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Latest revision as of 18:48, 4 September 2013

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vendhan Ramanujam M.B.B.S [2]

Synonyms and keywords: Isorhythmic AV dissociation

Overview

An atrioventricular dissociation characterized by independent and equally beating atrial and ventricular pacemakers, in the absence of a retrograde conduction from the ventricular depolarization to the atria is called as isorhythmic AV dissociation. Isorhythmic dissociation is not common in the general population and it is the most innocent type of AV dissociation.

Pathophysiology

Isorhythmic AV dissociation is a AV dissociation initiated by slowing of SA node due to sinus arrhythmia, sinus bradycardia, sinus arrest, or sinoatrial block. This allows an independent ventricular pacemaker response like either junctional rhythm (giving a normal or near normal QRS appearance and duration) or idioventricular rhythm (with a more bizarre, wide QRS) to take over the ventricles. In the presence of some degree of antegrade and retrograde atrioventricular block, there is a synchronization of independently beating sinus or atrial pacemaker with the junctional or ventricular pacemaker such that each discharges in the absolute refractory period of the other.

Both the independent atrial and ventricular rates are bradycardic and nearly identical, in contrast to other types of AV dissociation. When they both are bradycardic and synchronized, captures will not occur and a complete AV dissociation will ensue.
Both fusion beats and capture beats may be present when either the atrial or ventricular rate becomes faster than the other with antegrade or retrograde conduction.
Both P waves and the QRS complexes look related with the P wave moving closer to and then farther away from the QRS, maintaining an illusion of a normal atrioventricular conduction sequence. Occasionally, the P wave might move into and get buried within the QRS complex, only to move back out again in front of the QRS in the subsequent beats. The two pacemakers will remain independent as long as the SA node rate is bradycardic.

When this rhythm occurs intermittently with normal sinus rhythm, it is called accrochage.
When the isorhythmic dissociation is persistent, it is called as synchronization. Synchronization has two distinct patterns like, the pattern which is characterized by a rhythmic fluctuation of the interval between the P and QRS waves, most often the P wave oscillating gradually back and forth across the QRS; that is, with periodically varying of P-R and R-P intervals. In the second pattern, the P-R or R-P interval do not undergo rhythmic fluctuations, but the P and R waves are in a relatively fixed position with respect to each other.^[1]

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Common Causes

Causes by Organ System

Cardiovascular	Acute coronary syndrome, acute rheumatic fever, amyloidosis, Andersen cardiodysrhythmic periodic paralysis, Brugada syndrome, cardiac lymphoma, cardiac transplantation, cardioinhibitory syncope, complete heart block, congenital heart disease, congestive heart failure, coronary reperfusion therapy, dilated cardiomyopathy, hypertensive heart disease, hypertrophic cardiomyopathy, ischemic heart disease, Jervell and Lange-Nielsen syndrome, Lev's disease, long QT syndrome, myocardial bridging, myocardial contusion, myocardial infarction, myocardial rupture, myocarditis, NSTEMI, pericarditis, Romano-Ward syndrome, sick sinus syndrome, sinoatrial block, sinus arrest, sinus bradycardia, sinus node fibrosis, STEMI, tachycardia-bradycardia syndrome, Timothy syndrome, valvular heart disease
Chemical/Poisoning	Berberine, carbamate poisoning, grayanotoxin, organophosphate poisoning, parathion poisoning, poisonous spider bites, pyrethroid poisoning, scorpion toxin
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Acetylcholine, all-trans retinoic acid, amiodarone, anthracyclines, antiarrhythmic drugs, barbiturate, beta-blockers, bupivacaine, calcium channel blockers, carbamazepine, cholinesterase inhibitors, cimetidine, citalopram, clonidine, daunorubicin, digoxin, diltiazem, diphenhydramine, donepezil, doxorubicin, edrophonium, epirubicin, granisetron, guanethidine, halothane, idarubicin, isoprenaline, lithium, mepivacaine, mesalamine, methyldopa, methylprednisolone, nelfinavir, neostigmine, nicorandil, phenothiazine, phenytoin, procainamide, propafenone, propanolol, propofol, pyridostigmine, quinidine, remifentanil, reserpine, ropivacaine, tacrine, thiamylal, timolol, tramadol, tricyclic antidepressants, urapidil, verapamil
Ear Nose Throat	No underlying causes
Endocrine	Diabetic ketoacidosis, Hashimoto's thyroiditis, hyperthyroidism, hypothyroidism, pheochromocytoma
Environmental	Hypothermia
Gastroenterologic	Amyloidosis
Genetic	Brugada syndrome, Emery-Dreifuss muscular dystrophy, Jervell and Lange-Nielsen syndrome, Kearns-Sayre syndrome, limb-girdle muscular dystrophy type 1B (LGMD1B), long QT syndrome, muscular dystrophy, myotonic dystrophy, Romano-Ward syndrome, Timothy syndrome
Hematologic	No underlying causes
Iatrogenic	Cardiac catheterization, cardiac resynchronization therapy, cardiac transplantation, coronary artery bypass grafting, Fontan procedure, heart surgery, post lung transplantation
Infectious Disease	Acute rheumatic fever, Chagas disease, diptheria, Lyme disease, septic shock
Musculoskeletal/Orthopedic	Muscular dystrophy, myotonic dystrophy, Timothy syndrome
Neurologic	Severe brain injury
Nutritional/Metabolic	Diabetic ketoacidosis, hyperkalemia, hypermagnesemia, hypocalcemia, metabolic acidosis
Obstetric/Gynecologic	No underlying causes
Oncologic	Cardiac lymphoma
Ophthalmologic	No underlying causes
Overdose/Toxicity	No underlying causes
Psychiatric	Severe anorexia nervosa, Takotsubo cardiomyopathy
Pulmonary	Hypoxia
Renal/Electrolyte	Acute renal failure, amyloidosis
Rheumatology/Immunology/Allergy	Neonatal lupus erythematosus, scleroderma, Sjogren's syndrome
Sexual	No underlying causes
Trauma	Myocardial contusion
Urologic	No underlying causes
Miscellaneous	Idiopathic

