome 11, partial deletion
*[[Chronic tachycardia]]
*[[Chronic tachycardia]]
*[[Cidofovir]]
*[[Cisplatin]]
*[[Cisplatin]]
*[[Clozapine]]
*[[Clozapine]]
Line 491: Line 192:
*[[Cyclophosphamide]]
*[[Cyclophosphamide]]
*[[Cysticercosis]]
*[[Cysticercosis]]
*[[Cytarabine]]
*[[Cytochrome c oxidase deficiency]]
*[[Cytochrome c oxidase deficiency]]
*[[Cytomegalovirus]]
*[[Cytomegalovirus]]
Line 499: Line 201:
*[[Desmin-related myofibrillar myopathy]]
*[[Desmin-related myofibrillar myopathy]]
*[[Diabetes mellitus]]
*[[Diabetes mellitus]]
{{col-break|width=33%}}
*[[Diptheria]]
*[[Diptheria]]
*[[Disopyramide]]
*[[Disopyramide]]
*[[Doxorubicin]]
*[[Doxorubicin Hydrochloride]]
*[[Echovirus]]
*[[Echovirus]]
{{col-break|width=33%}}
*[[Electrical injury]]
*[[Electrical injury]]
*[[Emery-Dreifuss muscular dystrophy]]
*[[Emery-Dreifuss muscular dystrophy]]
Line 509: Line 211:
*[[Endocardial fibroelastosis]]
*[[Endocardial fibroelastosis]]
*[[Endomyocardial fibrosis]]
*[[Endomyocardial fibrosis]]
*[[Herbicide|endothall]] poisoning
*[[Herbicide|Endothall poisoning]]
*[[Enterococci]]
*[[Enterococci]]
*[[Epirubicin]]
*[[Epirubicin]]
Line 550: Line 252:
*[[Idiopathic dilated cardiomyopathy]]
*[[Idiopathic dilated cardiomyopathy]]
*[[Imatinib]]
*[[Imatinib]]
*[[Ixabepilone]]
*[[myocarditis]]
*[[myocarditis]]
*[[Influenza]]
*[[Influenza]]
Line 567: Line 270:
*[[Loa loa filariasis|Loa loa]]
*[[Loa loa filariasis|Loa loa]]
*[[Loeffler endocarditis]]
*[[Loeffler endocarditis]]
*[[Lyme disease]]
*[[Long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency|Long-chain Acyl CoA dehydrogenase deficiency]]
*[[Long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency|Long-chain Acyl CoA dehydrogenase deficiency]]
*[[Malaria]]
*[[Malaria]]
Line 579: Line 283:
*[[Multiple lentigines syndrome]]
*[[Multiple lentigines syndrome]]
*[[Mumps]]
*[[Mumps]]
{{col-break|width=33%}}
*[[Muscular dystrophy]]
*[[Muscular dystrophy]]
*[[Myocarditis]]
*[[Myocarditis]]
{{col-break|width=33%}}
*[[Myxomas]]
*[[Myxomas]]
*[[Naxos disease]]
*[[Naxos disease]]
Line 598: Line 302:
*[[Pheochromocytoma]]
*[[Pheochromocytoma]]
*[[Anthracyclines|Pirarubicin]]
*[[Anthracyclines|Pirarubicin]]
*Pityriasis lichenoides et varioliformis acuta (PLEVA)
*[[Pityriasis lichenoides et varioliformis acuta]]
*[[Pixantrone]]
*[[Pixantrone]]
*[[Poliomyelitis]]
*[[Poliomyelitis]]
Line 612: Line 316:
*[[Radiation]]
*[[Radiation]]
*[[Refsum disease]]
*[[Refsum disease]]
*Respiratory chain complex I deficiency
*[[NADH dehydrogenase|Respiratory chain complex I deficiency]]
*[[Rhabdomyoma]]
*[[Rhabdomyoma]]
*[[Rheumatic fever]]
*[[Rheumatic fever]]
*[[Rheumatoid arthritis]]
*[[Rheumatoid arthritis]]
*[[Rocky mountain spotted fever]]
*[[Rocky mountain spotted fever]]
*[[S-adenosylhomocysteine hydrolase]] deficiency
*[[Adenosylhomocysteinase|S-adenosylhomocysteine hydrolase deficiency]]
*[[Salih myopathy]]
*[[Salih myopathy]]
*Sarcoglycanopathy
*[[SGCG|Sarcoglycanopathy]]
*[[Sarcoidosis]]
*[[Sarcoidosis]]
*[[Sarcomas]]
*[[Sarcomas]]
*Sarcosporidiosis
*[[Sarcocystis|Sarcosporidiosis]]
*[[Schistosomiasis]]
*[[Schistosomiasis]]
*[[Scurvy]]
*[[Scurvy]]
Line 674: Line 378:
|  ||  || 2q35 || [[desmin]] || Desmin || Desmin myopathy  
|  ||  || 2q35 || [[desmin]] || Desmin || Desmin myopathy  
|-
|-
|  ||  || 5q33 || [[sarcoglycan| δ-sarcoglycan]]  || δ-sarcoglycan || [[Limb-girdle muscular dystrophy| Limb girdle muscular dystrophy 2F ]]
|  ||  || 5q33 || [[sarcoglycan| δ-sarcoglycan]]  || δ-sarcoglycan || [[Limb-girdle muscular dystrophy| Limb girdle muscular dystrophy 2F]]
|-
|-
|  ||  || 1q32 || [[Troponin T]]  || [[Troponin T]] ||  
|  ||  || 1q32 || [[Troponin T]]  || [[Troponin T]] ||  
Line 704: Line 408:
|  ||  || 2p31 || Titin || Titin ||
|  ||  || 2p31 || Titin || Titin ||
|-
|-
| [[Hypertrophic cardiomyopathy]] with [[Wolf-Parkinson-White syndrome]] ||  || 7q3 || AMPK || AMPK ||
| [[Hypertrophic cardiomyopathy]] with [[Wolff-Parkinson-White syndrome]] ||  || 7q3 || AMPK || AMPK ||
|-
|-
| ||  || MIDINA || Mitochondrial respiratory chain || Mitochondrial respiratory chain || Mitochondrial myopathy
| ||  || MIDINA || Mitochondrial respiratory chain || Mitochondrial respiratory chain || Mitochondrial myopathy
Line 716: Line 420:
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
{{WH}}
{{WS}}


