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| [[Aortic stenosis resident survival guide|'''Resident'''<br>'''Survival'''<br>'''Guide''']]
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{{Aortic stenosis}}
{{Aortic stenosis}}
{{CMG}}; {{AOEIC}} [[User:Mohammed Sbeih|Mohammed A. Sbeih, M.D.]] [mailto:msbeih@wikidoc.org]; {{CZ}}; '''Assistant Editor-In-Chief:''' [[Kristin Feeney|Kristin Feeney, B.S.]] [mailto:kfeeney@elon.edu]
{{CMG}}; {{AOEIC}} {{Sara.Zand}} [[User:Mohammed Sbeih|Mohammed A. Sbeih, M.D.]] [mailto:msbeih@wikidoc.org]; {{CZ}}; {{USAMA}} '''Assistant Editor-In-Chief:''' [[Kristin Feeney|Kristin Feeney, B.S.]] [mailto:kfeeney@elon.edu]; {{Rim}}
 
{{SK}} AS; Aortic stenosis; AVR; Aortic valve replacement; TAVI; Transcatheter aortic valve implantation; ACEI; Angiotensin-converting enzyme inhibitor; CAD; Coronary artery disease; LV; Left ventricle
==Overview==
==Overview==
While medical therapy may improve the symptoms of patients with aortic stenosis, medical therapy does not prolong life expectancy.  [[Aortic valve replacement]] remains the definitive treatment of symptomatic aortic stenosis and it improves both the symptoms and life expectancy of patients with aortic stenosis. When pharmacological therapies are used, extreme caution must be taken in the administration of [[vasodilator]]s as excess vasodilation may lead to [[hypotension]], a reduction in perfusion pressure to the heart, a further decline in [[cardiac output]] and further hypotension. This downward spiral can be fatal and must be avoided at all costs.
Medical treatment of [[hypertension]] and [[hyperlipidemia]] according to the Guidelines is considered for [[patients]] with [[AS]]. Therapy with [[ACE inhibitor]] or [[ARB]]   may reduce the [[mortality rate]] in [[patients]] with [[AS]] who underwent [[TAVI]].


