Brain Stem Gliomas pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
The brain stem gliomas are classified into 4 subtypes, and each has its distinct histological features: | The brain stem gliomas are classified into 4 subtypes, and each has its distinct histological features: | ||
*Diffuse astrocytoma | *'''Diffuse astrocytoma''' | ||
**Usually fibrillary astrocytomas | **Usually fibrillary astrocytomas | ||
**WHO grades II-IV | **''WHO grades II-IV'' | ||
**Grade does not impact on prognosis, and thus biopsy is usually not necessary | **Grade does not impact on prognosis, and thus biopsy is usually not necessary | ||
*Focal glioma | *'''Focal glioma''' | ||
**Fibrillary astrocytoma (grade II): ''most common histology'' | **Fibrillary astrocytoma (grade II): ''most common histology'' | ||
**Pilocytic astrocytoma | **Pilocytic astrocytoma | ||
**Ganglioglioma | **Ganglioglioma | ||
*(Dorsally) exophytic glioma | *'''(Dorsally) exophytic glioma''' | ||
**Low grade astrocytoma | **Low grade astrocytoma | ||
**Ganglioglioma | **Ganglioglioma | ||
*NF1-associated brainstem glioma | *'''NF1-associated brainstem glioma''' | ||
**Seen in up to 9% of NF1 patients | **Seen in up to 9% of NF1 patients | ||
**Most frequently seen in the medulla | **Most frequently seen in the medulla | ||
Revision as of 18:10, 26 August 2015
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Brain Stem Gliomas Microchapters |
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Brain Stem Gliomas pathophysiology On the Web |
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American Roentgen Ray Society Images of Brain Stem Gliomas pathophysiology |
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Risk calculators and risk factors for Brain Stem Gliomas pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
The brain stem gliomas are classified into 4 subtypes, and each has its distinct histological features:
- Diffuse astrocytoma
- Usually fibrillary astrocytomas
- WHO grades II-IV
- Grade does not impact on prognosis, and thus biopsy is usually not necessary
- Focal glioma
- Fibrillary astrocytoma (grade II): most common histology
- Pilocytic astrocytoma
- Ganglioglioma
- (Dorsally) exophytic glioma
- Low grade astrocytoma
- Ganglioglioma
- NF1-associated brainstem glioma
- Seen in up to 9% of NF1 patients
- Most frequently seen in the medulla
- Appears similar to a sporadic focal brainstem glioma but has an even better prognosis, with little if any progression