Lung cancer screening: Difference between revisions

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{{Lung cancer}}
{{Lung cancer}}


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{{CMG}} {{AE}}  


==Overview==
==Overview==
'''Lung cancer screening''' is a strategy used to identify early [[lung cancer]] in people, before they develop symptoms. [[Screening (medicine)|Screening]] refers to the use of medical tests to detect disease in asymptomatic people. Screening studies have only been done in high risk populations, such as smokers and workers with occupational exposure to certain substances. This is because radiation exposure from screening could actually induce carcinogenesis|cancer formation in a small percentage of screened subjects, so this risk should be mitigated by a (relatively) high prevalence of lung cancer in the population being screened.
Lung cancer [[Screening (medicine)|screening]] is a strategy used to identify early lung cancer in people, before they develop [[Symptom|symptoms]]. [[Screening (medicine)|Screening]] refers to the use of [[Medicine|medical]] [[Test|tests]] to detect [[disease]] in [[asymptomatic]] people. [[Screening (medicine)|Screening]] studies for lung cancer have only been done in high risk populations, such as [[Smoking|smokers]] and workers with occupational exposure to certain substances. This is because [[radiation exposure]] from [[Screening (medicine)|screening]] could actually induce [[carcinogenesis]] in a small percentage of [[Screening|screened]] subjects, so this risk should be mitigated by a (relatively) high [[prevalence]] of lung cancer in the population being [[Screening|screened]]. A [[pulmonary nodule]] larger than 5 - 6 mm is considered a positive result for [[Screening (medicine)|screening]] with [[x-ray]] or [[computed tomography]].


A pulmonary nodule larger than 5 to 6 mm is considered a positive result for screening with [[x-ray computed tomography]] .<ref name="pmid23420233">{{cite journal| author=Henschke CI, Yip R, Yankelevitz DF, Smith JP, International Early Lung Cancer Action Program Investigators*| title=Definition of a positive test result in computed tomography screening for lung cancer: a cohort study. | journal=Ann Intern Med | year= 2013 | volume= 158 | issue= 4 | pages= 246-52 | pmid=23420233 | doi=10.7326/0003-4819-158-4-201302190-00004 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23420233 }} </ref>
About 50% of smokers meet the criteria of 20 pack years<ref name="pmid31369038">{{cite journal| author=| title=Error in Results. | journal=JAMA Oncol | year= 2019 | volume= 5 | issue= 9 | pages= 1372 | pmid=31369038 | doi=10.1001/jamaoncol.2019.3296 | pmc=6681549 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31369038 }} </ref>.


==Practice guidelines==
Uptake of lung cancer screening is low<ref name="pmid36409492">{{cite journal| author=Liu Y, Pan IE, Tak HJ, Vlahos I, Volk R, Shih YT| title=Assessment of Uptake Appropriateness of Computed Tomography for Lung Cancer Screening According to Patients Meeting Eligibility Criteria of the US Preventive Services Task Force. | journal=JAMA Netw Open | year= 2022 | volume= 5 | issue= 11 | pages= e2243163 | pmid=36409492 | doi=10.1001/jamanetworkopen.2022.43163 | pmc=9679877 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=36409492  }} </ref>.
* In 2013, a clinical practice guideline by the U.S. Preventive Services Task Force ([[USPSTF]]) recommended screening for lung cancer among smokers and former smokers who are age 55 to 80 and who have smoked for 30 pack-years or more and either continue to smoke or have quit within the past 15 years.


* [[Clinical practice guideline]]s issued by the [[American College of Chest Physicians]] in 2013 recommend:<ref name="pmid23649455">{{cite journal| author=Detterbeck FC, Mazzone PJ, Naidich DP, Bach PB| title=Screening for Lung Cancer: Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. | journal=Chest | year= 2013 | volume= 143 | issue= 5 Suppl | pages= e78S-92S | pmid=23649455 | doi=10.1378/chest.12-2350 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23649455 }} [http://general-medicine.jwatch.org/cgi/content/full/2013/522/2 Summary in JournalWatch]</ref>
As of 2021, screening for lung cancer is not an implemented quality measure nor reportable<ref name="pmid35404673">{{cite journal| author=Kane GC, Barta JA, Shusted CS, Evans NR| title=Now Is the Time to Make Screening for Lung Cancer Reportable. | journal=Ann Intern Med | year= 2022 | volume= 175 | issue= 6 | pages= 888-889 | pmid=35404673 | doi=10.7326/M22-0142 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=35404673 }} </ref>.
:"For smokers and former smokers who are age 55 to 74 and who have smoked for 30 pack-years or more and either continue to smoke or have quit within the past 15 years, we suggest that annual screening with LDCT should be offered in settings that can deliver the comprehensive care provided to NLST participants."


