Creutzfeldt-Jakob disease other diagnostic studies: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Creutzfeldt-Jakob disease}} | {{Creutzfeldt-Jakob disease}} | ||
{{CMG}} | {{CMG}} | ||
==Overview== | ==Overview== | ||
[[EEG]] findings of | *[[Biopsy]] of the [[brain]] tissue is the definitive diagnostic test for Creutzfeldt-Jakob disease, but is not usually performed. [[EEG]] findings are not diagnostic of CJD, but may help in the diagnosis of CJD. Typical EEG findings in Creutzfeldt-Jakob disease include periodic biphasic or triphasic sharp wave complexes (PSWCs). Periodic synchronous discharges (PSDs) occur either before or in synchronicity with [[myoclonus]].<ref name="Hayashi-1992">{{Cite journal | last1 = Hayashi | first1 = R. | last2 = Hanyu | first2 = N. | last3 = Kuwabara | first3 = T. | last4 = Moriyama | first4 = S. | title = Serial computed tomographic and electroencephalographic studies in Creutzfeldt-Jakob disease. | journal = Acta Neurol Scand | volume = 85 | issue = 3 | pages = 161-5 | month = Mar | year = 1992 | doi = | PMID = 1574996 }}</ref> | ||
==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
===Electroencephalography=== | ===Electroencephalography=== | ||
[[EEG]] findings are not diagnostic of CJD but | *[[EEG]] findings are not diagnostic of CJD, but may help in the diagnosis of CJD. | ||
Typical EEG findings in | *Periodic synchronous discharges (PSDs) occur either before or in synchronicity with [[myoclonus]].<ref name="Hayashi-1992">{{Cite journal | last1 = Hayashi | first1 = R. | last2 = Hanyu | first2 = N. | last3 = Kuwabara | first3 = T. | last4 = Moriyama | first4 = S. | title = Serial computed tomographic and electroencephalographic studies in Creutzfeldt-Jakob disease. | journal = Acta Neurol Scand | volume = 85 | issue = 3 | pages = 161-5 | month = Mar | year = 1992 | doi = | PMID = 1574996 }}</ref> | ||
*Typical EEG findings in Creutzfeldt-Jakob disease include periodic biphasic or triphasic sharp wave complexes (PSWCs). | |||
*Periodic sharp wave complexes can differentiate sporadic Creutzfeldt-Jakob disease (present waves) from familial and variant types of Creutzfeldt-Jakob disease and other prion diseases (absent waves).<ref name="Steinhoff-2004">{{Cite journal | last1 = Steinhoff | first1 = BJ. | last2 = Zerr | first2 = I. | last3 = Glatting | first3 = M. | last4 = Schulz-Schaeffer | first4 = W. | last5 = Poser | first5 = S. | last6 = Kretzschmar | first6 = HA. | title = Diagnostic value of periodic complexes in Creutzfeldt-Jakob disease. | journal = Ann Neurol | volume = 56 | issue = 5 | pages = 702-8 | month = Nov | year = 2004 | doi = 10.1002/ana.20261 | PMID = 15449324 }}</ref> | |||
===Biopsy=== | ===Biopsy=== | ||
*Deposits of [[prion]] protein (scrapie), [[PrpSc|PrP<SUP>Sc</SUP>]], can be found in the [[skeletal muscle]] and/or the [[spleen]] (approximately 30% of cases). | |||
*Diagnosis of [[vCJD]] can be supported by biopsy of the [[tonsils]], which harbor significant amounts of PrpSc. | |||
*[[Biopsy]] of the [[brain]] tissue is the definitive diagnostic test, but is not usually performed. | |||
==Gallery== | ==Gallery== | ||
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{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
[[Category:Infectious disease]] | [[Category:Infectious disease]] | ||
[[Category:Neurology]] | [[Category:Neurology]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Transmissible spongiform encephalopathies]] | [[Category:Transmissible spongiform encephalopathies]] | ||
Revision as of 20:26, 22 March 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
- Biopsy of the brain tissue is the definitive diagnostic test for Creutzfeldt-Jakob disease, but is not usually performed. EEG findings are not diagnostic of CJD, but may help in the diagnosis of CJD. Typical EEG findings in Creutzfeldt-Jakob disease include periodic biphasic or triphasic sharp wave complexes (PSWCs). Periodic synchronous discharges (PSDs) occur either before or in synchronicity with myoclonus.[1]
Other Diagnostic Studies
Electroencephalography
- EEG findings are not diagnostic of CJD, but may help in the diagnosis of CJD.