===Pharmacotherpay===
==Medical Therapy==
* [[Hypertension]] is common in [[patients]] with [[AS]], may be a risk factor for [[AS]], and increases the total [[pressure overload]] on the [[left ventricle]] in combination with [[valve]] obstruction.<ref name="pmid31290937">{{cite journal |vauthors=Nazarzadeh M, Pinho-Gomes AC, Smith Byrne K, Canoy D, Raimondi F, Ayala Solares JR, Otto CM, Rahimi K |title=Systolic Blood Pressure and Risk of Valvular Heart Disease: A Mendelian Randomization Study |journal=JAMA Cardiol |volume=4 |issue=8 |pages=788–795 |date=August 2019 |pmid=31290937 |pmc=6624812 |doi=10.1001/jamacardio.2019.2202 |url=}}</ref><ref name="pmid27486164">{{cite journal |vauthors=Nielsen OW, Sajadieh A, Sabbah M, Greve AM, Olsen MH, Boman K, Nienaber CA, Kesäniemi YA, Pedersen TR, Willenheimer R, Wachtell K |title=Assessing Optimal Blood Pressure in Patients With Asymptomatic Aortic Valve Stenosis: The Simvastatin Ezetimibe in Aortic Stenosis Study (SEAS) |journal=Circulation |volume=134 |issue=6 |pages=455–68 |date=August 2016 |pmid=27486164 |doi=10.1161/CIRCULATIONAHA.115.021213 |url=}}</ref><ref name="pmid16022957">{{cite journal |vauthors=Briand M, Dumesnil JG, Kadem L, Tongue AG, Rieu R, Garcia D, Pibarot P |title=Reduced systemic arterial compliance impacts significantly on left ventricular afterload and function in aortic stenosis: implications for diagnosis and treatment |journal=J Am Coll Cardiol |volume=46 |issue=2 |pages=291–8 |date=July 2005 |pmid=16022957 |doi=10.1016/j.jacc.2004.10.081 |url=}}</ref>
* 2 small [[RCTs]] have not confirmed that [[antihypertensive]] [[ medications]] may reduce the [[cardiac output]] because [[AS]] does not result in fixed [[valve]] obstruction until late stage of the [[disease]].
* The study of asymptomatic [[AS]] showed the association of [[hypertension]] with higher rate of [[ischemic cardiovascular]] events and a 2-fold higher [[mortality rate]] than  normotensive [[patients]] with [[AS]]. However, impact on progression of valve stenosis leading to [[symptoms]] requiring [[AVR]] was not observed.
* [[Medical therapy]] for [[hypertension]] is based on the standard guidelines, initiating at a low dose and gradually titrated upward as needed to controlling of [[blood pressure]].
* There are no studies considering specific [[antihypertensive]] medications in [[patients]] with [[AS]], but [[diuretics]] may reduce [[stroke volume]], particularly if the [[LV]] chamber is small at baseline.
* The advantages of [[ACE inhibitors]] include beneficial effects on [[LV fibrosis]], and control of [[hypertension]].<ref name="pmid15222408">{{cite journal |vauthors=O'Brien KD, Zhao XQ, Shavelle DM, Caulfield MT, Letterer RA, Kapadia SR, Probstfield JL, Otto CM |title=Hemodynamic effects of the angiotensin-converting enzyme inhibitor, ramipril, in patients with mild to moderate aortic stenosis and preserved left ventricular function |journal=J Investig Med |volume=52 |issue=3 |pages=185–91 |date=April 2004 |pmid=15222408 |doi=10.1136/jim-52-03-33 |url=}}</ref>
* Target [[blood pressure]] should be considered higher for [[patients]] with [[AS]]  than is recommended for the general [[population]].
*Concurrent [[coronary artery disease]] is common in [[patients]] with [[AS]],  and screening of all [[patients]] is recommended for [[hypercholesterolemia]], for primary and [[secondary prevention]] of [[CAD]].
* In [[RCTs]] of [[statin]] therapy for mild to [[moderate AS]], the rate of [[ischemic]] events was reduced by about 20% in the [[statin]] therapy group. Howerer, [[aortic valve]] event rates were not reduced.<ref name="pmid18765433">{{cite journal |vauthors=Rossebø AB, Pedersen TR, Boman K, Brudi P, Chambers JB, Egstrup K, Gerdts E, Gohlke-Bärwolf C, Holme I, Kesäniemi YA, Malbecq W, Nienaber CA, Ray S, Skjaerpe T, Wachtell K, Willenheimer R |title=Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis |journal=N Engl J Med |volume=359 |issue=13 |pages=1343–56 |date=September 2008 |pmid=18765433 |doi=10.1056/NEJMoa0804602 |url=}}</ref><ref name="pmid20048204">{{cite journal |vauthors=Chan KL, Teo K, Dumesnil JG, Ni A, Tam J |title=Effect of Lipid lowering with rosuvastatin on progression of aortic stenosis: results of the aortic stenosis progression observation: measuring effects of rosuvastatin (ASTRONOMER) trial |journal=Circulation |volume=121 |issue=2 |pages=306–14 |date=January 2010 |pmid=20048204 |doi=10.1161/CIRCULATIONAHA.109.900027 |url=}}</ref><ref name="pmid17276178">{{cite journal |vauthors=Moura LM, Ramos SF, Zamorano JL, Barros IM, Azevedo LF, Rocha-Gonçalves F, Rajamannan NM |title=Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis |journal=J Am Coll Cardiol |volume=49 |issue=5 |pages=554–61 |date=February 2007 |pmid=17276178 |pmc=3951859 |doi=10.1016/j.jacc.2006.07.072 |url=}}</ref>
*In [[patients]] undergoing [[TAVI]], treatment  with [[renin–angiotensin system]] blocker therapy after the procedure had a lower 1-year [[mortality rate]] than those not treated with [[renin–angiotensin system blocker therapy]], with a relative risk reduction of about 20% to 50% and an [[absolute risk reduction]] between 2.4% and 5.0%.
* Use of [[renin–angiotensin system inhibitor]], was associated with a lower 1-year [[mortality rate]] among [[patients]] with [[preserved LVEF]] but not among those with [[reduced LVEF]].<ref name="pmid28986405">{{cite journal |vauthors=Ochiai T, Saito S, Yamanaka F, Shishido K, Tanaka Y, Yamabe T, Shirai S, Tada N, Araki M, Naganuma T, Watanabe Y, Yamamoto M, Hayashida K |title=Renin-angiotensin system blockade therapy after transcatheter aortic valve implantation |journal=Heart |volume=104 |issue=8 |pages=644–651 |date=April 2018 |pmid=28986405 |doi=10.1136/heartjnl-2017-311738 |url=}}</ref><ref name="pmid28956773">{{cite journal |vauthors=Hansson NH, Sörensen J, Harms HJ, Kim WY, Nielsen R, Tolbod LP, Frøkiær J, Bouchelouche K, Dodt KK, Sihm I, Poulsen SH, Wiggers H |title=Metoprolol Reduces Hemodynamic and Metabolic Overload in Asymptomatic Aortic Valve Stenosis Patients: A Randomized Trial |journal=Circ Cardiovasc Imaging |volume=10 |issue=10 |pages= |date=October 2017 |pmid=28956773 |doi=10.1161/CIRCIMAGING.117.006557 |url=}}</ref><ref name="pmid30512100">{{cite journal |vauthors=Inohara T, Manandhar P, Kosinski AS, Matsouaka RA, Kohsaka S, Mentz RJ, Thourani VH, Carroll JD, Kirtane AJ, Bavaria JE, Cohen DJ, Kiefer TL, Gaca JG, Kapadia SR, Peterson ED, Vemulapalli S |title=Association of Renin-Angiotensin Inhibitor Treatment With Mortality and Heart Failure Readmission in Patients With Transcatheter Aortic Valve Replacement |journal=JAMA |volume=320 |issue=21 |pages=2231–2241 |date=December 2018 |pmid=30512100 |pmc=6583475 |doi=10.1001/jama.2018.18077 |url=}}</ref>
* 3 large well-designed [[RCTs]] failed to show a benefit of [[statins]]  for prevention of progression of [[AS]] in terms of [[hemodynamic severity]] or clinical outcomes.


