Rhabdomyosarcoma laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
An elevated concentration of skeletal muscle protein '''myo D1''' is diagnostic of rhabdomyosarcoma. | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
When rhabdomyosarcoma is suspected, tests will be run for blood, muscle, and marrow. | When rhabdomyosarcoma is suspected, tests will be run for blood, muscle, and marrow. |
Revision as of 13:19, 9 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
An elevated concentration of skeletal muscle protein myo D1 is diagnostic of rhabdomyosarcoma.
Laboratory Findings
When rhabdomyosarcoma is suspected, tests will be run for blood, muscle, and marrow.
Immunohistochemical marker
- Diagnosis of rhabdomyosarcoma depends on recognition of differentiation toward skeletal muscle cells.
- The protein myo D1 is a immature protein normally found in developing skeletal muscle cells which disappears after the muscle matures and becomes innervated by a nerve.
- Thus, myo D1 is not found in normal skeletal muscle and serves as a useful immunohistochemical marker of rhabdomyosarcoma.