[[Category:Crowdiagnosis]]
[[Category:Best pages]]
[[Category:Best pages]]
[[Category:Cardiology]]
[[Category:Cardiology]]
Line 725: Line 428:
[[Category:Up-To-Date cardiology]]
[[Category:Up-To-Date cardiology]]
[[Category:Disease]]
[[Category:Disease]]
{{WH}}
{{WS}}

Latest revision as of 03:34, 27 October 2023

Cardiomyopathy Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Cardiomyopathy from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

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CT

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Medical Therapy

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Future or Investigational Therapies

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2023 ESC Guideline Recommendations

2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy

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Cardiomyopathy causes On the Web

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Risk calculators and risk factors for Cardiomyopathy causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Edzel Lorraine Co, DMD, MD[2]

Overview

There are numerous causes of cardiomyopathies depending on the type in question. Some of the causes include: genetic (e.g. hereditary spherocytosis, familial cardiomyopathy, Friedreich's ataxia); metabolic (e.g. beriberi, Gaucher's disease, uremia); and infectious (e.g. adenovirus, african trypanosomiasis, arbovirus, ascariasis). Cardiomyopathies usually have an insidious onset but life-threatening causes including acute coronary syndrome, electrolyte imbalance, and cocaine abuse which must be identified and managed accordingly. Other common causes include alcoholism, diabetes mellitus, and hypothyroidism.