====Lipid-Lowering====
{| style="cellpadding=0; cellspacing= 0; width: 800px;"
More rapid progression of aortic stenosis has been associated with traditional risk factors for atherosclerosis. Based on the similarities that exist between [[calcific aortic stenosis]] and [[atherosclerosis]] in terms of their pathological features and risk factors, there has been a substantial interest to modify the progression of calcific aortic stenosis with the administration of cholesterol lowering agents such as [[statins]]. A number of small, [[observational studies]] have demonstrated an association between low cholesterol levels and decreased progression of aortic stenosis, and even regression of calcific aortic stenosis.  Administration of [[rosuvastatin]] has been associated with a slowing of aortic stenosis progression in a small study<ref>{{cite journal |author=Moura LM, Ramos SF, Zamorano JL, ''et al'' |title=Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis |journal=J. Am. Coll. Cardiol. |volume=49 |issue=5 |pages=554-61 |year=2007 |pmid=17276178 |doi=10.1016/j.jacc.2006.07.072}}</ref>.
|-
 
| style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF;" align=center |'''Recommendations for medical therapy in aortic stenosis'''
====Vasodilators====
''Extreme care should be taken to avoid excess vasodilation in the patient with critical aortic stenosis which could precipitate a downward spiral of low forward output, impaired subendocardial perfusion, [[ischemia]] and further reduction in forward output.''
 
[[Nitroglycerin]] is helpful in relieving [[angina pectoris]] symptoms but should be used cautiously to avoid [[hypotention]] and excess vasodilation.
 
====Diuretics====
[[Diuretics]] should be administered cautiously to avoid [[dehydration]], [[hypovolemia]] and a significant reduction in [[cardiac output]].


