Filariasis medical therapy: Difference between revisions
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===Antimicrobial Regimen=== | ===Antimicrobial Regimen=== | ||
* '''Filariasis'''<ref>{{cite web | title = Drugs for Parasitic Infections (Treatment Guidelines from The Medical Letter) | url = http://secure.medicalletter.org/para }}</ref><ref name="pmid20739055">{{cite journal| author=Taylor MJ, Hoerauf A, Bockarie M| title=Lymphatic filariasis and onchocerciasis. | journal=Lancet | year= 2010 | volume= 376 | issue= 9747 | pages= 1175-85 | pmid=20739055 | doi=10.1016/S0140-6736(10)60586-7 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20739055 }} </ref><ref name="pmid22632644">{{cite journal| author=Knopp S, Steinmann P, Hatz C, Keiser J, Utzinger J| title=Nematode infections: filariases. | journal=Infect Dis Clin North Am | year= 2012 | volume= 26 | issue= 2 | pages= 359-81 | pmid=22632644 | doi=10.1016/j.idc.2012.02.005 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22632644 }}</ref> | |||
:* 1. '''Lymphatic filariasis caused by Wuchereria bancrofti, Brugia malayi, Brugia timori''' | |||
::* Preferred regimen: [[Diethylcarbamazine]] 6 mg/kd/day PO tid for 12 days (single dose if patient will continue to live in endemic area or is younger than 9 years old) | |||
:* 2. '''Loa loa filariasis''' | |||
::* 2.1 '''Symptomatic loiasis with < 8,000 microfilariae/mL''' | |||
:::* Preferred regimen: [[Diethylcarbamazine]] 8–10 mg/kd/day PO tid for 21 days | |||
::* 2.2 '''Symptomatic loiasis, with < 8,000 microfilariae/mL and failed 2 rounds DEC''' | |||
:::* Preferred regimen: [[Albendazole]] 200 mg PO bid for 21 days | |||
::* 2.3 '''Symptomatic loiasis, with ≥ 8,000 microfilariae/ml to suppress microfilaremia prior to treatment with DEC''' | |||
:::* Preferred regimen: [[Albendazole]] 200 mg PO bid for 21 days | |||
::* 2.4 '''Symptomatic loiasis, with ≥ 8,000 microfilariae/mL''' | |||
:::* Preferred regimen: Apheresis followed by [[Diethylcarbamazine]] | |||
:::* Note: Apheresis should be performed at an institution with experience in using this therapeutic modality for loiasis. | |||
:* 3. '''River blindness caused by Onchocerca volvulus''' | |||
::* Preferred regimen: [[Ivermectin]] 150 μg/kg PO single dose, repeated every 6-12 mos until asymptomatic | |||
::* Alternative regimen: [[Doxycycline]] 100 mg/day PO for 6 weeks, alone or followed by [[Ivermectin]] 150 μg/kg PO single dose | |||
::* Note: Do <u>NOT</u> administer Diethylcarbamazine where onchocerciasis is endemic due to increased risk for severe local inflammation in patients with ocular microfilariae. | |||
:* 4. '''Mansonella streptocerca''' | |||
:* 5. '''Mansonella ozzardi''' | |||
:* 6. '''Mansonella perstans''' | |||
==References== | ==References== |
Revision as of 23:26, 30 July 2015
Filariasis Microchapters |
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Filariasis medical therapy On the Web |
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Risk calculators and risk factors for Filariasis medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Different drugs are recommended for the treatment of filariasis depending on the specific causal pathogen.
Medical Therapy
Antimicrobial Regimen
- 1. Lymphatic filariasis caused by Wuchereria bancrofti, Brugia malayi, Brugia timori
- Preferred regimen: Diethylcarbamazine 6 mg/kd/day PO tid for 12 days (single dose if patient will continue to live in endemic area or is younger than 9 years old)
- 2. Loa loa filariasis
- 2.1 Symptomatic loiasis with < 8,000 microfilariae/mL
- Preferred regimen: Diethylcarbamazine 8–10 mg/kd/day PO tid for 21 days
- 2.2 Symptomatic loiasis, with < 8,000 microfilariae/mL and failed 2 rounds DEC
- Preferred regimen: Albendazole 200 mg PO bid for 21 days
- 2.3 Symptomatic loiasis, with ≥ 8,000 microfilariae/ml to suppress microfilaremia prior to treatment with DEC
- Preferred regimen: Albendazole 200 mg PO bid for 21 days
- 2.4 Symptomatic loiasis, with ≥ 8,000 microfilariae/mL
- Preferred regimen: Apheresis followed by Diethylcarbamazine
- Note: Apheresis should be performed at an institution with experience in using this therapeutic modality for loiasis.
- 3. River blindness caused by Onchocerca volvulus
- Preferred regimen: Ivermectin 150 μg/kg PO single dose, repeated every 6-12 mos until asymptomatic
- Alternative regimen: Doxycycline 100 mg/day PO for 6 weeks, alone or followed by Ivermectin 150 μg/kg PO single dose
- Note: Do NOT administer Diethylcarbamazine where onchocerciasis is endemic due to increased risk for severe local inflammation in patients with ocular microfilariae.
- 4. Mansonella streptocerca
- 5. Mansonella ozzardi
- 6. Mansonella perstans
References
- ↑ "Drugs for Parasitic Infections (Treatment Guidelines from The Medical Letter)".
- ↑ Taylor MJ, Hoerauf A, Bockarie M (2010). "Lymphatic filariasis and onchocerciasis". Lancet. 376 (9747): 1175–85. doi:10.1016/S0140-6736(10)60586-7. PMID 20739055.
- ↑ Knopp S, Steinmann P, Hatz C, Keiser J, Utzinger J (2012). "Nematode infections: filariases". Infect Dis Clin North Am. 26 (2): 359–81. doi:10.1016/j.idc.2012.02.005. PMID 22632644.