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.[1]

Common Causes

Causes by Organ System

Cardiovascular Arrhythmogenic right ventricular dysplasia, arterial calcification of infancy, Brugada syndrome, cardiac transplant rejection, cardiomyopathy-renal anomalies,[2] chronic tachycardia, coronary artery disease, cytochrome C oxidase deficiency, endomyocardial fibrosis, eosinophilic endomyocardial disease, giant cell myocarditis, hypertension, Keshan disease , left ventricular noncompaction, Loeffler endocarditis, myocarditis, Naxos disease, obesity-colitis-hypothyroidism-cardiac hypertrophy-developmental delay,[3] prolonged QT syndrome, X-linked dilated cardiomyopathy,[4] X-linked fatal infantile cardiomyopathy[5]
Chemical / poisoning Arsenic, cobalt, endothall, ethanol, lead, thallium, allylamine, carbon monoxide, toxic mushrooms
Dermatologic Familial cutaneous collagenoma,[6] lentiginosis, dermatomyositis, Carvajal-Huerta syndrome, Hand-Schuller-Christian syndrome, McLeod syndrome, multiple lentigines syndrome, Naxos disease, pityriasis lichenoides et varioliformis acuta, Refsum disease
Drug Side Effect 5-fluorouracil, aclarubicin, actinomycin D, alemtuzumab, amrubicin, bleomycin, Benzphetamine, capecitabine, certolizumab pegol, Cidofovir, cisplatin, clozapine, cyclophosphamide, Cytarabine, dasatinib, daunorubicin, Dextroamphetamine, disopyramide, Doxorubicin Hydrochloride, epirubicin, fenfluramine, hydralazine, hydroxychloroquine, idarubicin, imatinib, interferon-alpha, Interferon alfa-2b , Ixabepilone, Megestrol, mitoxantrone, paclitaxel, paracetamol, Pegylated interferon alfa-2b, pirarubicin, pixantrone, streptomycin, sunitinib, tacrolimus, Trametinib, trastuzumab, tricyclic anti-depressant abuse, Valdecoxib, valrubicin
Ear Nose Throat No underlying causes
Endocrine Acromegaly, amyloidosis, carcinoid syndrome, celiac disease, cushing syndrome, diabetes mellitus, gout, hemochromatosis, hyperparathyroidism, hyperthyroidism, hypothyroidism, obesity-colitis-hypothyroidism-cardiac hypertrophy developmental delay,[3] paraneoplastic syndromes, pheochromocytoma, pituitary tumor, WAGR syndrome, Whipple's disease
Environmental Heatstroke, hypothermia, lightning strike, radiation
Gastroenterologic Hemochromatosis, obesity-colitis-hypothyroidism-cardiac hypertrophy-developmental delay complex, [3]Whipple's disease
Genetic Alpers' disease, Borud syndrome, Brugada syndrome, Carvajal-Huerta syndrome, congenital disorders of glycosylation, congenital generalized lipodystrophy, Costello syndrome, cytochrome C oxidase deficiency, desmin-related myofibrillar myopathy, Emery-Dreifuss muscular dystrophy, familial cardiomyopathy, Friedreich's ataxia, hereditary spherocytosis, Hurler syndrome, Hutchinson-Gilford progeria syndrome, hypertrichotic osteochondrodysplasia, Keshan disease, Laing distal myopathy, LAMA2-related muscular dystrophy, mitochondrial trifunctional protein deficiency, multiple lentigines syndrome, muscular dystrophy, Naxos disease, Noonan syndrome, porphyria, prolonged QT syndrome, pseudoxanthoma elasticum, Refsum disease, respiratory chain complex I deficiency, Salih myopathy, sarcoglycanopathy, syndromic microphthalmia type 7, WAGR syndrome, X-linked dilated cardiomyopathy, [4] X-linked fatal infantile cardiomyopathy, [5] Yunis-Varon syndrome
Hematologic Hereditary spherocytosis
Iatrogenic Cardiac irradiation