====Other Therapies====
[[Beta blockers]] and [[angiotensin-converting enzyme inhibitors]] are generally safe for asymptomatic patients with preserved left ventricular systolic function.
====Sodium Restriction====
If the patient has symptoms of [[heart failure]], the patient should be placed on sodium restriction.
==ACC/AHA 2008 Guidelines for the Management of Adults with Congenital Heart Disease (DO NOT EDIT)<ref name="pmid19038677">{{cite journal |author=Warnes CA, Williams RG, Bashore TM, Child JS, Connolly HM, Dearani JA, del Nido P, Fasules JW, Graham TP, Hijazi ZM, Hunt SA, King ME, Landzberg MJ, Miner PD, Radford MJ, Walsh EP, Webb GD, Smith SC, Jacobs AK, Adams CD, Anderson JL, Antman EM, Buller CE, Creager MA, Ettinger SM, Halperin JL, Hunt SA, Krumholz HM, Kushner FG, Lytle BW, Nishimura RA, Page RL, Riegel B, Tarkington LG, Yancy CW |title=ACC/AHA 2008 guidelines for the management of adults with congenital heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Develop Guidelines on the Management of Adults With Congenital Heart Disease). Developed in Collaboration With the American Society of Echocardiography, Heart Rhythm Society, International Society for Adult Congenital Heart Disease, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons |journal=[[Journal of the American College of Cardiology]] |volume=52 |issue=23 |pages=e143–263 |year=2008 |month=December |pmid=19038677 |doi=10.1016/j.jacc.2008.10.001 |url=http://linkinghub.elsevier.com/retrieve/pii/S0735-1097(08)03304-4 |accessdate=2013-01-09}}</ref>==
{|class="wikitable"
|-
|-
| colspan="1" style="text-align:center; background:LemonChiffon"|[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class IIa]]
|style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left | '''  ([[ AHA guidelines classification scheme|Class I, Level of Evidence B]]):'''
|-
|-
| bgcolor="LemonChiffon"|<nowiki>"</nowiki>'''1.''' It is reasonable to treat systemic [[hypertension]] in patients with AS while monitoring [[diastolic blood pressure]] to avoid reducing coronary perfusion.'' ([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: C]])''<nowiki>"</nowiki>
|style="padding: 0 5px; font-size: 100%; background: #F5F5F5; width: 70%" align=left|
❑ In [[patients]] at risk of developing [[AS]] (stage A) or asymptomatic [[AS]] (stage B,C), [[hypertension]] should be controlled by initiating low dose medications and titration doses based on [[clinical ]] evaluation<br>
|-
|-
| bgcolor="LemonChiffon"|<nowiki>"</nowiki>'''2.''' It is reasonable to administer beta blockers in patients with BAV and aortic root dilatation.'' ([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: C]])''<nowiki>"</nowiki>
|style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left | ''' ([[ AHA guidelines classification scheme|Class I, Level of Evidence A]]):'''
|-
|-
| bgcolor="LemonChiffon"|<nowiki>"</nowiki>'''3.''' It is reasonable to use long-term [[vasodilator]] therapy in patients with AR and systemic hypertension while carefully monitoring diastolic blood pressure to avoid reducing coronary perfusion.'' ([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: C]])''<nowiki>"</nowiki>
|style="padding: 0 5px; font-size: 100%; background: #F5F5F5; width: 70%" align=left|
|}
❑[[Statin]] therapy is recommended in all [[patients]] with calcified [[AS]] for primary and [[secondary prevention]] of [[atherosclerosis]]


{|class="wikitable"
|-
|-
| colspan="1" style="text-align:center; background:LemonChiffon"|[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class IIb]]
|style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left | '''  ([[ AHA guidelines classification scheme|Class IIb, Level of Evidence B]]):'''
|-
|-
| bgcolor="LemonChiffon"|<nowiki>"</nowiki>'''1.''' It may be reasonable to treat patients with BAV and risk factors for [[atherosclerosis]] with [[statin]]s with the aim of ‘‘slowing down degenerative changes in the [[aortic valve]] and preventing atherosclerosis.'' ([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: C]])''<nowiki>"</nowiki>
|style="padding: 0 5px; font-size: 100%; background: #F5F5F5; width: 70%" align=left|
❑[[ACEI]] or [[ARB]] may be considered after [[TAVI]] to reduce the long term risk of [[all cause mortality]]
|-
|style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left | ''' NO benefit([[ AHA guidelines classification scheme|Class III, Level of Evidence A]]):'''
|-
|style="padding: 0 5px; font-size: 100%; background: #F5F5F5; width: 70%" align=left|
❑[[Statin]] is not indicated in [[calcified]] [[AS]] (stage B,C) for prevention of [[hemodynamic]] progression of [[AS]]
|}
{|
! colspan="2" style="background: PapayaWhip;" align="center" + |The above table adopted from 2020 AHA-ACC Guideline<ref name="pmid33332150">{{cite journal |vauthors=Otto CM, Nishimura RA, Bonow RO, Carabello BA, Erwin JP, Gentile F, Jneid H, Krieger EV, Mack M, McLeod C, O'Gara PT, Rigolin VH, Sundt TM, Thompson A, Toly C |title=2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines |journal=Circulation |volume=143 |issue=5 |pages=e72–e227 |date=February 2021 |pmid=33332150 |doi=10.1161/CIR.0000000000000923 |url=}}</ref>
|-
|}
|}




==AHA/ACC 2014 Guideline for the Management of Patients With Valvular Heart Diseases <ref>{{Cite web  | last =  | first =  | title = 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary | url = http://circ.ahajournals.org/content/early/2014/02/27/CIR.0000000000000029.full.pdf+html | publisher =  | date =  | accessdate = 4 March 2014 }}</ref>==
<span style="font-size:85%">'''Abbreviations:'''
'''[[AS]]:''' [[ Aortic stenosis]];
'''[[TAVI]]:''' [[Transcatheter aortic valve implantation]];