* In 2007, a [[clinical practice guideline]] by [[American College of Chest Physicians]] recommended not to screen for lung cancer.<ref name="pmid17873156">{{cite journal |author=Alberts WM |title=Diagnosis and Management of Lung Cancer Executive Summary: ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition) |journal= |volume=132 |issue=3_suppl |pages=1S–19S |year=2007 |pmid=17873156 |doi=10.1378/chest.07-1860}}</ref>
==Screening==
===Practice Guidelines===


* In 2004, a clinical practice guideline by the [http://www.ahrq.gov/clinic/uspstfix.htm U.S. Preventive Services Task Force (USPSTF)] gave a [http://www.ahrq.gov/clinic/3rduspstf/ratings.htm grade I recommendation] indicating that "the evidence is insufficient to recommend for or against screening asymptomatic persons for lung cancer".<ref name="pmid15126258">{{cite journal |author=U.S. Preventive Services Task Force |title=Lung cancer screening: recommendation statement |journal=Ann. Intern. Med. |volume=140 |issue=9 |pages=738-9 |year=2004 |pmid=15126258 |doi=|url=http://www.annals.org/cgi/content/full/140/9/738}}</ref><ref name="pmid15126259">{{cite journal |author=Humphrey LL, Teutsch S, Johnson M |title=Lung cancer screening with sputum cytologic examination, chest radiography, and computed tomography: an update for the U.S. Preventive Services Task Force |journal=Ann. Intern. Med. |volume=140 |issue=9 |pages=740-53 |year=2004 |pmid=15126259 |doi=|url=http://www.annals.org/cgi/content/full/140/9/740}}</ref>
====Current Guidelines====
In 2021, a [[clinical practice guideline]] by the [[USPSTF|U.S. Preventive Services Task Force (USPSTF)]] recommended [[Screening (medicine)|screening]] for lung cancer among [[Smoking|smokers]] and former [[Smoking|smokers]] who are between 50 to 80 years old and who have [[Smoking|smoked]] 20 [[Pack year|pack years]] or more and either continue to [[Smoking|smoke]] or have quit [[smoking]] within the past 15 years (grade B recommendation).<ref name="www.uspreventiveservicestaskforce.org2021">{{Cite web  | last =  | first = | title = Lung Cancer: Screening | url = https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/lung-cancer-screening | publisher = | date = MRCH 9, 2021 | accessdate = Sept 15,2022 }}</ref>


==Studies of efficacy==
MEDICARE requires that screening include counseling for the benefits of screening and smoking cessation<ref>Screening for Lung Cancer with Low Dose Computed Tomography (LDCT). https://www.cms.gov/medicare-coverage-database/view/ncacal-decision-memo.aspx?proposed=N&ncaid=304</ref>.
Regular chest radiography and sputum examination programs were not effective in reducing mortality from lung cancer.<ref name="pmid14973979">{{cite journal |author=Manser RL, Irving LB, Stone C, Byrnes G, Abramson M, Campbell D |title=Screening for lung cancer |journal=Cochrane database of systematic reviews (Online) |volume= |issue=1 |pages=CD001991 |year=2004 |pmid=14973979 |doi=10.1002/14651858.CD001991.pub2}}</ref> Earlier studies (Mayo Lung Project and Czechoslovakia lung cancer screening study, combining over 17,000 smokers) showed earlier detection of lung cancer was possible but mortality was not improved. Simply detecting a tumor at an earlier stage may not necessarily yield improved mortality. For example, plain radiography resulted in increased time from diagnosis of cancer until death and those cancers being detected by screening tended to be earlier stages. However, these patients continued to die at the same rate as those who are not screened. At present, no professional or specialty organization advocates screening for lung cancer outside of clinical trials.


A computed tomography (CT) scan can uncover tumors not yet visible on an X-ray. CT scanning is now being actively evaluated as a screening tool for lung cancer in high risk patients, and it is showing promising results. The USA-based National Cancer Institute is currently completing a randomized trial comparing CT scans with chest radiographs. Several single-institution trials are ongoing around the world.


The International Early Lung Cancer Action Project  published the results of CT screening on over 31,000 high-risk patients in late 2006 in the New England Journal of Medicine.<ref name="pmid17065637">{{cite journal |author=Henschke CI, Yankelevitz DF, Libby DM, Pasmantier MW, Smith JP, Miettinen OS |title=Survival of patients with stage I lung cancer detected on CT screening |journal=N. Engl. J. Med. |volume=355 |issue=17 |pages=1763-71 |year=2006 |pmid=17065637 |doi=10.1056/NEJMoa060476}}</ref> In this study 85% of the 484 detected lung cancers were stage I and thus highly treatable. Mathematically these stage I patients would have an expected 10-year survival of 88%. However, there was no randomization of patients (all received CT scans and there was no comparison group receiving only x-rays) and the patients were not actually followed out to 10 years post detection (the median followup was 40 months).
====Previous Guidelines====


