Hemophilia causes: Difference between revisions
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==Overview== | ==Overview== | ||
Hemophilia | Hemophilia A, B, and C are caused by [[mutations]] in ''F8'', ''F9'', and ''F11'' [[genes]] respectively. It can also occur as a result of autoantibodies directed against the clotting factors. | ||
==Causes== | ==Causes== | ||
*Hemophilia is caused by a [[mutation]] or change, in one of the [[genes]], that provides instructions for making the clotting factor proteins needed to form a blood clot. This change or [[mutation]] can prevent the clotting protein from working properly or to be missing altogether. These [[genes]] are located on the [[X chromosome]]. Males have one X and one [[Y chromosome]] (XY) and females have two [[X chromosomes]] (XX). Males inherit the X chromosome from their mothers and the [[Y chromosome]] from their fathers. Females inherit one [[X chromosome]] from each parent. A defect in one of the [[genes]] that determines how the body makes blood clotting [[factor VIII]] or IX causes hemophilia. These genes are located on the X chromosomes.<ref>{{Cite web | title =CDC Hemophilia Pathophysiology| url =http://www.cdc.gov/ncbddd/hemophilia/facts.html }}</ref> | *Hemophilia is caused by a [[mutation]] or change, in one of the [[genes]], that provides instructions for making the clotting factor proteins needed to form a blood clot. This change or [[mutation]] can prevent the clotting protein from working properly or to be missing altogether. These [[genes]] are located on the [[X chromosome]]. Males have one X and one [[Y chromosome]] (XY) and females have two [[X chromosomes]] (XX). Males inherit the X chromosome from their mothers and the [[Y chromosome]] from their fathers. Females inherit one [[X chromosome]] from each parent. A defect in one of the [[genes]] that determines how the body makes blood clotting [[factor VIII]] or IX causes hemophilia. These genes are located on the X chromosomes.<ref>{{Cite web | title =CDC Hemophilia Pathophysiology| url =http://www.cdc.gov/ncbddd/hemophilia/facts.html }}</ref> | ||
Revision as of 18:38, 7 January 2019
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Hemophilia Microchapters |
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Diagnosis |
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Case Studies |
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Hemophilia causes On the Web |
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American Roentgen Ray Society Images of Hemophilia causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Hemophilia A, B, and C are caused by mutations in F8, F9, and F11 genes respectively. It can also occur as a result of autoantibodies directed against the clotting factors.
Causes
- Hemophilia is caused by a mutation or change, in one of the genes, that provides instructions for making the clotting factor proteins needed to form a blood clot. This change or mutation can prevent the clotting protein from working properly or to be missing altogether. These genes are located on the X chromosome. Males have one X and one Y chromosome (XY) and females have two X chromosomes (XX). Males inherit the X chromosome from their mothers and the Y chromosome from their fathers. Females inherit one X chromosome from each parent. A defect in one of the genes that determines how the body makes blood clotting factor VIII or IX causes hemophilia. These genes are located on the X chromosomes.[1]
- Another form of the disorder, known as acquired hemophilia, is not caused by inherited gene mutations. This rare condition is characterized by abnormal bleeding into the skin, muscles, or other soft tissues, usually beginning in adulthood. Acquired hemophilia results when the body makes specialized proteins called auto antibodies that attack and disable coagulation factor VIII. The production of auto antibodies is sometimes associated with pregnancy, immune system disorders, cancer, or allergic reactions to certain drugs. In about half of cases, the cause of acquired hemophilia is unknown.[2]