Silicosis future or investigational therapies: Difference between revisions
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Silicosis is an irreversible condition with no cure. Treatment options currently focus on alleviating the symptoms and preventing complications. | Silicosis is an irreversible condition with no cure. Treatment options currently focus on alleviating the symptoms and preventing complications. | ||
==Future or Investigational Therapies== | ==Future or Investigational Therapies== | ||
Experimental treatments include: | *Experimental treatments include: | ||
:*Systemic glucocorticoid therapy : | |||
::*In chronic silicosis with COPD flare up, prednisolone has been used and this resulted in statistically (although not clinically) significant improvements in lung volumes, carbon monoxide diffusing capacity, and partial pressure of arterial oxygen.<ref name="pmid2008993">{{cite journal| author=Sharma SK, Pande JN, Verma K| title=Effect of prednisolone treatment in chronic silicosis. | journal=Am Rev Respir Dis | year= 1991 | volume= 143 | issue= 4 Pt 1 | pages= 814-21 | pmid=2008993 | doi=10.1164/ajrccm/143.4_Pt_1.814 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2008993 }} </ref> | |||
* Whole-lung lavage (see [[Bronchoalveolar lavage]]) | * Whole-lung lavage (see [[Bronchoalveolar lavage]]) | ||
* Inhalation of powdered aluminium, d-penicillamine and polyvinyl pyridine-N-oxide. | * Inhalation of powdered aluminium, d-penicillamine and polyvinyl pyridine-N-oxide. | ||
Revision as of 19:38, 17 June 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Silicosis is an irreversible condition with no cure. Treatment options currently focus on alleviating the symptoms and preventing complications.
Future or Investigational Therapies
- Experimental treatments include:
- Systemic glucocorticoid therapy :
- In chronic silicosis with COPD flare up, prednisolone has been used and this resulted in statistically (although not clinically) significant improvements in lung volumes, carbon monoxide diffusing capacity, and partial pressure of arterial oxygen.[1]
- Whole-lung lavage (see Bronchoalveolar lavage)
- Inhalation of powdered aluminium, d-penicillamine and polyvinyl pyridine-N-oxide.
- Corticosteroid therapy.
- The herbal extract tetrandine may slow progression of silicosis.[2]
References
- ↑ Sharma SK, Pande JN, Verma K (1991). "Effect of prednisolone treatment in chronic silicosis". Am Rev Respir Dis. 143 (4 Pt 1): 814–21. doi:10.1164/ajrccm/143.4_Pt_1.814. PMID 2008993.
- ↑ Template:Cite paper