Endometrial cancer classification: Difference between revisions
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==Overview== | ==Overview== | ||
Endometrial cancer may be classified according to histology into 7 subtypes: | Endometrial cancer may be classified according to histology into 7 subtypes: endometrioid, uterine papillary serous, mucinous, clear cell, squamous cell, mixed and undifferentiated. | ||
==Classification== | ==Classification== | ||
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'''Cellular Classification of Endometrial Cancer''' | '''Cellular Classification of Endometrial Cancer''' | ||
: 1. Endometrioid (75%–80%).[The most common endometrial cancer cell type is endometrioid adenocarcinoma, which is composed of malignant glandular epithelial elements] | : 1. Endometrioid (75%–80%).[The most common endometrial cancer cell type is endometrioid adenocarcinoma, which is composed of malignant glandular epithelial elements] | ||
::* Ciliated adenocarcinoma | ::* Ciliated adenocarcinoma | ||
::* Secretory adenocarcinoma | ::* Secretory adenocarcinoma | ||
::* Papillary or villoglandular | ::* Papillary or villoglandular | ||
::* Adenocarcinoma with squamous differentiation | ::* Adenocarcinoma with squamous differentiation | ||
:::* Adenoacanthoma | :::* Adenoacanthoma | ||
:::* Adenosquamous.[Adenosquamous tumors contain malignant elements of both glandular and squamous epithelium] | :::* Adenosquamous.[Adenosquamous tumors contain malignant elements of both glandular and squamous epithelium] | ||
: 2. Uterine papillary serous (<10%) | : 2. Uterine papillary serous (<10%) | ||
: 3. Mucinous (1%) | : 3. Mucinous (1%) | ||
: 4. Clear cell (4%) | : 4. Clear cell (4%) | ||
: 5. Squamous cell (<1%) | : 5. Squamous cell (<1%) | ||
: 6. Mixed (10%) | : 6. Mixed (10%) | ||
: 7. Undifferentiated | : 7. Undifferentiated | ||
Revision as of 14:11, 2 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Endometrial cancer may be classified according to histology into 7 subtypes: endometrioid, uterine papillary serous, mucinous, clear cell, squamous cell, mixed and undifferentiated.
Classification
- Endometrial cancers are classified in one of the following two categories:
- Type 1 may arise from complex atypical hyperplasia and is pathogenetically linked to unopposed estrogenic stimulation.
- Type 2 develops from atrophic endometrium and is not linked to hormonally driven pathogenesis.
Cellular Classification of Endometrial Cancer
- 1. Endometrioid (75%–80%).[The most common endometrial cancer cell type is endometrioid adenocarcinoma, which is composed of malignant glandular epithelial elements]
- Ciliated adenocarcinoma
- Secretory adenocarcinoma
- Papillary or villoglandular
- Adenocarcinoma with squamous differentiation
- Adenoacanthoma
- Adenosquamous.[Adenosquamous tumors contain malignant elements of both glandular and squamous epithelium]
- 2. Uterine papillary serous (<10%)
- 3. Mucinous (1%)
- 4. Clear cell (4%)
- 5. Squamous cell (<1%)
- 6. Mixed (10%)
- 7. Undifferentiated
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Endometrial stromal sarcoma
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Malignant mixed müllerian tumor