In contrast, a March 2007 study in JAMA found no benefit..<ref name="pmid17341709">{{cite journal |author=Bach PB, Jett JR, Pastorino U, Tockman MS, Swensen SJ, Begg CB |title=Computed tomography screening and lung cancer outcomes |journal=JAMA |volume=297 |issue=9 |pages=953-61 |year=2007 |pmid=17341709 |doi=10.1001/jama.297.9.953}}</ref> 3,200 current or former smokers were screened for 4 years and offered 3 or 4 CT scans. Lung cancer diagnoses were 3 times as high, and surgeries were 10 times as high, as predicted by a model, but there were no significant differences between observed and expected numbers of advanced cancers or deaths.<ref name=Crestanello_2004>{{cite journal |author=Crestanello JA, Allen MS, Jett J, Cassivi SD, et al. |title=Thoracic surgical operations in patients enrolled in a computed tomographic screening trial |journal=Journal of Thoracic and Cardiovascular Surgery |volume=128 |issue=2 |pages=254-259 |year=2004 |pmid=15282462}}</ref>  
* In 2013, a [[clinical practice guideline]] by the [[USPSTF|U.S. Preventive Services Task Force (USPSTF)]] recommended [[Screening (medicine)|screening]] for lung cancer among [[Smoking|smokers]] and former [[Smoking|smokers]] who are between 55 to 80 years old and who have [[Smoking|smoked]] 30 [[Pack year|pack years]] or more and either continue to [[Smoking|smoke]] or have quit [[smoking]] within the past 15 years (grade B recommendation).<ref name="www.uspreventiveservicestaskforce.org">{{Cite web  | last =  | first =  | title = http://www.uspreventiveservicestaskforce.org/uspstf13/lungcan/lungcanfinalrs.htm | url = http://www.uspreventiveservicestaskforce.org/uspstf13/lungcan/lungcanfinalrs.htm | publisher =  | date =  | accessdate = 31 December 2013 }}</ref>
* The [[USPSTF guidelines|USPSTF guideline]] was based on a modeling [[Clinical study|study]] using data from the National Lung Screening Trial (NLST) and Prostate, Lung, Colorectal, and Ovarian Cancer Screening (PLCO) [[randomized controlled trial]]s . The modeling study did not include the MILD [[randomized controlled trial]] that suggested harm.<ref name="pmid24379002">{{cite journal| author=de Koning HJ, Meza R, Plevritis SK, ten Haaf K, Munshi VN, Jeon J et al.| title=Benefits and harms of computed tomography lung cancer screening strategies: a comparative modeling study for the U.S. Preventive Services Task Force. | journal=Ann Intern Med | year= 2014 | volume= 160 | issue= 5 | pages= 311-20 | pmid=24379002 | doi=10.7326/M13-2316 | pmc=4116741 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24379002  }} </ref><ref name="pmid25372087">{{cite journal| author=Black WC, Gareen IF, Soneji SS, Sicks JD, Keeler EB, Aberle DR et al.| title=Cost-effectiveness of CT screening in the National Lung Screening Trial. | journal=N Engl J Med | year= 2014 | volume= 371 | issue= 19 | pages= 1793-802 | pmid=25372087 | doi=10.1056/NEJMoa1312547 | pmc=4335305 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25372087  }} [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=&cmd=prlinks&id=25715973 Review in: Evid Based Med. 2015 Apr;20(2):78] </ref><ref name="pmid22031728">{{cite journal| author=Oken MM, Hocking WG, Kvale PA, Andriole GL, Buys SS, Church TR et al.| title=Screening by chest radiograph and lung cancer mortality: the Prostate, Lung, Colorectal, and Ovarian (PLCO) randomized trial. | journal=JAMA | year= 2011 | volume= 306 | issue= 17 | pages= 1865-73 | pmid=22031728 | doi=10.1001/jama.2011.1591 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22031728  }}  [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=&cmd=prlinks&id=22345033 Review in: Evid Based Med. 2012 Oct;17(5):149-50]  [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=&cmd=prlinks&id=22431694 Review in: Ann Intern Med. 2012 Mar 20;156(6):JC3-8] </ref><ref name="pmid22465911">{{cite journal| author=Pastorino U, Rossi M, Rosato V, Marchianò A, Sverzellati N, Morosi C et al.| title=Annual or biennial CT screening versus observation in heavy smokers:  5-year results of the MILD trial. | journal=Eur J Cancer Prev | year= 2012 | volume= 21 | issue= 3 | pages= 308-15 | pmid=22465911 | doi=10.1097/CEJ.0b013e328351e1b6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22465911  }} </ref>.