{|class="wikitable"
</span>
|-
<br>
| colspan="1" style="text-align:center; background:LightGreen"|[[EHS ESC guidelines classification scheme#Classification of Recommendations|Class I]]
|-
| bgcolor="LightGreen"|<nowiki>"</nowiki>'''1. '''[[Hypertension]] in patients at risk for developing [[AS]] (stage A) and in patients with asymptomatic AS (stages B and C) should be treated according to standard GDMT, started at a low dose, and  gradually titrated upward as needed with frequent clinical monitoring. (Level of Evidence:B) ''<nowiki>"</nowiki>
|}
{|class="wikitable"
|-
| colspan="1" style="text-align:center; background:LemonChiffon"|[[EHS ESC guidelines classification scheme#Classification of Recommendations|Class IIb]]
|-
| bgcolor="LemonChiffon"|<nowiki>"</nowiki>'''1. '''[[Vasodilator]] therapy may be reasonable if used with invasive hemodynamic monitoring in the acute management of patients with severe decompensated [[AS]] (stage D) with New York Heart Association ([[NYHA]]) class IV [[heart failure]] symptoms. (Level of Evidence: C)''<nowiki>"</nowiki>
|}
{|class="wikitable"
|-
| colspan="1" style="text-align:center; background:LightCoral"|[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class III]]
|-
| bgcolor="LightCoral"|<nowiki>"</nowiki>'''1.''' [[Statin]] therapy is not indicated for prevention of hemodynamic progression of [[AS]] in patients with mild-to-moderate calcific valve disease (stages B to D) (54-56). (Level of Evidence: A) ''<nowiki>"</nowiki>
|}


==References==
==References==
{{reflist|2}}
{{reflist|2}}
{{WH}}
{{WS}}
[[CME Category::Cardiology]]


[[Category:Disease]]
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[[Category:Surgery]]
[[Category:Surgery]]
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Latest revision as of 07:43, 26 July 2022
Resident
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Sara Zand, M.D.[2] Mohammed A. Sbeih, M.D. [3]; Cafer Zorkun, M.D., Ph.D. [4]; Usama Talib, BSc, MD [5] Assistant Editor-In-Chief: Kristin Feeney, B.S. [6]; Rim Halaby, M.D. [7] Synonyms and keywords: AS; Aortic stenosis; AVR; Aortic valve replacement; TAVI; Transcatheter aortic valve implantation; ACEI; Angiotensin-converting enzyme inhibitor; CAD; Coronary artery disease; LV; Left ventricle

Overview

Medical treatment of hypertension and hyperlipidemia according to the Guidelines is considered for patients with AS. Therapy with ACE inhibitor or ARB may reduce the mortality rate in patients with AS who underwent TAVI.

Medical Therapy

Recommendations for medical therapy in aortic stenosis
(Class I, Level of Evidence B):

❑ In patients at risk of developing AS (stage A) or asymptomatic AS (stage B,C), hypertension should be controlled by initiating low dose medications and titration doses based on clinical evaluation

(Class I, Level of Evidence A):

❑Statin therapy is recommended in all patients with calcified AS for primary and secondary prevention of atherosclerosis

(Class IIb, Level of Evidence B):

❑ACEI or ARB may be considered after TAVI to reduce the long term risk of all cause mortality

NO benefit(Class III, Level of Evidence A):

❑Statin is not indicated in calcified AS (stage B,C) for prevention of hemodynamic progression of AS

The above table adopted from 2020 AHA-ACC Guideline[11]


Abbreviations: AS: Aortic stenosis; TAVI: Transcatheter aortic valve implantation;


