Hemophilia differential diagnosis: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
No edit summary
Line 7: Line 7:


==Differentiating Hemophilia with other Diseases==
==Differentiating Hemophilia with other Diseases==
Hemophilia A can be mimicked by [[von Willebrand Disease]]
**[[von Willebrand Disease]]
Additionally, severe cases of [[vitamin K deficiency]] can present similar symptoms to hemophilia. This is because vitamin K is necessary for the human body to produce several protein clotting factors. This vitamin deficiency is rare in adults and older children but is common in newborns. Infants are born with naturally low levels of vitamin K and do not yet have the symbiotic gut flora to properly synthesise their own vitamin K. Bleeding issues due to vitamin K deficiency in infants is known as "haemorrhagic disease of the newborn", to avoid this complication newborns are routinely injected with vitamin K supplements.<ref>{{Cite web | title = Hemophilia Differential diagnosis| url =https://en.wikipedia.org/wiki/Haemophilia }}</ref>
**[[vitamin K deficiency]] or [[Warfarin]]
*The other conditions to be considered includes the following:
**Lupus Anticoagulant
**Lupus Anticoagulant
**Heparin Administration
**Heparin Administration
**[[Disseminated Intravascular Coagulation]]
**[[Disseminated Intravascular Coagulation]]
**Dysfibrinogenemia
**Dysfibrinogenemia
{| style="border: 0px; font-size: 90%; margin: 3px; width: 500px;" align=center
**Thrombocytopenia
|valign=top|
**Early liver failure
|+
**End-staged liver failure
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Condition}}
**[[Uremia]]
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Prothrombin time}}
**Congenital afibrinogenemia
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Partial Thromboplastin Time}}
**[[Factor V]] deficiency
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Bleeding Time}}
**Amyloid purpura
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Platelet Count}}
**Glanzmann's thrombasthenia
|-
**Bernard-soulier syndrome
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Hemophilia A or B
**[[Factor XII]] deficiency
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
**C1INH deficiency<ref>{{Cite web | title = Hemophilia Differential diagnosis| url =https://en.wikipedia.org/wiki/Haemophilia }}</ref>
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
 
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Von Willebrand Disease
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged or Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Thrombocytopenia
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Decreased
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Vitamin K deficiency or Warfarin
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Normal or mildly prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Disseminated Intravascular Coagulation
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Decreased
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Liver failure, early
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Aspirin
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Liver failure, end-stage
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Pronlonged
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Decreased
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Uremia
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Congenital afibrinogenemia
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Factor V deficiency
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Factor X deficiency as seen in amyloid purpura
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Glanzmann's thrombasthenia
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Bernard-Soulier syndrome
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Decreased
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Factor XII deficiency
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Decreased or unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | C1INH deficiency
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Shortened
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #F5F5F5;" colspan=5| <small>Adapted from Wikipedia hemophilia Laboratory Finding> {{cite web| url=https://en.wikipedia.org/wiki/Haemophilia| title=Wikipedia Hemophilia Laboratory Finding  }}</small>
|}


==References==
==References==

Revision as of 21:33, 31 August 2015

Hemophilia Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Hemophilia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Hemophilia differential diagnosis On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Hemophilia differential diagnosis

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Hemophilia differential diagnosis

CDC on Hemophilia differential diagnosis

Hemophilia differential diagnosis in the news

Blogs on Hemophilia differential diagnosis

Directions to Hospitals Treating Hemophilia

Risk calculators and risk factors for Hemophilia differential diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Hemophilia must be differentiated from other diseases that lead to spontaneous bleeding and bleeding following injuries or surgery such as von Willebrand disease, liver failure-early or end stage, thrombocytopenia, vitamin K deficiency, disseminated intravascular coagulation, uremia, congenital afibrinogenemia, factor V deficiency, factor X deficiency as seen in amyloid purpura, glanzmann's thrombasthenia, bernard-soulier syndrome, factor XII deficiency and C1INH deficiency.

Differentiating Hemophilia with other Diseases

References

  1. ↑ "Hemophilia Differential diagnosis".

Template:WH Template:WS

Retrieved from "https://www.wikidoc.org/index.php?title=Hemophilia_differential_diagnosis&oldid=1149405"