Randomized controlled studies are underway in this area to see if decreased long-term mortality can be directly observed from CT screening.<ref name="pmid15603850">{{cite journal |author=Gohagan JK, Marcus PM, Fagerstrom RM, ''et al'' |title=Final results of the Lung Screening Study, a randomized feasibility study of spiral CT versus chest X-ray screening for lung cancer |journal=Lung Cancer |volume=47 |issue=1 |pages=9-15 |year=2005 |pmid=15603850 |doi=10.1016/j.lungcan.2004.06.007}}</ref>
* [[Clinical practice guideline]]s issued by the [[American College of Chest Physicians]] in 2013 recommend:<ref name="pmid23649455">{{cite journal| author=Detterbeck FC, Mazzone PJ, Naidich DP, Bach PB| title=Screening for Lung Cancer: Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. | journal=Chest | year= 2013 | volume= 143 | issue= 5 Suppl | pages= e78S-92S | pmid=23649455 | doi=10.1378/chest.12-2350 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23649455  }} [http://general-medicine.jwatch.org/cgi/content/full/2013/522/2 Summary in JournalWatch]</ref> <ref name="Midthun2016">{{cite journal|last1=Midthun|first1=David E.|title=Early detection of lung cancer|journal=F1000Research|volume=5|year=2016|pages=739|issn=2046-1402|doi=10.12688/f1000research.7313.1}}</ref><ref name="Midthun2011">{{cite journal|last1=Midthun|first1=David E.|title=Screening for Lung Cancer|journal=Clinics in Chest Medicine|volume=32|issue=4|year=2011|pages=659–668|issn=02725231|doi=10.1016/j.ccm.2011.08.014}}</ref>
** For [[Smoking|smokers]] and former [[Smoking|smokers]] who are between the age of 55 to 74 years and who have [[Smoking|smoked]] for 30 [[Pack year|pack years]] or more and either continue to [[Smoking|smoke]] or have quit within the past 15 years, it was suggested that annual [[Screening (medicine)|screening]] with low dose [[computed tomography]] (LDCT) should be offered in settings that can deliver the comprehensive care provided to the National Lung Screening Trial (NLST) participants.


==Screening for Lung Cancer U.S. Preventive Services Task Force Recommendation Statement 2013==
* In 2004, a [[clinical practice guideline]] by the [http://www.ahrq.gov/clinic/uspstfix.htm U.S. Preventive Services Task Force (USPSTF)] gave a [http://www.ahrq.gov/clinic/3rduspstf/ratings.htm grade I recommendation] [[Indication (medicine)|indicating]] that "the evidence is insufficient to recommend for or against [[Screening (medicine)|screening]] [[asymptomatic]] persons for lung cancer".<ref name="pmid15126258">{{cite journal |author=U.S. Preventive Services Task Force |title=Lung cancer screening: recommendation statement |journal=Ann. Intern. Med. |volume=140 |issue=9 |pages=738-9 |year=2004 |pmid=15126258 |doi=|url=http://www.annals.org/cgi/content/full/140/9/738}}</ref><ref name="pmid15126259">{{cite journal |author=Humphrey LL, Teutsch S, Johnson M |title=Lung cancer screening with sputum cytologic examination, chest radiography, and computed tomography: an update for the U.S. Preventive Services Task Force |journal=Ann. Intern. Med. |volume=140 |issue=9 |pages=740-53 |year=2004 |pmid=15126259 |doi=|url=http://www.annals.org/cgi/content/full/140/9/740}}</ref>
{|class="wikitable"
 
* In 2007, a [[clinical practice guideline]] by [[American College of Chest Physicians]] recommended not to [[Screening|screen]] for lung cancer.<ref name="pmid17873156">{{cite journal |author=Alberts WM |title=Diagnosis and Management of Lung Cancer Executive Summary: ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition) |journal= |volume=132 |issue=3_suppl |pages=1S–19S |year=2007 |pmid=17873156 |doi=10.1378/chest.07-1860}}</ref>
 
===Interpreting results ===
 
[https://www.acr.org/-/media/ACR/Files/RADS/Lung-RADS/LungRADSAssessmentCategoriesv1-1.pdf Lung-RADS version 1.1] by the American [https://www.acr.org College of Radiology] guides interpretation of scans.
 
The Swenson prediction rule can aid prediction<ref>Pulmonary nodule - probability of malignancy using Mayo Clinic model. Avalable at http://openrules.github.io/</ref>.
 
===Studies of Efficacy===
 
* Regular [[Chest X-ray|chest radiography]] and [[sputum]] [[examination]] programs were not effective in reducing [[mortality]] from lung cancer.<ref name="pmid14973979">{{cite journal |author=Manser RL, Irving LB, Stone C, Byrnes G, Abramson M, Campbell D |title=Screening for lung cancer |journal=Cochrane database of systematic reviews (Online) |volume= |issue=1 |pages=CD001991 |year=2004 |pmid=14973979 |doi=10.1002/14651858.CD001991.pub2}}</ref>
*Earlier [[Clinical study|studies]] (Mayo Lung Project and Czechoslovakia lung cancer [[Screening (medicine)|screening]] [[Clinical study|study]], combining over 17,000 [[Smoking|smokers]]) showed that earlier detection of lung cancer was possible but without any improvement in [[mortality]].
*At present, no professional or specialty organization advocates [[Screening (medicine)|screening]] for lung cancer outside of [[Clinical trial|clinical trials]].
 