References

  1. ↑ Nazarzadeh M, Pinho-Gomes AC, Smith Byrne K, Canoy D, Raimondi F, Ayala Solares JR, Otto CM, Rahimi K (August 2019). "Systolic Blood Pressure and Risk of Valvular Heart Disease: A Mendelian Randomization Study". JAMA Cardiol. 4 (8): 788–795. doi:10.1001/jamacardio.2019.2202. PMC 6624812 Check |pmc= value (help). PMID 31290937.
  2. ↑ Nielsen OW, Sajadieh A, Sabbah M, Greve AM, Olsen MH, Boman K, Nienaber CA, Kesäniemi YA, Pedersen TR, Willenheimer R, Wachtell K (August 2016). "Assessing Optimal Blood Pressure in Patients With Asymptomatic Aortic Valve Stenosis: The Simvastatin Ezetimibe in Aortic Stenosis Study (SEAS)". Circulation. 134 (6): 455–68. doi:10.1161/CIRCULATIONAHA.115.021213. PMID 27486164.
  3. ↑ Briand M, Dumesnil JG, Kadem L, Tongue AG, Rieu R, Garcia D, Pibarot P (July 2005). "Reduced systemic arterial compliance impacts significantly on left ventricular afterload and function in aortic stenosis: implications for diagnosis and treatment". J Am Coll Cardiol. 46 (2): 291–8. doi:10.1016/j.jacc.2004.10.081. PMID 16022957.
  4. ↑ O'Brien KD, Zhao XQ, Shavelle DM, Caulfield MT, Letterer RA, Kapadia SR, Probstfield JL, Otto CM (April 2004). "Hemodynamic effects of the angiotensin-converting enzyme inhibitor, ramipril, in patients with mild to moderate aortic stenosis and preserved left ventricular function". J Investig Med. 52 (3): 185–91. doi:10.1136/jim-52-03-33. PMID 15222408.
  5. ↑ Rossebø AB, Pedersen TR, Boman K, Brudi P, Chambers JB, Egstrup K, Gerdts E, Gohlke-Bärwolf C, Holme I, Kesäniemi YA, Malbecq W, Nienaber CA, Ray S, Skjaerpe T, Wachtell K, Willenheimer R (September 2008). "Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis". N Engl J Med. 359 (13): 1343–56. doi:10.1056/NEJMoa0804602. PMID 18765433.
  6. ↑ Chan KL, Teo K, Dumesnil JG, Ni A, Tam J (January 2010). "Effect of Lipid lowering with rosuvastatin on progression of aortic stenosis: results of the aortic stenosis progression observation: measuring effects of rosuvastatin (ASTRONOMER) trial". Circulation. 121 (2): 306–14. doi:10.1161/CIRCULATIONAHA.109.900027. PMID 20048204.
  7. ↑ Moura LM, Ramos SF, Zamorano JL, Barros IM, Azevedo LF, Rocha-Gonçalves F, Rajamannan NM (February 2007). "Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis". J Am Coll Cardiol. 49 (5): 554–61. doi:10.1016/j.jacc.2006.07.072. PMC 3951859. PMID 17276178.
  8. ↑ Ochiai T, Saito S, Yamanaka F, Shishido K, Tanaka Y, Yamabe T, Shirai S, Tada N, Araki M, Naganuma T, Watanabe Y, Yamamoto M, Hayashida K (April 2018). "Renin-angiotensin system blockade therapy after transcatheter aortic valve implantation". Heart. 104 (8): 644–651. doi:10.1136/heartjnl-2017-311738. PMID 28986405.
  9. ↑ Hansson NH, Sörensen J, Harms HJ, Kim WY, Nielsen R, Tolbod LP, Frøkiær J, Bouchelouche K, Dodt KK, Sihm I, Poulsen SH, Wiggers H (October 2017). "Metoprolol Reduces Hemodynamic and Metabolic Overload in Asymptomatic Aortic Valve Stenosis Patients: A Randomized Trial". Circ Cardiovasc Imaging. 10 (10). doi:10.1161/CIRCIMAGING.117.006557. PMID 28956773.
  10. ↑ Inohara T, Manandhar P, Kosinski AS, Matsouaka RA, Kohsaka S, Mentz RJ, Thourani VH, Carroll JD, Kirtane AJ, Bavaria JE, Cohen DJ, Kiefer TL, Gaca JG, Kapadia SR, Peterson ED, Vemulapalli S (December 2018). "Association of Renin-Angiotensin Inhibitor Treatment With Mortality and Heart Failure Readmission in Patients With Transcatheter Aortic Valve Replacement". JAMA. 320 (21): 2231–2241. doi:10.1001/jama.2018.18077. PMC 6583475 Check |pmc= value (help). PMID 30512100.
  11. ↑ Otto CM, Nishimura RA, Bonow RO, Carabello BA, Erwin JP, Gentile F, Jneid H, Krieger EV, Mack M, McLeod C, O'Gara PT, Rigolin VH, Sundt TM, Thompson A, Toly C (February 2021). "2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines". Circulation. 143 (5): e72–e227. doi:10.1161/CIR.0000000000000923. PMID 33332150 Check |pmid= value (help).

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