Group B streptococcal infection laboratory tests: Difference between revisions
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|style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |'''Infants with signs of sepsis''' || style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |'''Complete diagnostic evaluation''' (class A, level of evidence II)<br> | |style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |'''Infants with signs of sepsis''' || style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |'''Complete diagnostic evaluation''' (class A, level of evidence II)<br> | ||
* [[CBC]] including [[white blood cell]] differential and [[platelet count]] | * [[CBC]] including [[white blood cell]] differential and [[platelet count]] | ||
* [[Blood culture]] | * [[Blood culture]] | ||
* [[Chest radiograph]] | * [[Chest radiograph]] | ||
* [[Lumbar puncture]] | * [[Lumbar puncture]] | ||
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==Laboratory Findings== | |||
The diagnosis of GBS infection is confirmed by the isolation of the organism in either the [[blood]] or [[CSF]]. Blood cultures can be sterile in as many as 15% to 33% of newborns with meningitis.<ref name=CDCMMWR>Verani J.R., McGee L, and Schrag S.J. Prevention of Perinatal Group B Streptococcal Disease. Revised Guidelines from CDC, 2010.[http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5910a1.htm?s_cid=rr5910a1_w CDC.gov]</ref> | |||
Other laboratory findings that are indicative of an infection but non-specific to GBS include elevated [[WBC]] and abnormal findings in the [[CSF]] analysis. | |||
==References== | ==References== | ||
Revision as of 19:54, 20 August 2014
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Group B Streptococcal Infection Microchapters |
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Differentiating Group B Streptococcal Infection from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]
Overview
Laboratory Tests
Shown below is a table that summarizes the laboratory tests that are recommended in different scenarios of possible GBS infection in neonates.[1]
| Scenario | Recommended Diagnostic Evaluation |
| Infants with signs of sepsis | Complete diagnostic evaluation (class A, level of evidence II)
|
| Infants born to women with chorioamnionitis | Limited diagnostic evaluation (class A, level of evidence II)
|
| Well-appearing infants PLUS The mother had no chorioamnionitis and no indication for GBS prophylaxis |
No routine diagnostic testing |
| Well-appearing infants PLUS The mother received adequate intrapartum GBS prophylaxis |
No routine diagnostic testing (class B, level of evidence III) |
| Well-appearing infants PLUS The mother had an indication for GBS prophylaxis but received no or inadequate prophylaxis PLUS The infant is well-appearing PLUS ≥37 weeks and 0 days' gestational age PLUS The duration of membrane rupture before delivery was <18 hours |
No routine diagnostic testing (class B, level of evidence III) |
| Well-appearing infants PLUS Either <37 weeks and 0 days' gestational age OR The duration of membrane rupture before delivery was ≥18 hours |
Limited diagnostic evaluation (class B, level of evidence III)
|
Laboratory Findings
The diagnosis of GBS infection is confirmed by the isolation of the organism in either the blood or CSF. Blood cultures can be sterile in as many as 15% to 33% of newborns with meningitis.[1]
Other laboratory findings that are indicative of an infection but non-specific to GBS include elevated WBC and abnormal findings in the CSF analysis.