* A [[Computed tomography|computed tomography (CT) scan]] can uncover [[Tumor|tumors]] not yet visible on an [[X-rays|X-ray]].
*[[Computed tomography|CT scanning]] is now being actively evaluated as a [[Screening (medicine)|screening]] tool for lung cancer in high risk [[Patient|patients]], and it is showing promising results.
*The USA-based National Cancer Institute is currently completing a [[randomized trial]] comparing [[Computed tomography|CT scans]] with [[Chest X-ray|chest radiographs]]. Several single-institution [[Clinical trial|trials]] are ongoing around the world.<ref name="pmid23420233">{{cite journal| author=Henschke CI, Yip R, Yankelevitz DF, Smith JP, International Early Lung Cancer Action Program Investigators*| title=Definition of a positive test result in computed tomography screening for lung cancer: a cohort study. | journal=Ann Intern Med | year= 2013 | volume= 158 | issue= 4 | pages= 246-52 | pmid=23420233 | doi=10.7326/0003-4819-158-4-201302190-00004 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23420233  }} </ref>
 
* The International Early Lung Cancer Action Project is a [[cohort study]] of 31,000 high-risk [[Patient|patients]] that found benefit from [[Screening (medicine)|screening]].<ref name="pmid17065637">{{cite journal |author=Henschke CI, Yankelevitz DF, Libby DM, Pasmantier MW, Smith JP, Miettinen OS |title=Survival of patients with stage I lung cancer detected on CT screening |journal=N. Engl. J. Med. |volume=355 |issue=17 |pages=1763-71 |year=2006 |pmid=17065637 |doi=10.1056/NEJMoa060476}}</ref>
**In this [[Clinical study|study]] 85% of the 484 detected lung cancers were [[Cancer staging|stage I]] and thus highly treatable. Mathematically, these [[Cancer staging|stage I]] [[Patient|patients]] would have an expected 10-year survival of 88%. However, there was no randomization of [[Patient|patients]] (all received [[Computed tomography|CT scans]] and there was no comparison group receiving only [[x-rays]]) and the [[Patient|patients]] were not actually followed up to 10 years post detection (the [[median]] follow up was 40 months).
 
* A [[cohort]] of 3,200 current or former [[Smoking|smokers]] found no benefit. These [[Patient|patients]] were [[Screening (medicine)|screened]] for 4 years and offered 3 or 4 [[Computed tomography|CT scans]]. Lung cancer [[Diagnosis|diagnoses]] were 3 times as high, and [[Surgery|surgeries]] were 10 times as high, as predicted by a model, but there were no significant differences between observed and expected numbers of advanced [[Cancer|cancers]] or deaths.<ref name="pmid17341709">{{cite journal |author=Bach PB, Jett JR, Pastorino U, Tockman MS, Swensen SJ, Begg CB |title=Computed tomography screening and lung cancer outcomes |journal=JAMA |volume=297 |issue=9 |pages=953-61 |year=2007 |pmid=17341709 |doi=10.1001/jama.297.9.953}}</ref>
 
* The National Lung Screening Trial (NLST) reported reduction in the [[diagnosis]] of advanced-stage [[Cancer|cancers]].<ref name="pmid24004119">{{cite journal| author=Aberle DR, DeMello S, Berg CD, Black WC, Brewer B, Church TR et al.| title=Results of the two incidence screenings in the National Lung Screening Trial. | journal=N Engl J Med | year= 2013 | volume= 369 | issue= 10 | pages= 920-31 | pmid=24004119 | doi=10.1056/NEJMoa1208962 | pmc=PMC4307922 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24004119  }} </ref>
* The DANTE trial has been inconclusive.<ref name="pmid25760561">{{cite journal| author=Infante M, Cavuto S, Lutman FR, Passera E, Chiarenza M, Chiesa G et al.| title=Long-Term Follow-up Results of the DANTE Trial, a Randomized Study of Lung Cancer Screening with Spiral Computed Tomography. | journal=Am J Respir Crit Care Med | year= 2015 | volume= 191 | issue= 10 | pages= 1166-75 | pmid=25760561 | doi=10.1164/rccm.201408-1475OC | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25760561  }} </ref>
 