Infectious Disease Adenovirus, african trypanosomiasis, arbovirus, ascariasis, aspergillosis, beta-hemolytic streptococci, blastomycosis, brucella, Chagas disease, coccidioidomycosis, coxsackie A virus, coxsackie virus B1-B5, cryptococcosis, cysticercosis, cytomegalovirus, diptheria, echovirus, enterococci, Epstein-Barr virus (EBV), filariasis, flavivirus, histoplasmosis, HIV, influenza, leishmaniasis, leptospirosis, loeffler endocarditis, Lyme disease, malaria, measles, mumps, pertussis, poliomyelitis, psittacosis, Q fever, rabies, rheumatic fever, rocky mountain spotted fever, sarcosporidiosis, schistosomiasis, staphylococcus, syphilis, tetanus, toxoplasmosis, trichinosis, tuberculosis, typhoid fever, varicella-zoster virus
Musculoskeletal / Ortho Arthrogryposis due to muscular dystrophy, cytochrome c oxidase deficiency, dermatomyositis, Duchenne muscular dystrophy, Emery-Dreifuss muscular dystrophy, Hand-Schuller-Christian Syndrome, Kearns-Sayre syndrome, mitochondrial myopathy, muscular dystrophy, myotonic dystrophy
Neurologic Alpers' disease, d-2-hydroxyglutarate dehydrogenase deficiency, Friedreich's ataxia, Hand-Schuller-Christian Syndrome, Kearns-Sayre syndrome, MELAS syndrome, Whipple's disease
Nutritional / Metabolic 3-hydroxyacyl-CoA dehydrogenase deficiency, beriberi, Borud syndrome, carbohydrate deficient glycoprotein syndrome type 1a, carnitine deficiency, Coenzyme Q10 (CoQ10) deficiency, coenzyme Q cytochrome c reductase deficiency, congenital disorder of glycosylation, cytochrome C Oxidase deficiency, d-2-hydroxyglutarate dehydrogenase deficiency, Fabry disease, gangliosidosis, Gaucher's disease, glutaric acidemia type 2, gout, hemochromatosis, Hunter syndrome, Hurler syndrome, isobutyryl-coenzyme A dehydrogenase deficiency, Keshan disease, kwashiorkor, long-chain Acyl CoA dehydrogenase deficiency, malonic aciduria, MELAS syndrome, mitochondrial trifunctional protein deficiency, mucopolysaccharidoses, Niemann-Pick disease, niacin deficiency, oxalosis, paraneoplastic syndromes, Pompe disease, porphyria, Refsum disease, respiratory chain complex I deficiency, s-adenosylhomocysteine hydrolase deficiency, scurvy, selenium deficiency, subacute necrotising encephalomyelopathy, triosephosphate isomerase deficiency, uremia, vitamin B deficiency, vitamin D overdose
Obstetric/Gynecologic Peripartum cardiomyopathy
Oncologic Angioma, myxomas, pituitary tumour, rhabdomyoma, sarcoma, leukemia, WAGR syndrome, carcinoid syndrome
Ophthalmologic Hand-Schuller-Christian syndrome, syndromic microphthalmia type 7, myotonic dystrophy, WAGR syndrome
Overdose / Toxicity Alcohol, cobalt poisoning, cocaine abuse, oxalosis, paracetamol, tricyclic antidepressant, vitamin D overdose
Psychiatric Takotsubo cardiomyopathy
Pulmonary No underlying causes
Renal / Electrolyte Cardiomyopathy-renal anomalies,[2] hypocalcemia, hypokalemia, hypomagnesemia, uremia, WAGR syndrome, MELAS syndrome
Rheum / Immune / Allergy Gout, Kawasaki disease, polyarteritis nodosa, rheumatoid arthritis, systemic sclerosis, scleroderma, systemic lupus erythematosus
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Dental No underlying causes
Miscellaneous Black widow spider bite, cardiac transplant rejection, idiopathic dilated cardiomyopathy, mitochondrial trifunctional protein deficiency, obesity, obstructive sleep apnea, stress-induced cardiomyopathy

