Hamartoma classification: Difference between revisions
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==Overview== | ==Overview== | ||
Hamartomas may be classified into subtypes based on their '''location''' and '''associated conditions'''. | |||
==Classification== | ==Classification== | ||
*[[ | Based on the genetic mutations, hereditary hamartomatous syndromes carry different gene mutations. | ||
*[[Peutz-Jeghers syndrome]] | |||
* | ===Familial inheritance=== | ||
* | |||
*[[ | All the syndromes are inherited in the autosomal dominant manner and are conditioned by mutations in four genes, which are: BMPR1A, SMAD4, PTEN and STK11. | ||
* | |||
* | * [[Juvenile polyposis syndrome]] | ||
* | * [[Peutz-Jeghers syndrome]] | ||
* | * Hereditary mixed polyposis syndrome | ||
* | * PTEN hamartoma tumour syndrome | ||
* | * [[Cowden syndrome]] | ||
* Bannayan-Riley-Ruvalcaba syndrome | |||
* Proteus’es syndrome | |||
===Location=== | |||
Based on the location, hamartomas can be classified into the following sub-types: | |||
'''* Bone-forming tumors''' | |||
'''* Cartilage-forming tumors''' | |||
'''* '''Fiber-forming tumors''' | |||
::Nonossifying fibroma | |||
::Fibrous dysplasia | |||
::Mazabraud syndrome | |||
'''* Benign non–matrix-forming tumors''' | |||
==References== | ==References== | ||
Revision as of 17:31, 8 December 2015
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Hamartoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Hamartoma classification On the Web |
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American Roentgen Ray Society Images of Hamartoma classification |
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Risk calculators and risk factors for Hamartoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]{AE}}Maria Fernanda Villarreal, M.D. [2]
Overview
Hamartomas may be classified into subtypes based on their location and associated conditions.
Classification
Based on the genetic mutations, hereditary hamartomatous syndromes carry different gene mutations.
Familial inheritance
All the syndromes are inherited in the autosomal dominant manner and are conditioned by mutations in four genes, which are: BMPR1A, SMAD4, PTEN and STK11.
- Juvenile polyposis syndrome
- Peutz-Jeghers syndrome
- Hereditary mixed polyposis syndrome
- PTEN hamartoma tumour syndrome
- Cowden syndrome
- Bannayan-Riley-Ruvalcaba syndrome
- Proteus’es syndrome
Location
Based on the location, hamartomas can be classified into the following sub-types:
* Bone-forming tumors
* Cartilage-forming tumors
* Fiber-forming tumors
- Nonossifying fibroma
- Fibrous dysplasia
- Mazabraud syndrome
* Benign non–matrix-forming tumors