Causes in Alphabetical Order

References

↑ Levy MN, Edflstein J (1970). "The mechanism of synchronization in isorhythmic A-V dissociation. II. Clinical studies". Circulation. 42 (4): 689–99. PMID 11993309. Unknown parameter |month= ignored (help)

Template:WH Template:WS

[pmid11993309-1] Levy MN, Edflstein J (1970). "The mechanism of synchronization in isorhythmic A-V dissociation. II. Clinical studies". Circulation. 42 (4): 689–99. PMID 11993309. Unknown parameter |month= ignored (help)

[1]

@@ Line 1: / Line 1: @@
+__NOTOC__
+{{SI}}
+{{CMG}}; {{AE}} {{VR}}
+{{SK}} Isorhythmic AV dissociation
 ==Overview==
+An [[atrioventricular dissociation]] characterized by independent and equally beating atrial and ventricular pacemakers, in the absence of a retrograde conduction from the ventricular depolarization to the atria is called as isorhythmic AV dissociation.  Isorhythmic dissociation is not common in the general population and it is the most innocent type of AV dissociation.
+==Pathophysiology==
+Isorhythmic AV dissociation is a [[AV dissociation]] initiated by slowing of [[SA node]] due to sinus arrhythmia, [[sinus bradycardia]], [[sinus arrest]], or [[sinoatrial block]].  This allows an independent ventricular pacemaker response like either [[junctional rhythm]] (giving a normal or near normal QRS appearance and duration) or [[idioventricular rhythm]] (with a more bizarre, wide QRS) to take over the ventricles.  In the presence of some degree of antegrade and retrograde [[atrioventricular block]], there is a synchronization of independently beating sinus or atrial pacemaker with the junctional or ventricular pacemaker such that each discharges in the absolute refractory period of the other.
+*Both the independent atrial and ventricular rates are [[Bradycardia|bradycardic]] and nearly identical, in contrast to other types of AV dissociation.  When they both are bradycardic and synchronized, captures will not occur and a complete AV dissociation will ensue.
+*Both [[fusion beats]] and [[capture beats]] may be present when either the atrial or ventricular rate becomes faster than the other with antegrade or retrograde conduction.
+*Both [[P waves]] and the QRS complexes look related with the P wave moving closer to and then farther away from the QRS, maintaining an illusion of a normal atrioventricular conduction sequence.  Occasionally, the P wave might move into and get buried within the QRS complex, only to move back out again in front of the QRS in the subsequent beats.  The two pacemakers will remain independent as long as the SA node rate is bradycardic.
+:*When this rhythm occurs intermittently with normal sinus rhythm, it is called accrochage.
+:*When the isorhythmic dissociation is persistent, it is called as synchronization.  Synchronization has two distinct patterns like, the pattern which is characterized by a rhythmic fluctuation of the interval between the P and QRS waves, most often the P wave oscillating gradually back and forth across the QRS; that is, with periodically varying of [[PR interval|P-R]] and R-P intervals.  In the second pattern, the P-R or R-P interval do not undergo rhythmic fluctuations, but the P and [[R waves]] are in a relatively fixed position with respect to each other.<ref name="pmid11993309">{{cite journal | author = Levy MN, Edflstein J | title = The mechanism of synchronization in isorhythmic A-V dissociation. II. Clinical studies | journal = [[Circulation]] | volume = 42 | issue = 4 | pages = 689–99 | year = 1970 | month = October | pmid = 11993309 | doi = | url = http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=11993309 | issn = }}</ref>
