Esophageal cancer pathophysiology: Difference between revisions
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The pathophysiology of esophageal cancer depends on the histological subtype. | The pathophysiology of esophageal cancer depends on the histological subtype. | ||
== | ==Pathology== | ||
===Microscopic pathology=== | ===Microscopic pathology=== | ||
====Squamous cell carcinoma==== | ====Squamous cell carcinoma==== | ||
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====Adenocarcinoma==== | ====Adenocarcinoma==== | ||
*Invading | *Invading cell clusters or glands | ||
:*Cribriforming (more than rare) or desmoplasia or "deep" invasion (into submucosa) | :*Cribriforming (more than rare) or desmoplasia or "deep" invasion (into submucosa) | ||
*Nuclear atypia of malignancy: | *Nuclear atypia of malignancy: | ||
Revision as of 15:00, 9 September 2015
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Esophageal cancer Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Esophageal cancer pathophysiology On the Web |
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American Roentgen Ray Society Images of Esophageal cancer pathophysiology |
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Risk calculators and risk factors for Esophageal cancer pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
The pathophysiology of esophageal cancer depends on the histological subtype.
Pathology
Microscopic pathology
Squamous cell carcinoma
Atypical squamous cells with invasion through the basement membrane:
- Cytology:
- Nucleus - typical central
- +/-Mitoses
- Cytoplasm - "dense-appearing", typically eosinophilic (may be intensely eosinophilic)
- +/-Squamous whorls[1]
Adenocarcinoma
- Invading cell clusters or glands
- Cribriforming (more than rare) or desmoplasia or "deep" invasion (into submucosa)
- Nuclear atypia of malignancy:
- Size variation
- Shape variation
- Staining variation
- +/-Mitoses (common)[2]