===Screening for Lung Cancer U.S. Preventive Services Task Force Recommendation Statement 2013 (DO NOT EDIT)<ref name="www.uspreventiveservicestaskforce.org">{{Cite web  | last =  | first =  | title = http://www.uspreventiveservicestaskforce.org/uspstf13/lungcan/lungcanfinalrs.htm | url = http://www.uspreventiveservicestaskforce.org/uspstf13/lungcan/lungcanfinalrs.htm | publisher =  | date =  | accessdate = 31 December 2013 }}</ref>===
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| bgcolor="LightGreen"|<nowiki>"</nowiki>'''1.''' The USPSTF recommends annual screening for lung cancer with low-dose [[CT|computed tomography]] (LDCT) in adults aged 55 to 80 years who have a 30 pack-year [[smoking]] history and currently smoke or have quit within the past 15 years.  Screening should be discontinued once a person has not smoked for 15 years or develops a health problem that substantially limits life expectancy or the ability or willingness to have curative lung surgery. ''([[USPSTF guidelines classification scheme#Evidence Quality Rating|Grade B]])''<nowiki>"</nowiki>
| bgcolor="LightGreen" |<nowiki>"</nowiki>'''1.''' The USPSTF recommends annual screening for lung cancer with low-dose [[CT|computed tomography]] (LDCT) in adults aged 55 to 80 years who have a 30 pack-year [[smoking]] history and currently smoke or have quit within the past 15 years.  Screening should be discontinued once a person has not smoked for 15 years or develops a health problem that substantially limits life expectancy or the ability or willingness to have curative lung surgery. ''([[USPSTF guidelines classification scheme#Evidence Quality Rating|Grade B]])''<nowiki>"</nowiki>
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|}
===Cost-effectiveness===
The cost per year of life save from [[smoking cessation]]<ref name="pmid9388153">{{cite journal| author=Cromwell J, Bartosch WJ, Fiore MC, Hasselblad V, Baker T| title=Cost-effectiveness of the clinical practice recommendations in the AHCPR guideline for smoking cessation. Agency for Health Care Policy and Research. | journal=JAMA | year= 1997 | volume= 278 | issue= 21 | pages= 1759-66 | pmid=9388153 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9388153  }} </ref><ref name="pmid16706571">{{cite journal| author=Kaper J, Wagena EJ, van Schayck CP, Severens JL| title=Encouraging smokers to quit: the cost effectiveness of reimbursing the costs of smoking cessation treatment. | journal=Pharmacoeconomics | year= 2006 | volume= 24 | issue= 5 | pages= 453-64 | pmid=16706571 | doi=10.2165/00019053-200624050-00004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16706571  }} </ref> is less than the costs per year of life saved from screening for lung cancer with low-dose [[computed tomography]]<ref name="pmid31683314">{{cite journal| author=Criss SD, Cao P, Bastani M, Ten Haaf K, Chen Y, Sheehan DF et al.| title=Cost-Effectiveness Analysis of Lung Cancer Screening in the United States: A Comparative Modeling Study. | journal=Ann Intern Med | year= 2019 | volume=  | issue=  | pages=  | pmid=31683314 | doi=10.7326/M19-0322 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31683314  }} </ref><ref name="pmid25372087">{{cite journal| author=Black WC, Gareen IF, Soneji SS, Sicks JD, Keeler EB, Aberle DR et al.| title=Cost-effectiveness of CT screening in the National Lung Screening Trial. | journal=N Engl J Med | year= 2014 | volume= 371 | issue= 19 | pages= 1793-802 | pmid=25372087 | doi=10.1056/NEJMoa1312547 | pmc=4335305 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25372087  }}  [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=&cmd=prlinks&id=25715973 Review in: Evid Based Med. 2015 Apr;20(2):78] </ref>.
== References ==
== References ==
{{Reflist|2}}
{{Reflist|2}}
[[Category:Disease]]
[[Category:Disease]]
[[Category:Types of cancer]]
[[Category:Types of cancer]]
[[Category:Pulmonology]]
[[Category:Pulmonology]]
[[Category:Lung cancer]]
[[Category:Lung cancer]]
[[Category:Oncology]]


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[[Category:Up-To-Date]]
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Latest revision as of 07:39, 14 January 2023

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Overview

Lung cancer screening is a strategy used to identify early lung cancer in people, before they develop symptoms. Screening refers to the use of medical tests to detect disease in asymptomatic people. Screening studies for lung cancer have only been done in high risk populations, such as smokers and workers with occupational exposure to certain substances. This is because radiation exposure from screening could actually induce carcinogenesis in a small percentage of screened subjects, so this risk should be mitigated by a (relatively) high prevalence of lung cancer in the population being screened. A pulmonary nodule larger than 5 - 6 mm is considered a positive result for screening with x-ray or computed tomography.

About 50% of smokers meet the criteria of 20 pack years[1].

Uptake of lung cancer screening is low[2].

As of 2021, screening for lung cancer is not an implemented quality measure nor reportable[3].

Screening

Practice Guidelines

Current Guidelines

In 2021, a clinical practice guideline by the U.S. Preventive Services Task Force (USPSTF) recommended screening for lung cancer among smokers and former smokers who are between 50 to 80 years old and who have smoked 20 pack years or more and either continue to smoke or have quit smoking within the past 15 years (grade B recommendation).[4]

MEDICARE requires that screening include counseling for the benefits of screening and smoking cessation[5].


