Mepyramine: Difference between revisions
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'''Mepyramine''', also known as '''pyrilamine''', is a [[Antihistamine#H1-receptor antagonists|first generation antihistamine]], targeting the [[Histamine H1 receptor|H<sub>1</sub> receptor]].<ref>{{cite journal | last1 = Parsons | first1 = Mike E. | last2 = Ganellin |first2 = C. Robin | title = Histamine and its receptors | journal = British Journal of Pharmacology | volume = 147 | pages = S127–S135 |date=January 2006 | pmid = 16402096 | doi = 10.1038/sj.bjp.0706440 | pmc = 1760721 | issue = S1}}</ref> However, it rapidly permeates the brain often causing [[drowsiness]]. It also has [[anticholinergic]] properties. It is used in over-the-counter combination products to treat the common cold and menstrual symptoms.<ref>[http://midol.com/menstrual_complete_caps.html#q1 Active Ingredients for Midol Complete]</ref> It is also the active ingredient of the topical antihistamine creams ''Anthisan'' and ''Neoantergan'', sold for the treatment of insect bites, stings, and nettle rash. | '''Mepyramine''', also known as '''pyrilamine''', is a [[Antihistamine#H1-receptor antagonists|first generation antihistamine]], targeting the [[Histamine H1 receptor|H<sub>1</sub> receptor]].<ref>{{cite journal | last1 = Parsons | first1 = Mike E. | last2 = Ganellin |first2 = C. Robin | title = Histamine and its receptors | journal = British Journal of Pharmacology | volume = 147 | pages = S127–S135 |date=January 2006 | pmid = 16402096 | doi = 10.1038/sj.bjp.0706440 | pmc = 1760721 | issue = S1}}</ref> However, it rapidly permeates the brain often causing [[drowsiness]]. It also has [[anticholinergic]] properties. It is used in over-the-counter combination products to treat the common cold and menstrual symptoms.<ref>[http://midol.com/menstrual_complete_caps.html#q1 Active Ingredients for Midol Complete]</ref> It is also the active ingredient of the topical antihistamine creams ''Anthisan'' and ''Neoantergan'', sold for the treatment of insect bites, stings, and nettle rash. | ||
==Synthesis== | ==Synthesis== | ||
[[File:Pyrilamine synthesis.png|thumb|center|700px|Pyrilamine synthesis:<ref>R.J. Horclois, {{US Patent|2502151}} (1950).</ref><ref>{{Cite doi|10.1021/ja01214a037}}</ref><ref>D. Bovet, R. Horclois, F. Walthert, C.R. Soc. Biol., 138, 99 (1944).</ref>]] | [[File:Pyrilamine synthesis.png |thumb|center|700px|Pyrilamine synthesis:<ref>R.J. Horclois, {{US Patent|2502151}} (1950).</ref><ref>{{Cite doi|10.1021/ja01214a037}}</ref><ref>D. Bovet, R. Horclois, F. Walthert, C.R. Soc. Biol., 138, 99 (1944).</ref>]] | ||
==See also== | ==See also== | ||
*[[Chloropyramine]] (chloro instead of methoxy) | *[[Chloropyramine]] (chloro instead of methoxy) | ||
Revision as of 12:45, 9 April 2015
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| Synonyms | N-[2-(dimethylamino)ethyl]-N-[(4-methoxyphenyl)methyl]pyridin-2-amine |
| AHFS/Drugs.com | International Drug Names |
| MedlinePlus | a606008 |
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| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C17H23N3O |
| Molar mass | 285.38 g/mol |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Mepyramine, also known as pyrilamine, is a first generation antihistamine, targeting the H1 receptor.[1] However, it rapidly permeates the brain often causing drowsiness. It also has anticholinergic properties. It is used in over-the-counter combination products to treat the common cold and menstrual symptoms.[2] It is also the active ingredient of the topical antihistamine creams Anthisan and Neoantergan, sold for the treatment of insect bites, stings, and nettle rash.
Synthesis
See also
- Chloropyramine (chloro instead of methoxy)
References
- ↑ Parsons, Mike E.; Ganellin, C. Robin (January 2006). "Histamine and its receptors". British Journal of Pharmacology. 147 (S1): S127–S135. doi:10.1038/sj.bjp.0706440. PMC 1760721. PMID 16402096.
- ↑ Active Ingredients for Midol Complete
- ↑ R.J. Horclois, Template:US Patent (1950).
- ↑ Template:Cite doi
- ↑ D. Bovet, R. Horclois, F. Walthert, C.R. Soc. Biol., 138, 99 (1944).
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- H1 receptor antagonists
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