Lung cancer causes: Difference between revisions
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==Overview== | ==Overview== | ||
The | The direct cause of lung cancers is DNA mutations that often result in activation of proto-oncogenes (e.g. '''K-RAS''')or the inactivation of tumors suppressor genes (e.g. '''TP53'''). The risk of these genetic mutations may be increased following exposure to environmental components, which are regarded as risk factors that predispose to the development of lung cancer. | ||
==Causes== | ==Causes== | ||
*The direct cause of lung cancers is DNA mutations that often result in activation of proto-oncogenes (e.g. '''K-RAS''')or the inactivation of tumors suppressor genes (e.g. '''TP53'''). | |||
*The risk of these genetic mutations may be increased following exposure to environmental components, which are regarded as risk factors that predispose to the development of lung cancer. | |||
*To view a comprehensive list of risk factors that increase the risk of lung cancer, '''click''' [[Lung cancer #Risk factors|here]] | |||
* Cigarette smoking is the leading cause of lung cancer. Risk is determined by | * Cigarette smoking is the leading cause of lung cancer. Risk is determined by | ||
** The more cigarettes you smoke per day | ** The more cigarettes you smoke per day | ||
Revision as of 21:00, 3 August 2015
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Lung cancer causes On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Kim-Son H. Nguyen, M.D., M.P.A., Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA, Cafer Zorkun, M.D., Ph.D. [2]
Overview
The direct cause of lung cancers is DNA mutations that often result in activation of proto-oncogenes (e.g. K-RAS)or the inactivation of tumors suppressor genes (e.g. TP53). The risk of these genetic mutations may be increased following exposure to environmental components, which are regarded as risk factors that predispose to the development of lung cancer.
Causes
- The direct cause of lung cancers is DNA mutations that often result in activation of proto-oncogenes (e.g. K-RAS)or the inactivation of tumors suppressor genes (e.g. TP53).
- The risk of these genetic mutations may be increased following exposure to environmental components, which are regarded as risk factors that predispose to the development of lung cancer.
- To view a comprehensive list of risk factors that increase the risk of lung cancer, click here
- Cigarette smoking is the leading cause of lung cancer. Risk is determined by
- The more cigarettes you smoke per day
- The earlier you started smoking
There is no evidence that smoking low-tar cigarettes lowers the risk. Secondhand smoke (breathing the smoke of others) increases your risk of lung cancer. According to the American Cancer Society, an estimated 3,000 nonsmoking adults will die each year from lung cancer related to breathing secondhand smoke.
- Exposure to Radon is the second leading cause of lung cancer. Alpha decay products from Radon causes the damage.
- There is a good chance of lung cancer in aluminum workers, gasification and cooking coal, the foundry industry, the production of isopropyl alcohol, the rubber industry, and the mining of hematite.
- Long term exposure to Asbestos can also lead to lung cancer as well as another form of cancer, Mesothelioma.
Also, chances of lung cancer is increased by the presence of certain risk factors.