Previous Guidelines

Interpreting results

Lung-RADS version 1.1 by the American College of Radiology guides interpretation of scans.

The Swenson prediction rule can aid prediction[17].

Studies of Efficacy

  • The International Early Lung Cancer Action Project is a cohort study of 31,000 high-risk patients that found benefit from screening.[20]
    • In this study 85% of the 484 detected lung cancers were stage I and thus highly treatable. Mathematically, these stage I patients would have an expected 10-year survival of 88%. However, there was no randomization of patients (all received CT scans and there was no comparison group receiving only x-rays) and the patients were not actually followed up to 10 years post detection (the median follow up was 40 months).
  • A cohort of 3,200 current or former smokers found no benefit. These patients were screened for 4 years and offered 3 or 4 CT scans. Lung cancer diagnoses were 3 times as high, and surgeries were 10 times as high, as predicted by a model, but there were no significant differences between observed and expected numbers of advanced cancers or deaths.[21]
  • The National Lung Screening Trial (NLST) reported reduction in the diagnosis of advanced-stage cancers.[22]
  • The DANTE trial has been inconclusive.[23]

Screening for Lung Cancer U.S. Preventive Services Task Force Recommendation Statement 2013 (DO NOT EDIT)[6]

"1. The USPSTF recommends annual screening for lung cancer with low-dose computed tomography (LDCT) in adults aged 55 to 80 years who have a 30 pack-year smoking history and currently smoke or have quit within the past 15 years. Screening should be discontinued once a person has not smoked for 15 years or develops a health problem that substantially limits life expectancy or the ability or willingness to have curative lung surgery. (Grade B)"

Cost-effectiveness

The cost per year of life save from smoking cessation[24][25] is less than the costs per year of life saved from screening for lung cancer with low-dose computed tomography[26][8].

