Insulinoma pathophysiology: Difference between revisions
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{{Insulinoma}} | {{Insulinoma}} | ||
{{CMG}}{{AE}}{{PSD}} | |||
==Overview== | |||
==Pathophysiology== | |||
*Insulinoma can occur in association with inherited syndrome, such as [[multiple endocrine neoplasia type 1]] or sporadic.<ref name="pmid3498768">{{cite journal| author=Murray PD, McKenzie DT, Swain SL, Kagnoff MF| title=Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression. | journal=J Immunol | year= 1987 | volume= 139 | issue= 8 | pages= 2669-74 | pmid=3498768 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3498768 }} </ref> | |||
*Multiple endocrine neoplasia type 1 is an autosomal dominant disorder caused by alterations of the ''MEN1'' gene located at chromosomal region 11q13. | |||
*Approximately 10% of insulinomas are multiple and 10% malignant.<ref> Insulinoma. Dr Yuranga Weerakkody and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/insulinoma</ref> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Endocrinology]] | [[Category:Endocrinology]] | ||
Revision as of 14:17, 1 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Pathophysiology
- Insulinoma can occur in association with inherited syndrome, such as multiple endocrine neoplasia type 1 or sporadic.[1]
- Multiple endocrine neoplasia type 1 is an autosomal dominant disorder caused by alterations of the MEN1 gene located at chromosomal region 11q13.
- Approximately 10% of insulinomas are multiple and 10% malignant.[2]
References
- ↑ Murray PD, McKenzie DT, Swain SL, Kagnoff MF (1987). "Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression". J Immunol. 139 (8): 2669–74. PMID 3498768.
- ↑ Insulinoma. Dr Yuranga Weerakkody and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/insulinoma