 ==Causes==
 ===Life Threatening Causes===
 Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
+*[[Diabetic ketoacidosis]]
+*[[Digitalis toxicity]]
+*[[Myocardial infarction]]
+*[[Myocardial rupture]]
+*[[Organophosphate poisoning]]
 ===Common Causes===
+*[[Acetylcholine]]
+*[[Acute coronary syndrome]]
+*[[Acute rheumatic fever]]
+*[[Amiodarone]]
+*[[Antiarrhythmic agents]]
+*[[Beta-blockers]]
+*[[Calcium channel blockers]]
+*[[Cardiomyopathy]]
+*[[Congestive heart failure]]
+*[[Digitalis toxicity]]
+*[[Hypertensive heart disease]]
+*[[Ischemic heart disease]]
+*[[Myocarditis]]
+*[[Sick sinus syndrome]]
+*[[Sinus arrest]]
+*[[Sinus bradycardia]]
 ===Causes by Organ System===
 {|style="width:80%; height:100px" border="1"
 |style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
-|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | [[Acute coronary syndrome]],  [[acute rheumatic fever]],  [[amyloidosis]],  [[Andersen cardiodysrhythmic periodic paralysis]],  [[Brugada syndrome]],  [[cardiac lymphoma]],  [[cardiac transplantation]],  [[cardioinhibitory syncope]],  [[complete heart block]],  [[congenital heart disease]],  [[congestive heart failure]],  [[coronary reperfusion therapy]],  [[dilated cardiomyopathy]],  [[hypertensive heart disease]],  [[hypertrophic cardiomyopathy]],  [[ischemic heart disease]],  [[Jervell and Lange-Nielsen syndrome]],  [[Lev's disease]],  [[long QT syndrome]],  [[myocardial bridging]],  [[myocardial contusion]],  [[myocardial infarction]],  [[myocardial rupture]],  [[myocarditis]],  [[NSTEMI]],  [[pericarditis]],  [[Romano-Ward syndrome]],  [[sick sinus syndrome]],  [[sinoatrial block]],  [[sinus arrest]],  [[sinus bradycardia]],  [[sinus node fibrosis]],  [[STEMI]],  [[tachycardia-bradycardia syndrome]],  [[Timothy syndrome]],  [[valvular heart disease]]
+|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | [[Acute coronary syndrome]],  [[acute rheumatic fever]],  [[amyloidosis]],  [[Andersen cardiodysrhythmic periodic paralysis]],  [[Brugada syndrome]],  [[cardiac tumor#heart in lymphomas|cardiac lymphoma]],  [[cardiac transplantation]],  [[Carotid sinus hypersensitivity|cardioinhibitory syncope]],  [[complete heart block]],  [[congenital heart disease]],  [[congestive heart failure]],  [[reperfusion injury|coronary reperfusion therapy]],  [[dilated cardiomyopathy]],  [[hypertensive heart disease]],  [[hypertrophic cardiomyopathy]],  [[ischemic heart disease]],  [[Jervell and Lange-Nielsen syndrome]],  [[Lev's disease]],  [[long QT syndrome]],  [[myocardial bridging]],  [[myocardial contusion]],  [[myocardial infarction]],  [[myocardial rupture]],  [[myocarditis]],  [[NSTEMI]],  [[pericarditis]],  [[Romano-Ward syndrome]],  [[sick sinus syndrome]],  [[sinoatrial block]],  [[sinus arrest]],  [[sinus bradycardia]],  [[sinus node disease|sinus node fibrosis]],  [[STEMI]],  [[tachycardia-bradycardia syndrome]],  [[Timothy syndrome]],  [[valvular heart disease]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Chemical/Poisoning'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Berberine]],  [[carbamate|carbamate poisoning]],  [[grayanotoxin]],  [[organophosphate|organophosphate poisoning]],  [[parathion poisoning]],  [[spider bite#spider venom|poisonous spider bites]],  [[pyrethroid|pyrethroid poisoning]],  [[Arizona bark scorpion|scorpion toxin]]
 |-
 |-bgcolor="LightSteelBlue"
@@ Line 27: / Line 63: @@
