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Tamoxifen citrate has been used for the treatment of breast cancer for its selective estrogen receptor modulator action. It also inhibits the production of transforming growth factor-beta (TGF-b) and insulin-like growth factor [2,3]. TGF-b has important roles in the formation of fibrosis such as the modulation of inflammation, wound repair, and immunity by decreasing lymphocyte proliferation and encouraging growth of fibroblasts [4]. These effects have been studied in postoperative adhesions [5], keloid fibroblast proliferation, and reducing collagen production [6,7]. In this study, we aimed to investigate possible effects of tamoxifen on progression, prevention, and treatment of the fibrotic pulmonary silicosis disease considering the anti-fibrotic effect shown in aforementioned studies<ref name="pmid25218282">{{cite journal| author=Yoldas O, Karaca T, Bilgin BC, Yilmaz OH, Simsek GG, Alici IO et al.| title=Tamoxifen citrate: a glimmer of hope for silicosis. | journal=J Surg Res | year= 2015 | volume= 193 | issue= 1 | pages= 429-34 | pmid=25218282 | doi=10.1016/j.jss.2014.08.013 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25218282  }} </ref>
 


==References==
==References==

Revision as of 19:39, 17 June 2015

Silicosis Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Silicosis is an irreversible condition with currently no cure. Treatment options currently focus on alleviating the symptoms and preventing complications.

Medical Therapy

  • Patients with an evidence of silicosis on chest x-ray should avoid further exposure to silica

Supportive therapy

  • Smoking cessation
  • Bronchodilators to facilitate breathing if airflow limitation present on spirometry.
  • Vaccination against influenza and pneumococcus
  • Supplemental oxygen (if indicated) to prevent complications of chronic hypoxemia





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