Myeloproliferative neoplasm laboratory findings: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Myeloproliferative disease}} | {{Myeloproliferative disease}} | ||
{{CMG}} {{AE}} {{MJK}} | |||
==Overview== | |||
Laboratory findings consistent with the diagnosis of myeloproliferative neoplasm include [[leukocytosis]], [[thrombocytopenia]], and [[anemia]]. | |||
==Laboratory Findings== | |||
Laboratory findings associated with chronic myelogenous leukemia include:<ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab</ref> | |||
<ref>{{Cite journal | |||
| author = [[James W. Vardiman]] | |||
| title = Chronic myelogenous leukemia, BCR-ABL1+ | |||
| journal = [[American journal of clinical pathology]] | |||
| volume = 132 | |||
| issue = 2 | |||
| pages = 250–260 | |||
| year = 2009 | |||
| month = August | |||
| doi = 10.1309/AJCPUN89CXERVOVH | |||
| pmid = 19605820 | |||
}}</ref>*[[Complete blood count]] | |||
:*Increased [[granulocyte]]s of all types | |||
:*Increased [[basophil]]s and [[eosinophil]]s | |||
:*[[Thrombocytopenia]] | |||
:*[[Anemia]] | |||
*Blood chemistry | |||
:*The following blood levels may be elevated: | |||
::*Blood urea nitrogen ([[BUN]]) | |||
::*[[Creatinine]] | |||
::*[[Phosphate]] | |||
::*[[Lactate dehydrogenase]] (LDH) | |||
::*[[Alanine aminotransferase]] (ALT) | |||
::*[[Aspartate transaminase]] (AST) | |||
::*[[Uric acid]] | |||
*Bleeding and clotting factor | |||
:*The following blood levels may be elevated: | |||
::*[[Prothrombin time]] (PT) or [[international normalized ratio]] (INR) | |||
::*[[Partial thromboplastin time]] (PTT) | |||
*[[Cytochemistry]] | |||
:*Cytochemistry helps determine the type of cells that are present | |||
*[[Flow cytometry]] | |||
:* Flow cytometry helps determine the type of cells that are present | |||
*[[Cytogenetics]] | |||
:*Chromosome changes that may occur in some people with leukemia include: | |||
::*[[Translocations]] | |||
::*Inversions | |||
::*loss or gain of a chromosome number | |||
*Fluorescent in situ hybridization (FISH) | |||
:*Similar to cytogenetics, but more specific | |||
*Polymerase chain reaction | |||
:*Helpful to detect specific abnormalities in blood or bone marrow cells. Abnormalities can be found even if very few leukemia cells are present in a tissue sample. | |||
* Red cell mass determination (for polycythaemia) | * Red cell mass determination (for polycythaemia) | ||
Revision as of 13:35, 26 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
Laboratory findings consistent with the diagnosis of myeloproliferative neoplasm include leukocytosis, thrombocytopenia, and anemia.
Laboratory Findings
Laboratory findings associated with chronic myelogenous leukemia include:[1] [2]*Complete blood count
- Increased granulocytes of all types
- Increased basophils and eosinophils
- Thrombocytopenia
- Anemia
- Blood chemistry
- The following blood levels may be elevated:
- Blood urea nitrogen (BUN)
- Creatinine
- Phosphate
- Lactate dehydrogenase (LDH)
- Alanine aminotransferase (ALT)
- Aspartate transaminase (AST)
- Uric acid
- Bleeding and clotting factor
- The following blood levels may be elevated:
- Prothrombin time (PT) or international normalized ratio (INR)
- Partial thromboplastin time (PTT)
- Cytochemistry helps determine the type of cells that are present
- Flow cytometry helps determine the type of cells that are present
- Chromosome changes that may occur in some people with leukemia include:
- Translocations
- Inversions
- loss or gain of a chromosome number
- Fluorescent in situ hybridization (FISH)
- Similar to cytogenetics, but more specific
- Polymerase chain reaction
- Helpful to detect specific abnormalities in blood or bone marrow cells. Abnormalities can be found even if very few leukemia cells are present in a tissue sample.
- Red cell mass determination (for polycythaemia)
- Neutrophil alkaline phosphatase level
- Vitamin B12 (or B12 binding capacity)
- Serum urate.[3]
References
- ↑ Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab
- ↑ James W. Vardiman (2009). "Chronic myelogenous leukemia, BCR-ABL1+". American journal of clinical pathology. 132 (2): 250–260. doi:10.1309/AJCPUN89CXERVOVH. PMID 19605820. Unknown parameter
|month=ignored (help) - ↑ Levene, Malcolm I.; Lewis, S. M.; Bain, Barbara J.; Imelda Bates. Dacie & Lewis Practical Haematology. London: W B Saunders. p. 586. ISBN 0-443-06377-X.