Sideroblastic anemia causes: Difference between revisions
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{{Sideroblastic anemia}} | {{Sideroblastic anemia}} | ||
{{CMG}} | {{CMG}} | ||
==Overview== | |||
==Causes== | ==Causes== | ||
The common feature of these causes is a failure to completely form [[heme]] - whose biosynthesis takes place partly in the [[mitochondrion]]. This leads to deposits of iron in the [[mitochondria]] that form a ring around the [[Cell nucleus|nucleus]] of the developing [[red blood cell]]. Sometimes the disorder represents a stage in evolution of a generalized bone marrow disorder that may ultimately terminate in acute leukemia. | The common feature of these causes is a failure to completely form [[heme]] - whose biosynthesis takes place partly in the [[mitochondrion]]. This leads to deposits of iron in the [[mitochondria]] that form a ring around the [[Cell nucleus|nucleus]] of the developing [[red blood cell]]. Sometimes the disorder represents a stage in evolution of a generalized bone marrow disorder that may ultimately terminate in acute leukemia. | ||
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{{WS}} | {{WS}} | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
Revision as of 16:11, 24 June 2016
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Sideroblastic anemia Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Sideroblastic anemia causes On the Web |
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American Roentgen Ray Society Images of Sideroblastic anemia causes |
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Risk calculators and risk factors for Sideroblastic anemia causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
The common feature of these causes is a failure to completely form heme - whose biosynthesis takes place partly in the mitochondrion. This leads to deposits of iron in the mitochondria that form a ring around the nucleus of the developing red blood cell. Sometimes the disorder represents a stage in evolution of a generalized bone marrow disorder that may ultimately terminate in acute leukemia.
- Toxins: lead or zinc poisoning
- Drug-induced: Cycloserine, ethanol, isoniazid, chloramphenicol, cycloserine, Penicillamine
- Nutritional: pyridoxine or copper deficiency
- Genetic: ALA synthase deficiency (X-linked)