Mantle cell lymphoma laboratory findings: Difference between revisions

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Revision as of 18:14, 1 September 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Laboratory tests for mantle cell lymphoma include^[1]:

Heavy and light chain genes rearranged, t(11;14)(q13;q32) in virtually all cases
Overexpression CYCLIN D mRNA
Mutation or deletions of ATM gene

Polymerase chain reaction (PCR) and CER3 clonotypic primers are additional methods, but are less often used.

↑ National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov

@@ Line 5: / Line 5: @@
 ==Overview==
-Laboratory tests of mantle cell lymphoma include [[complete blood count]] (CBC) and blood chemistry studies.
+Laboratory tests for mantle cell lymphoma include [[complete blood count]] (CBC), blood chemistry studies, [[cytogenetic analysis]], [[flow cytometry]], [[immunohistochemistry]], [[genetic testing]], [[FISH]], [[PCR]], and [[Immunophenotyping]].
 ==Laboratory tests==
-Laboratory tests of mantle cell lymphoma include<ref name=”seer”>National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov</ref>:
+Laboratory tests for mantle cell lymphoma include<ref name=”seer”>National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov</ref>:
 * [[Complete blood count]] (CBC)
 * Blood chemistry studies
+* [[Cytogenetic analysis]]
+* [[Flow cytometry]]
+* Immunohistochemistry
+* [[Genetic Testing]]
+:* Heavy and light chain genes rearranged, t(11;14)(q13;q32) in virtually all cases
+:* Overexpression CYCLIN D [[mRNA]]
+:* Mutation or deletions of ''ATM gene''
+* [[FISH]] (fluorescence in situ hybridization)
+* [[PCR]]
+:*[[Polymerase chain reaction]] (PCR) and CER3 clonotypic primers are additional methods, but are less often used.
+* [[Immunophenotyping]]
+:*''BCL6-'', [[CD5]]+, [[CD10]]-, [[CD23]]- (or weakly positive), [[CD43]]+, FMC7+