Minimal change disease differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, Serge Korjian

Overview

The differential diagnosis of minimal change disease must always include other renal etiologies of nephrotic syndrome, such as focal segmental glomerulosclerosis (FSGS) and IgM nephropathy, and causes of peripheral edema and hypoalbuminemia, such as congestive heart failure, liver cirrhosis, and protein-losing enteropathy.

Differential Diagnosis

• Focal segmental glomerulosclerosis (FSGS)
• IgM nephropathy
• C1q nephropathy
• IgG nephropathy
• C3 mesangial nephropathy
• Membranoproliferative glomerulonephritis
• Congestive heart failure
• Liver cirrhosis
• Protein-losing enteropathy
• Kwashiorkor