 |-bgcolor="LightSteelBlue"
 | '''Drug Side Effect'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Acetylcholine]],  [[all-trans retinoic acid]],  [[amiodarone]],  [[anthracyclines]],  [[antiarrhythmic drugs]],  [[barbiturate]],  [[beta-blockers]],  [[bupivacaine]],  [[calcium channel blockers]],  [[carbamazepine]],  [[cholinesterase inhibitors]],  [[cimetidine]],  [[citalopram]],  [[clonidine]],  [[daunorubicin]],  [[digoxin]],  [[diltiazem]],  [[diphenhydramine]],  [[donepezil]],  [[doxorubicin]],  [[edrophonium]],  [[epirubicin]],  [[granisetron]],  [[guanethidine]],  [[halothane]],  [[idarubicin]],  [[isoprenaline]],  [[lithium]],  [[mepivacaine]],  [[mesalamine]],  [[methyldopa]],  [[methylprednisolone]],  [[nelfinavir]],  [[neostigmine]],  [[nicorandil]],  [[phenothiazine]],  [[phenytoin]],  [[procainamide]],  [[propafenone]],  [[propanolol]],  [[propofol]],  [[pyridostigmine]],  [[quinidine]],  [[remifentanil]],  [[reserpine]],  [[ropivacaine]],  [[tacrine]],  [[thiamylal]],  [[timolol]],  [[tramadol]],  [[tricyclic antidepressants]],  [[urapidil]],  [[verapamil]]
 |-
 |-bgcolor="LightSteelBlue"
@@ Line 35: / Line 71: @@
 |-bgcolor="LightSteelBlue"
 | '''Endocrine'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Diabetic ketoacidosis]],  [[Hashimoto's thyroiditis]],  [[hyperthyroidism]],  [[hypothyroidism]],  [[pheochromocytoma]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Environmental'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Hypothermia]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Gastroenterologic'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Amyloidosis]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Genetic'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Brugada syndrome]],  [[Emery-Dreifuss muscular dystrophy]],  [[Jervell and Lange-Nielsen syndrome]],  [[Kearns-Sayre syndrome]],  [[Limb-girdle muscular dystrophy|limb-girdle muscular dystrophy type 1B (LGMD1B)]],  [[long QT syndrome]],  [[muscular dystrophy]],  [[myotonic dystrophy]],  [[Romano-Ward syndrome]],  [[Timothy syndrome]]
 |-
 |-bgcolor="LightSteelBlue"
@@ Line 55: / Line 91: @@
 |-bgcolor="LightSteelBlue"
 | '''Iatrogenic'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Cardiac catheterization]],  [[cardiac resynchronization therapy]],  [[cardiac transplantation]],  [[coronary artery bypass grafting]],  [[Fontan procedure]],  [[heart surgery]],  [[lung transplantation|post lung transplantation]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Infectious Disease'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Acute rheumatic fever]],  [[Chagas disease]],  [[diptheria]],  [[Lyme disease]],  [[septic shock]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Musculoskeletal/Orthopedic'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Muscular dystrophy]],  [[myotonic dystrophy]],  [[Timothy syndrome]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Neurologic'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[brain damage|Severe brain injury]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Nutritional/Metabolic'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Diabetic ketoacidosis]],  [[hyperkalemia]],  [[hypermagnesemia]],  [[hypocalcemia]],  [[metabolic acidosis]]
 |-
 |-bgcolor="LightSteelBlue"
@@ Line 79: / Line 115: @@
 |-bgcolor="LightSteelBlue"
 | '''Oncologic'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[cardiac tumor#heart in lymphomas|Cardiac lymphoma]]
 |-
 |-bgcolor="LightSteelBlue"
