Carbenicillin indanyl sodium: Difference between revisions

Latest revision as of 04:22, 2 January 2014

Carbenicillin indanyl sodium
GEOCILLIN^® FDA Package Insert
Description
Clinical Pharmacology
Microbiology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Overdosage
Dosage and Administration
How Supplied

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]

Overview

Carindacillin (INN), also known as Carbenicillin indanyl (USAN) is a penicillin antibiotic. It is a prodrug of carbenicillin.^[1]

US Brand Names

GEOCILLIN^®

FDA Package Insert

Mechanism of Action

Carbenicillin exerts its antibacterial activity by interference with final cell wall synthesis of susceptible bacteria. The antibacterial activity of Geocillin is due to its rapid conversion to carbenicillin by hydrolysis after absorption. Though Geocillin provides substantial in vitro activity against a variety of both gram-positive and gram-negative microorganisms, the most important aspect of its profile is in its antipseudomonal and antiproteal activity.^[2]

References

↑ English AR, Retsema JA, Ray VA, Lynch JE (1972). "Carbenicillin indanyl sodium, an orally active derivative of carbenicillin". Antimicrob. Agents Chemother. 1 (3): 185–91. PMC 444190. PMID 4558137. Unknown parameter |month= ignored (help)
↑ "GEOCILLIN (CARBENICILLIN INDANYL SODIUM) TABLET, FILM COATED [ROERIG]". Text " accessdate" ignored (help)

[pmid4558137-1] English AR, Retsema JA, Ray VA, Lynch JE (1972). "Carbenicillin indanyl sodium, an orally active derivative of carbenicillin". Antimicrob. Agents Chemother. 1 (3): 185–91. PMC 444190. PMID 4558137. Unknown parameter |month= ignored (help)

[dailymed.nlm.nih.gov-2] "GEOCILLIN (CARBENICILLIN INDANYL SODIUM) TABLET, FILM COATED [ROERIG]". Text " accessdate" ignored (help)

[1]

[2]

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 __NOTOC__
-{{XXXXX}}
+{{Carbenicillin Indanyl Sodium}}
-{{CMG}}
+{{CMG}}; {{AE}} {{MM}}
 ==Overview==
+'''Carindacillin''' ([[International Nonproprietary Name|INN]]), also known as '''Carbenicillin indanyl''' ([[United States Adopted Name|USAN]]) is a [[penicillins|penicillin]] [[antibiotic]]. It is a [[prodrug]] of [[carbenicillin]].<ref name="pmid4558137">{{cite journal |author=English AR, Retsema JA, Ray VA, Lynch JE |title=Carbenicillin indanyl sodium, an orally active derivative of carbenicillin |journal=Antimicrob. Agents Chemother. |volume=1 |issue=3 |pages=185–91 |year=1972 |month=March |pmid=4558137 |pmc=444190 |doi= |url=http://aac.asm.org/cgi/pmidlookup?view=long&pmid=4558137}}</ref>
 ==Category==
+[[penicillins|penicillin]] [[antibiotic]]
 ==US Brand Names==
-geocillin<sup>®</sup>
+GEOCILLIN<sup>®</sup>
 ==FDA Package Insert==
-'''[[XXXXX description|Description]]'''
+'''[[Carbenicillin indanyl sodium description|Description]]'''
-'''| [[XXXXX clinical pharmacology|Clinical Pharmacology]]'''
+'''| [[Carbenicillin indanyl sodium clinical pharmacology|Clinical Pharmacology]]'''
-'''| [[XXXXX microbiology|Microbiology]]'''
+'''| [[Carbenicillin indanyl sodium microbiology|Microbiology]]'''
-'''| [[XXXXX indications and usage|Indications and Usage]]'''
+'''| [[Carbenicillin indanyl sodium indications and usage|Indications and Usage]]'''
-'''| [[XXXXX contraindications|Contraindications]]'''
+'''| [[Carbenicillin indanyl sodium contraindications|Contraindications]]'''
-'''| [[XXXXX warnings and precautions|Warnings and Precautions]]'''
+'''| [[Carbenicillin indanyl sodium warnings and precautions|Warnings and Precautions]]'''
-'''| [[XXXXX adverse reactions|Adverse Reactions]]'''
+'''| [[Carbenicillin indanyl sodium adverse reactions|Adverse Reactions]]'''
-'''| [[XXXXX overdosage|Overdosage]]'''
+'''| [[Carbenicillin indanyl sodium overdosage|Overdosage]]'''
-'''| [[XXXXX clinical studies|Clinical Studies]]'''
+'''| [[Carbenicillin indanyl sodium dosage and administration|Dosage and Administration]]'''
-'''| [[XXXXX dosage and administration|Dosage and Administration]]'''
+'''| [[Carbenicillin indanyl sodium how supplied|How Supplied]]'''
-'''| [[XXXXX compatibility reconstitution and stability|Compatibility, Reconstitution, and Stability]]'''
-'''| [[XXXXX directions for use|Directions For Use]]'''
-'''| [[XXXXX how supplied|How Supplied]]'''
-'''| [[XXXXX labels and packages|Labels and Packages]]'''
 ==Mechanism of Action==
+Carbenicillin exerts its antibacterial activity by interference with final cell wall synthesis of susceptible bacteria.  The antibacterial activity of Geocillin is due to its rapid conversion to carbenicillin by hydrolysis after absorption. Though Geocillin provides substantial in vitro activity against a variety of both gram-positive and gram-negative microorganisms, the most important aspect of its profile is in its antipseudomonal and antiproteal activity.<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = GEOCILLIN (CARBENICILLIN INDANYL SODIUM) TABLET, FILM COATED [ROERIG] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=02010995-9826-4a67-945b-f3022e6081df | publisher =  | date =  | accessdate}}</ref>
 ==References==