Hemophilia classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Haemophilia may be classified into three subtypes based on lack of functional clotting factors:Haemophilia A , Haemophilia B, Haemophilia C.

Classification

Hemophilia may be classified as severe, moderate or mild. This is based on the levels of Factor VIII or Factor IX depending on the type of hemophilia.

• Haemophilia A is a recessive X-linked genetic disorder involving a lack of functional clotting Factor VIII and represents 80% of haemophilia cases.
• Haemophilia B is a recessive X-linked genetic disorder involving a lack of functional clotting Factor IX. It comprises approximately 20% of haemophilia cases.
• Haemophilia C is an autosomal genetic disorder (i.e. not X-linked) involving a lack of functional clotting Factor XI. Haemophilia C is not completely recessive, as heterozygous individuals also show increased bleeding.

Severity	Levels of Factor VIII (8) or IX (9) in the blood
Normal (person who does not have hemophilia)	50% to 100%
Mild hemophilia	Greater than 5% but less than 50%
Moderate hemophilia	1% to 5%
Severe hemophilia	Less than 1%
Adapted from CDC Hemophilia Diagnosis> "CDC Hemophilia Diagnosis".