@@ Line 91: / Line 127: @@
 |-bgcolor="LightSteelBlue"
 | '''Psychiatric'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[anorexia nervosa|Severe anorexia nervosa]],  [[Takotsubo cardiomyopathy]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Pulmonary'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Hypoxia]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Renal/Electrolyte'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Acute renal failure]],  [[amyloidosis]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Rheumatology/Immunology/Allergy'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Neonatal lupus erythematosus]],  [[scleroderma]],  [[Sjogren's syndrome]]
 |-
 |-bgcolor="LightSteelBlue"
@@ Line 111: / Line 147: @@
 |-bgcolor="LightSteelBlue"
 | '''Trauma'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Myocardial contusion]]
 |-
 |-bgcolor="LightSteelBlue"
@@ Line 119: / Line 155: @@
 |-bgcolor="LightSteelBlue"
 | '''Miscellaneous'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Idiopathic]]
 |-
 |}
@@ Line 142: / Line 178: @@
 *[[Bupivacaine]]
 *[[Calcium channel blockers]]
-*[[Carbamate poisoning]]
+*[[carbamate|Carbamate poisoning]]
 *[[Carbamazepine]]
 *[[Cardiac catheterization]]
-*[[Cardiac lymphoma]]
+*[[cardiac tumor#heart in lymphomas|Cardiac lymphoma]]
 *[[Cardiac resynchronization therapy]]
 *[[Cardiac transplantation]]
-*[[Cardioinhibitory syncope]]
+*[[Carotid sinus hypersensitivity|Cardioinhibitory syncope]]
 *[[Chagas disease]]
 *[[Cholinesterase inhibitors]]
@@ Line 158: / Line 194: @@
 *[[Congestive heart failure]]
 *[[Coronary artery bypass grafting]]
-*[[Coronary reperfusion therapy]]
+*[[reperfusion injury|Coronary reperfusion therapy]]
 *[[Daunorubicin]]
 *[[Diabetic ketoacidosis]]
@@ Line 189: / Line 225: @@
 *[[Idarubicin]]
 *[[Idiopathic]]
-*[[Infraclavicular brachial plexus block]]
 *[[Ischemic heart disease]]
 *[[Isoprenaline]]
@@ Line 195: / Line 230: @@
 *[[Kearns-Sayre syndrome]]
 *[[Lev's disease]]
-*[[Limb-girdle muscular dystrophy type 1b]]
+*[[Limb-girdle muscular dystrophy|Limb-girdle muscular dystrophy type 1B (LGMD1B)]]
 *[[Lithium]]
 *[[Long QT syndrome]]
@@ Line 206: / Line 241: @@
 *[[Muscular dystrophy]]
 *[[Myocardial bridging]]
-*[[Myocardial contusion ]]
+*[[Myocardial contusion]]
 *[[Myocardial infarction]]
 *[[Myocardial rupture]]
@@ Line 215: / Line 250: @@
 *[[Neostigmine]]
 *[[Nicorandil]]
+*[[NSTEMI]]
 {{col-break|width=33%}}
-*[[NSTEMI]]
+*[[organophosphate|Organophosphate poisoning]]
-*[[Organophosphorus poisoning]]
 *[[Parathion poisoning]]
 *[[Pericarditis]]
@@ Line 223: / Line 258: @@
 *[[Phenytoin]]
 *[[Pheochromocytoma]]
-*[[Poisonous spider bites]]
+*[[spider bite#spider venom|Poisonous spider bites]]
-*[[Post lung transplantation]]
+*[[lung transplantation|Post lung transplantation]]
 *[[Procainamide]]
 *[[Hypothyroidism]]
@@ Line 230: / Line 265: @@
 *[[Propanolol]]
 *[[Propofol]]
-*[[Pyrethroid poisoning]]
+*[[pyrethroid|Pyrethroid poisoning]]
 *[[Pyridostigmine]]
 *[[Quinidine]]
@@ Line 238: / Line 273: @@
 *[[Ropivacaine]]
 *[[Scleroderma]]
-*[[Scorpion toxin]]
+*[[Arizona bark scorpion|Scorpion toxin]]
 *[[Septic shock]]
-*[[Severe anorexia nervosa]]
+*[[anorexia nervosa|Severe anorexia nervosa]]
-*[[Severe brain injury]]
+*[[brain damage|Severe brain injury]]
 *[[Sick sinus syndrome]]
 *[[Sinoatrial block]]
 *[[Sinus arrest]]
 *[[Sinus bradycardia]]
-*[[Sinus node fibrosis]]
+*[[sinus node disease|Sinus node fibrosis]]
 *[[Sjogren's syndrome]]
 *[[STEMI]]