- Periodic synchronous discharges (PSDs) occur either before or in synchronicity with myoclonus.[1]
- Typical EEG findings in Creutzfeldt-Jakob disease include periodic biphasic or triphasic sharp wave complexes (PSWCs).
- Periodic sharp wave complexes can differentiate sporadic Creutzfeldt-Jakob disease (present waves) from familial and variant types of Creutzfeldt-Jakob disease and other prion diseases (absent waves).[2]
Biopsy
- Deposits of prion protein (scrapie), PrPSc, can be found in the skeletal muscle and/or the spleen (approximately 30% of cases).
- Diagnosis of vCJD can be supported by biopsy of the tonsils, which harbor significant amounts of PrpSc.
- Biopsy of the brain tissue is the definitive diagnostic test, but is not usually performed.
Gallery
-
![Micrograph of brain tissue reveals the cytoarchitectural histopathologic changes found in bovine spongiform encephalopathy. From Public Health Image Library (PHIL). [3]](/images/c/cd/Creutzfeldt_jakob04.jpeg)
Micrograph of brain tissue reveals the cytoarchitectural histopathologic changes found in bovine spongiform encephalopathy. From Public Health Image Library (PHIL). [3] -
![Photomicrograph of brain tissue stained with H&E reveals the presence of prominent spongiotic changes in the cortex, and loss of neurons in a case of variant Creutzfeldt-Jakob disease (100x mag). From Public Health Image Library (PHIL). [3]](/images/9/90/Creutzfeldt_jakob03.jpeg)
Photomicrograph of brain tissue stained with H&E reveals the presence of prominent spongiotic changes in the cortex, and loss of neurons in a case of variant Creutzfeldt-Jakob disease (100x mag). From Public Health Image Library (PHIL). [3] -
![Photomicrograph of brain tissue stained with H&E reveals the presence of prominent spongiotic changes in the cortex, and loss of neurons in a case of variant Creutzfeldt-Jakob disease (100x mag). From Public Health Image Library (PHIL). [3]](/images/4/44/Creutzfeldt_jakob02.jpeg)
Photomicrograph of brain tissue stained with H&E reveals the presence of prominent spongiotic changes in the cortex, and loss of neurons in a case of variant Creutzfeldt-Jakob disease (100x mag). From Public Health Image Library (PHIL). [3] -
![Neural tissue specimen harvested from a scrapie-affected mouse, revealed the presence of prion protein stained in red. From Public Health Image Library (PHIL). [3]](/images/c/cc/Creutzfeldt_jakob01.jpeg)
Neural tissue specimen harvested from a scrapie-affected mouse, revealed the presence of prion protein stained in red. From Public Health Image Library (PHIL). [3]
![Micrograph of brain tissue reveals the cytoarchitectural histopathologic changes found in bovine spongiform encephalopathy. From Public Health Image Library (PHIL). [3]](/index.php/File:Creutzfeldt_jakob04.jpeg)
![Photomicrograph of brain tissue stained with H&E reveals the presence of prominent spongiotic changes in the cortex, and loss of neurons in a case of variant Creutzfeldt-Jakob disease (100x mag). From Public Health Image Library (PHIL). [3]](/index.php/File:Creutzfeldt_jakob03.jpeg)
![Photomicrograph of brain tissue stained with H&E reveals the presence of prominent spongiotic changes in the cortex, and loss of neurons in a case of variant Creutzfeldt-Jakob disease (100x mag). From Public Health Image Library (PHIL). [3]](/index.php/File:Creutzfeldt_jakob02.jpeg)
![Neural tissue specimen harvested from a scrapie-affected mouse, revealed the presence of prion protein stained in red. From Public Health Image Library (PHIL). [3]](/index.php/File:Creutzfeldt_jakob01.jpeg)
References
- ↑ 1.0 1.1 Hayashi, R.; Hanyu, N.; Kuwabara, T.; Moriyama, S. (1992). "Serial computed tomographic and electroencephalographic studies in Creutzfeldt-Jakob disease". Acta Neurol Scand. 85 (3): 161–5. PMID 1574996. Unknown parameter
|month=ignored (help) - ↑ Steinhoff, BJ.; Zerr, I.; Glatting, M.; Schulz-Schaeffer, W.; Poser, S.; Kretzschmar, HA. (2004). "Diagnostic value of periodic complexes in Creutzfeldt-Jakob disease". Ann Neurol. 56 (5): 702–8. doi:10.1002/ana.20261. PMID 15449324. Unknown parameter
|month=ignored (help) - ↑ 3.0 3.1 3.2 3.3 "Public Health Image Library (PHIL)".