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{{Lung cancer}} | {{Lung cancer}} | ||
{{CMG}}; '''Assistant Editor(s)-In-Chief:''' | {{CMG}}; '''Assistant Editor(s)-In-Chief:''' {{YD}} | ||
==Overview==Prior to the introduction of cigarette smoking and industrial carcinogens, lung cancer was thought to be a rare disease. Of all tumors detected an autopsy, lung cancer accounted for only 1% of cancers in the 1800s. The majority of cases of lung cancer were associated with occupational hazards due to radon exposure. The association between lung cancer and smoking was not defined until the mid-20th century. | |||
==Historical Perspective== | ==Historical Perspective== | ||
*Prior to the introduction of cigarette smoking and industrial carcinogens, lung cancer was thought to be a rare disease. Of all tumors detected an autopsy, lung cancer accounted for only 1% of cancers in the 1800s.<ref name="pmid11606795">{{cite journal |author=Witschi H |title=A short history of lung cancer |journal=[[Toxicological Sciences : an Official Journal of the Society of Toxicology]] |volume=64 |issue=1 |pages=4–6 |year=2001 |month=November |pmid=11606795 |doi= |url=http://toxsci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=11606795 |accessdate=2011-12-09}}</ref> | *Prior to the introduction of cigarette smoking and industrial carcinogens, lung cancer was thought to be a rare disease. Of all tumors detected an autopsy, lung cancer accounted for only 1% of cancers in the 1800s.<ref name="pmid11606795">{{cite journal |author=Witschi H |title=A short history of lung cancer |journal=[[Toxicological Sciences : an Official Journal of the Society of Toxicology]] |volume=64 |issue=1 |pages=4–6 |year=2001 |month=November |pmid=11606795 |doi= |url=http://toxsci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=11606795 |accessdate=2011-12-09}}</ref> | ||
*The majority of cases of lung cancer were associated with occupational hazards. Death among miners was reported to be caused by ''Bergkrankheit'' (mountain sickness).<ref name="pmid11606795">{{cite journal |author=Witschi H |title=A short history of lung cancer |journal=[[Toxicological Sciences : an Official Journal of the Society of Toxicology]] |volume=64 |issue=1 |pages=4–6 |year=2001 |month=November |pmid=11606795 |doi= |url=http://toxsci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=11606795 |accessdate=2011-12-09}}</ref> | *The majority of cases of lung cancer were associated with occupational hazards. Death among miners was reported to be caused by ''Bergkrankheit'' (mountain sickness).<ref name="pmid11606795">{{cite journal |author=Witschi H |title=A short history of lung cancer |journal=[[Toxicological Sciences : an Official Journal of the Society of Toxicology]] |volume=64 |issue=1 |pages=4–6 |year=2001 |month=November |pmid=11606795 |doi= |url=http://toxsci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=11606795 |accessdate=2011-12-09}}</ref> | ||
*In 1924, radon gas was first reported to be a prominent cause of lung cancer among miners.<ref name="pmid11606795">{{cite journal |author=Witschi H |title=A short history of lung cancer |journal=[[Toxicological Sciences : an Official Journal of the Society of Toxicology]] |volume=64 |issue=1 |pages=4–6 |year=2001 |month=November |pmid=11606795 |doi= |url=http://toxsci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=11606795 |accessdate=2011-12-09}}</ref> | *In 1924, radon gas was first reported to be a prominent cause of lung cancer among miners.<ref name="pmid11606795">{{cite journal |author=Witschi H |title=A short history of lung cancer |journal=[[Toxicological Sciences : an Official Journal of the Society of Toxicology]] |volume=64 |issue=1 |pages=4–6 |year=2001 |month=November |pmid=11606795 |doi= |url=http://toxsci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=11606795 |accessdate=2011-12-09}}</ref> | ||
*The association between lung cancer and smoking was not defined until the mid-20th century. The first reports between lung cancer and smoking were often confounded by gender, given that men were more likely to be smokers compared to women. | *The association between lung cancer and smoking was not defined until the mid-20th century. The first reports between lung cancer and smoking were often confounded by gender, given that men were more likely to be smokers compared to women. | ||
*The 1969 handbook Springer Handbook of Special Pathology is considered the landmark publication that highlighted the role of smoking in the development of lung cancer in over 25 pages.<ref name="pmid11606795">{{cite journal |author=Witschi H |title=A short history of lung cancer |journal=[[Toxicological Sciences : an Official Journal of the Society of Toxicology]] |volume=64 |issue=1 |pages=4–6 |year=2001 |month=November |pmid=11606795 |doi= |url=http://toxsci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=11606795 |accessdate=2011-12-09}}</ref> | *The 1969 handbook Springer Handbook of Special Pathology is considered the landmark publication that highlighted the role of smoking in the development of lung cancer in over 25 pages.<ref name="pmid11606795">{{cite journal |author=Witschi H |title=A short history of lung cancer |journal=[[Toxicological Sciences : an Official Journal of the Society of Toxicology]] |volume=64 |issue=1 |pages=4–6 |year=2001 |month=November |pmid=11606795 |doi= |url=http://toxsci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=11606795 |accessdate=2011-12-09}}</ref> | ||
*Although chemotherapy had always been regarded to be ineffective in the management of lung cancer, cisplatin-based chemotherapy emerged in the 1980s and demonstrated modest efficacy in the reduction of turmo-related symptoms and improvement of quality of life. | *Although chemotherapy had always been regarded to be ineffective in the management of lung cancer, cisplatin-based chemotherapy emerged in the 1980s and demonstrated modest efficacy in the reduction of turmo-related symptoms and improvement of quality of life. | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
{{Tumors}} | {{Tumors}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
Revision as of 20:11, 3 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Assistant Editor(s)-In-Chief: Yazan Daaboul, M.D.
==Overview==Prior to the introduction of cigarette smoking and industrial carcinogens, lung cancer was thought to be a rare disease. Of all tumors detected an autopsy, lung cancer accounted for only 1% of cancers in the 1800s. The majority of cases of lung cancer were associated with occupational hazards due to radon exposure. The association between lung cancer and smoking was not defined until the mid-20th century.
Historical Perspective
- Prior to the introduction of cigarette smoking and industrial carcinogens, lung cancer was thought to be a rare disease. Of all tumors detected an autopsy, lung cancer accounted for only 1% of cancers in the 1800s.[1]
- The majority of cases of lung cancer were associated with occupational hazards. Death among miners was reported to be caused by Bergkrankheit (mountain sickness).[1]
- In 1924, radon gas was first reported to be a prominent cause of lung cancer among miners.[1]
- The association between lung cancer and smoking was not defined until the mid-20th century. The first reports between lung cancer and smoking were often confounded by gender, given that men were more likely to be smokers compared to women.
- The 1969 handbook Springer Handbook of Special Pathology is considered the landmark publication that highlighted the role of smoking in the development of lung cancer in over 25 pages.[1]
- Although chemotherapy had always been regarded to be ineffective in the management of lung cancer, cisplatin-based chemotherapy emerged in the 1980s and demonstrated modest efficacy in the reduction of turmo-related symptoms and improvement of quality of life.
References
- ↑ 1.0 1.1 1.2 1.3 Witschi H (2001). "A short history of lung cancer". Toxicological Sciences : an Official Journal of the Society of Toxicology. 64 (1): 4–6. PMID 11606795. Retrieved 2011-12-09. Unknown parameter
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