Paramethadione: Difference between revisions

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Paramethadione
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy; category	US: D (Evidence of risk) ; ;
ATC code	N03AC01 (WHO) ;
Pharmacokinetic data
Protein binding	Not significant
Identifiers
	IUPAC name (RS)-5-ethyl-3,5-dimethyl-oxazolidine-2,4-dione;
CAS Number	115-67-3;
PubChem CID	8280;
DrugBank	DB00617 ;
ChemSpider	7979 ;
UNII	Z615FRW64N;
KEGG	D00495 ;
ChEMBL	ChEMBL1100 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C7H11NO3
Molar mass	157.167 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C1N(C(=O)OC1(C)CC)C;
	InChI InChI=1S/C7H11NO3/c1-4-7(2)5(9)8(3)6(10)11-7/h4H2,1-3H3 ; Key:VQASKUSHBVDKGU-UHFFFAOYSA-N ;
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VisualWikitext

Revision as of 18:09, 9 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Paramethadione is an anticonvulsant in the oxazolidinedione class. It is associated with fetal trimethadione syndrome, which is also known as paramethadione syndrome.^[1]

Chemistry

Paramethadione, 5-ethyl-3,5-dimethyloxazolidine-2,4-dione, differs from trimethadione only in the substitution of one methyl group with an ethyl group. It is synthesized in a completely analogous manner, except that it comes from 2-hydroxy-2-methylbutyric acid instead of 2-hydroxyisobutyric acid.

M.A. Spielman, Template:US Patent (1951).

References

↑ Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes - Retrieved January 2007.

External links

Template:DiseasesDB
Hoffman, D; Chun A (1975). "Paramethadione and metabolite serum levels in humans after a single oral paramethadione dose". J Pharm Sci. 64 (10): 1702–1703. doi:10.1002/jps.2600641027. PMID 1185541.

Template:Anticonvulsants

This anticonvulsant-related article is a stub. You can help Wikipedia by expanding it.

[1] Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes - Retrieved January 2007.

[1]

@@ Line 2: / Line 2: @@
 | verifiedrevid = 416113944
 | IUPAC_name = (''RS'')-5-ethyl-3,5-dimethyl-oxazolidine-2,4-dione
-| image = Paramethadione.svg
+| image = Paramethadione.png
 | width = 250px
 | imagename = 1 : 1 mixture (racemate)
@@ Line 55: / Line 55: @@
 | StdInChIKey = VQASKUSHBVDKGU-UHFFFAOYSA-N
 }}
+                     __NOTOC__
+{{SI}}
+{{CMG}}
+==Overview==
 '''Paramethadione''' is an [[anticonvulsant]] in the [[oxazolidinedione]] class. It is associated with [[fetal trimethadione syndrome]], which is also known as paramethadione syndrome.<ref>[http://www.nlm.nih.gov/cgi/jablonski/syndrome_cgi?term=paramethadione+syndrome&field=name Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes] - Retrieved January 2007.</ref>
 ==Chemistry==
 Paramethadione, 5-ethyl-3,5-dimethyloxazolidine-2,4-dione, differs from [[trimethadione]] only in the substitution of one methyl group with an ethyl group. It is synthesized in a completely analogous manner, except that it comes from 2-hydroxy-2-methylbutyric acid instead of 2-hydroxyisobutyric acid.
 *M.A. Spielman, {{US Patent|2575693}} (1951).
 ==References==
-{{reflist}}
+{{Reflist|2}}
 ==External links==
 * {{DiseasesDB|33106}}
 * {{cite journal | last = Hoffman | first = D |author2=Chun A | title = Paramethadione and metabolite serum levels in humans after a single oral paramethadione dose | journal = J Pharm Sci | volume = 64 | issue = 10 | pages = 1702–1703 | year = 1975 | pmid = 1185541 | doi = 10.1002/jps.2600641027}}
 {{Anticonvulsants}}

Clinical data

AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy category	US: D (Evidence of risk)
ATC code	N03AC01 (WHO)
Pharmacokinetic data
Protein binding	Not significant
Identifiers
IUPAC name (RS)-5-ethyl-3,5-dimethyl-oxazolidine-2,4-dione
CAS Number	115-67-3
PubChem CID	8280
DrugBank	DB00617^Y
ChemSpider	7979^Y
UNII	Z615FRW64N
KEGG	D00495^Y
ChEMBL	ChEMBL1100^Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₇H₁₁NO₃
Molar mass	157.167 g/mol
3D model (JSmol)	Interactive image
SMILES O=C1N(C(=O)OC1(C)CC)C
InChI InChI=1S/C7H11NO3/c1-4-7(2)5(9)8(3)6(10)11-7/h4H2,1-3H3^Y Key:VQASKUSHBVDKGU-UHFFFAOYSA-N^Y
(verify)