Causes in Alphabetical Order

Cardiomyopathies and Genetics

Genetic causes of cardiomyopathies.[7]

Phenotype Inheritance Pattern Chromosomal Locus Gene Protein Skeletal Myopathy
Dilated cardiomyopathy X-linked Xp21 dystrophin Dystrophin Duchenne / Becker muscular dystrophy
X-linked Xq28 G4.5 Tafazzin Barth syndrome
Autosomal dominant 15q14 actin Actin Nemaline myopathy
2q35 desmin Desmin Desmin myopathy
5q33 δ-sarcoglycan δ-sarcoglycan Limb girdle muscular dystrophy 2F
1q32 Troponin T Troponin T
14q11 β-myosin heavy chain β-myosin heavy chain
15q2 α-tropomyosin α-tropomyosin Nemaline myopathy
Midna Mitochondrial respiratory chain Mitochondrial respiratory chain Mitochondrial myopathy
Dilated cardiomyopathy with conduction disease Autosomal dominant 1q21 lamin A/C Lamin A/C Emery-Dreifuss muscular dystrophy
Hypertrophic cardiomyopathy Autosomal dominant 14q11 β-myosin heavy chain β-myosin heavy chain
14q11 β-myosin heavy chain β-myosin heavy chain
1q32 Troponin T Troponin T
12q23 Troponin T Troponin T
15q2 α-tropomyosin α-tropomyosin Nemaline myopathy
11q11 myosin-binding protein C myosin-binding protein C
3p21 myosin essential light chain myosin essential light chain
3p21 myosin regulatory light chain myosin regulatory light chain
2p31 Titin Titin
Hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome 7q3 AMPK AMPK
MIDINA Mitochondrial respiratory chain Mitochondrial respiratory chain Mitochondrial myopathy
Left ventricular noncompaction X-linked Xq28 G4.5 Tafazzin Barth syndrome
Autosomal dominant 18q12 α-dystrobrevin α-dystrobrevin Muscular dystrophy

References

  1. ↑ Sisakian H (June 2014). "Cardiomyopathies: Evolution of pathogenesis concepts and potential for new therapies". World J Cardiol. 6 (6): 478–94. doi:10.4330/wjc.v6.i6.478. PMID 24976920.
  2. ↑ 2.0 2.1 2.2 Leask, KM.; Kerr, B.; Ladusans, E. (2007). "Cardiomyopathy with renal anomalies in two siblings: a new recessive syndrome?". Clin Dysmorphol. 16 (1): 51–3. doi:10.1097/MCD.0b013e328010caa9. PMID 17159516. Unknown parameter |month= ignored (help)
  3. ↑ 3.0 3.1 3.2 3.3 Tan, TY.; Amor, DJ. (2007). "Obesity, hypothyroidism, craniosynostosis, cardiac hypertrophy, colitis, and developmental delay: a novel syndrome". Am J Med Genet A. 143 (2): 114–8. doi:10.1002/ajmg.a.31548. PMID 17163533. Unknown parameter |month= ignored (help)
  4. ↑ 4.0 4.1 4.2 Towbin, JA.; Hejtmancik, JF.; Brink, P.; Gelb, B.; Zhu, XM.; Chamberlain, JS.; McCabe, ER.; Swift, M. (1993). "X-linked dilated cardiomyopathy. Molecular genetic evidence of linkage to the Duchenne muscular dystrophy (dystrophin) gene at the Xp21 locus". Circulation. 87 (6): 1854–65. PMID 8504498. Unknown parameter |month= ignored (help)
  5. ↑ 5.0 5.1 5.2 Gedeon, AK.; Wilson, MJ.; Colley, AC.; Sillence, DO.; Mulley, JC. (1995). "X linked fatal infantile cardiomyopathy maps to Xq28 and is possibly allelic to Barth syndrome". J Med Genet. 32 (5): 383–8. PMID 7616547. Unknown parameter |month= ignored (help)
  6. ↑ 6.0 6.1 Dawn, ME.; Deng, AC.; Petrali, J.; Wessely, C.; Jaffe, D.; Gaspari, AA. "Familial cutaneous collagenoma". Skinmed. 7 (1): 43–5. PMID 18174804.
  7. ↑ Towbin JA, Bowles NE (2002). "The failing heart". Nature. 415 (6868): 227–33. doi:10.1038/415227a. PMID 11805847. Unknown parameter |month= ignored (help)

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