References

  1. ↑ "Error in Results". JAMA Oncol. 5 (9): 1372. 2019. doi:10.1001/jamaoncol.2019.3296. PMC 6681549 Check |pmc= value (help). PMID 31369038.
  2. ↑ Liu Y, Pan IE, Tak HJ, Vlahos I, Volk R, Shih YT (2022). "Assessment of Uptake Appropriateness of Computed Tomography for Lung Cancer Screening According to Patients Meeting Eligibility Criteria of the US Preventive Services Task Force". JAMA Netw Open. 5 (11): e2243163. doi:10.1001/jamanetworkopen.2022.43163. PMC 9679877 Check |pmc= value (help). PMID 36409492 Check |pmid= value (help).
  3. ↑ Kane GC, Barta JA, Shusted CS, Evans NR (2022). "Now Is the Time to Make Screening for Lung Cancer Reportable". Ann Intern Med. 175 (6): 888–889. doi:10.7326/M22-0142. PMID 35404673 Check |pmid= value (help).
  4. ↑ "Lung Cancer: Screening". MRCH 9, 2021. Retrieved Sept 15,2022. Check date values in: |accessdate=, |date= (help)
  5. ↑ Screening for Lung Cancer with Low Dose Computed Tomography (LDCT). https://www.cms.gov/medicare-coverage-database/view/ncacal-decision-memo.aspx?proposed=N&ncaid=304
  6. ↑ 6.0 6.1 "http://www.uspreventiveservicestaskforce.org/uspstf13/lungcan/lungcanfinalrs.htm". Retrieved 31 December 2013. External link in |title= (help)
  7. ↑ de Koning HJ, Meza R, Plevritis SK, ten Haaf K, Munshi VN, Jeon J; et al. (2014). "Benefits and harms of computed tomography lung cancer screening strategies: a comparative modeling study for the U.S. Preventive Services Task Force". Ann Intern Med. 160 (5): 311–20. doi:10.7326/M13-2316. PMC 4116741. PMID 24379002.
  8. ↑ 8.0 8.1 Black WC, Gareen IF, Soneji SS, Sicks JD, Keeler EB, Aberle DR; et al. (2014). "Cost-effectiveness of CT screening in the National Lung Screening Trial". N Engl J Med. 371 (19): 1793–802. doi:10.1056/NEJMoa1312547. PMC 4335305. PMID 25372087. Review in: Evid Based Med. 2015 Apr;20(2):78
  9. ↑ Oken MM, Hocking WG, Kvale PA, Andriole GL, Buys SS, Church TR; et al. (2011). "Screening by chest radiograph and lung cancer mortality: the Prostate, Lung, Colorectal, and Ovarian (PLCO) randomized trial". JAMA. 306 (17): 1865–73. doi:10.1001/jama.2011.1591. PMID 22031728. Review in: Evid Based Med. 2012 Oct;17(5):149-50 Review in: Ann Intern Med. 2012 Mar 20;156(6):JC3-8
  10. ↑ Pastorino U, Rossi M, Rosato V, Marchianò A, Sverzellati N, Morosi C; et al. (2012). "Annual or biennial CT screening versus observation in heavy smokers: 5-year results of the MILD trial". Eur J Cancer Prev. 21 (3): 308–15. doi:10.1097/CEJ.0b013e328351e1b6. PMID 22465911.
  11. ↑ Detterbeck FC, Mazzone PJ, Naidich DP, Bach PB (2013). "Screening for Lung Cancer: Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines". Chest. 143 (5 Suppl): e78S–92S. doi:10.1378/chest.12-2350. PMID 23649455. Summary in JournalWatch
  12. ↑ Midthun, David E. (2016). "Early detection of lung cancer". F1000Research. 5: 739. doi:10.12688/f1000research.7313.1. ISSN 2046-1402.
  13. ↑ Midthun, David E. (2011). "Screening for Lung Cancer". Clinics in Chest Medicine. 32 (4): 659–668. doi:10.1016/j.ccm.2011.08.014. ISSN 0272-5231.
  14. ↑ U.S. Preventive Services Task Force (2004). "Lung cancer screening: recommendation statement". Ann. Intern. Med. 140 (9): 738–9. PMID 15126258.
  15. ↑ Humphrey LL, Teutsch S, Johnson M (2004). "Lung cancer screening with sputum cytologic examination, chest radiography, and computed tomography: an update for the U.S. Preventive Services Task Force". Ann. Intern. Med. 140 (9): 740–53. PMID 15126259.
  16. ↑ Alberts WM (2007). "Diagnosis and Management of Lung Cancer Executive Summary: ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition)". 132 (3_suppl): 1S–19S. doi:10.1378/chest.07-1860. PMID 17873156.
  17. ↑ Pulmonary nodule - probability of malignancy using Mayo Clinic model. Avalable at http://openrules.github.io/
  18. ↑ Manser RL, Irving LB, Stone C, Byrnes G, Abramson M, Campbell D (2004). "Screening for lung cancer". Cochrane database of systematic reviews (Online) (1): CD001991. doi:10.1002/14651858.CD001991.pub2. PMID 14973979.
  19. ↑ Henschke CI, Yip R, Yankelevitz DF, Smith JP, International Early Lung Cancer Action Program Investigators* (2013). "Definition of a positive test result in computed tomography screening for lung cancer: a cohort study". Ann Intern Med. 158 (4): 246–52. doi:10.7326/0003-4819-158-4-201302190-00004. PMID 23420233.
  20. ↑ Henschke CI, Yankelevitz DF, Libby DM, Pasmantier MW, Smith JP, Miettinen OS (2006). "Survival of patients with stage I lung cancer detected on CT screening". N. Engl. J. Med. 355 (17): 1763–71. doi:10.1056/NEJMoa060476. PMID 17065637.
  21. ↑ Bach PB, Jett JR, Pastorino U, Tockman MS, Swensen SJ, Begg CB (2007). "Computed tomography screening and lung cancer outcomes". JAMA. 297 (9): 953–61. doi:10.1001/jama.297.9.953. PMID 17341709.
  22. ↑ Aberle DR, DeMello S, Berg CD, Black WC, Brewer B, Church TR; et al. (2013). "Results of the two incidence screenings in the National Lung Screening Trial". N Engl J Med. 369 (10): 920–31. doi:10.1056/NEJMoa1208962. PMC 4307922. PMID 24004119.
  23. ↑ Infante M, Cavuto S, Lutman FR, Passera E, Chiarenza M, Chiesa G; et al. (2015). "Long-Term Follow-up Results of the DANTE Trial, a Randomized Study of Lung Cancer Screening with Spiral Computed Tomography". Am J Respir Crit Care Med. 191 (10): 1166–75. doi:10.1164/rccm.201408-1475OC. PMID 25760561.
  24. ↑ Cromwell J, Bartosch WJ, Fiore MC, Hasselblad V, Baker T (1997). "Cost-effectiveness of the clinical practice recommendations in the AHCPR guideline for smoking cessation. Agency for Health Care Policy and Research". JAMA. 278 (21): 1759–66. PMID 9388153.
  25. ↑ Kaper J, Wagena EJ, van Schayck CP, Severens JL (2006). "Encouraging smokers to quit: the cost effectiveness of reimbursing the costs of smoking cessation treatment". Pharmacoeconomics. 24 (5): 453–64. doi:10.2165/00019053-200624050-00004. PMID 16706571.
  26. ↑ Criss SD, Cao P, Bastani M, Ten Haaf K, Chen Y, Sheehan DF; et al. (2019). "Cost-Effectiveness Analysis of Lung Cancer Screening in the United States: A Comparative Modeling Study". Ann Intern Med. doi:10.7326/M19-0322. PMID 31683314.

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