Prolactinoma pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
==Associated Diseases== | ==Associated Diseases== | ||
[[Prolactinoma]] may occur as part of a hereditary disorder called multiple endocrine neoplasia type 1 (MEN 1). A minority of prolactinomas are associated with: | [[Prolactinoma]] may occur as part of a hereditary disorder called multiple endocrine neoplasia type 1 (MEN 1). A minority of prolactinomas are associated with:<ref>http://radiopaedia.org/articles/pituitary-adenoma</ref> | ||
*Multiple endocrine neoplasia type I (MEN I) | *Multiple endocrine neoplasia type I (MEN I) | ||
*Carney complex | *Carney complex | ||
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| [[Multiple endocrine neoplasia]] I | | [[Multiple endocrine neoplasia]] I | ||
| MEN1 | | MEN1 | ||
| characterized by the 3 Ps: '''p'''ituitary adenoma, [[parathyroid adenoma|'''p'''arathyroid adenoma]], | | characterized by the 3 Ps: '''p'''ituitary adenoma, [[parathyroid adenoma|'''p'''arathyroid adenoma]], '''p'''ancreatic neuroendocrine tumour | ||
|- | |- | ||
| MEN-1-like syndrome | | MEN-1-like syndrome | ||
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| Isolated pituitary adenoma<ref name=pmid22612670>{{Cite journal | last1 = Korbonits | first1 = M. | last2 = Storr | first2 = H. | last3 = Kumar | first3 = AV. | title = Familial pituitary adenomas - Who should be tested for AIP mutations? | journal = Clin Endocrinol (Oxf) | volume = | issue = | pages = | month = May | year = 2012 | doi = 10.1111/j.1365-2265.2012.04445.x | PMID = 22612670 }}</ref> | | Isolated pituitary adenoma<ref name=pmid22612670>{{Cite journal | last1 = Korbonits | first1 = M. | last2 = Storr | first2 = H. | last3 = Kumar | first3 = AV. | title = Familial pituitary adenomas - Who should be tested for AIP mutations? | journal = Clin Endocrinol (Oxf) | volume = | issue = | pages = | month = May | year = 2012 | doi = 10.1111/j.1365-2265.2012.04445.x | PMID = 22612670 }}</ref> | ||
| AIP | | AIP | ||
| classically | | classically growth hormone-producing adenoma - leads to acromegaly | ||
|} | |} | ||
Revision as of 18:07, 10 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]
Overview
Prolactinoma may occur as part of a hereditary disorder called multiple endocrine neoplasia type 1 (MEN 1). A minority of prolactinomas are associated with Carney complex, McCune-Albright Syndrome, MEN like syndrome (CKDN1B loss of function).[1]
Pathophysiology
Associated Diseases
Prolactinoma may occur as part of a hereditary disorder called multiple endocrine neoplasia type 1 (MEN 1). A minority of prolactinomas are associated with:[2]
- Multiple endocrine neoplasia type I (MEN I)
- Carney complex
- McCune-Albright Syndrome
- MEN like syndrome ( CKDN1B loss of function)[3]
Familial pituitary adenomas
A pituitary adenoma may be part of a familial syndrome:[4][5]
| Syndrome | Gene | Notes |
|---|---|---|
| Multiple endocrine neoplasia I | MEN1 | characterized by the 3 Ps: pituitary adenoma, parathyroid adenoma, pancreatic neuroendocrine tumour |
| MEN-1-like syndrome | CDKN1B[6] | also known as Multiple endocrine neoplasia IV [6] |
| Carney syndrome | PRKAR1A | other findings (mnemonic NAME): nevi, atrial myxoma, myxoid neurofibroma, ephelides (freckles) |
| Isolated pituitary adenoma[7] | AIP | classically growth hormone-producing adenoma - leads to acromegaly |
Microscopic Pathology
Features:[8]
- Loss of fibrous stroma
- The cells of a normal (anterior) pituitary are nested
Notes:
- Smears very well.[9]
Stains
- Reticulin - loss of reticulin between tumour cells
References
- ↑ http://radiopaedia.org/articles/pituitary-adenoma
- ↑ http://radiopaedia.org/articles/pituitary-adenoma
- ↑ http://radiopaedia.org/articles/pituitary-adenoma
- ↑ Elston, MS.; McDonald, KL.; Clifton-Bligh, RJ.; Robinson, BG. (2009). "Familial pituitary tumor syndromes". Nat Rev Endocrinol. 5 (8): 453–61. doi:10.1038/nrendo.2009.126. PMID 19564887. Unknown parameter
|month=ignored (help) - ↑ Template:Ref PCPBoD8
- ↑ 6.0 6.1 Online Mendelian Inheritance in Man (OMIM) 600778
- ↑ Korbonits, M.; Storr, H.; Kumar, AV. (2012). "Familial pituitary adenomas - Who should be tested for AIP mutations?". Clin Endocrinol (Oxf). doi:10.1111/j.1365-2265.2012.04445.x. PMID 22612670. Unknown parameter
|month=ignored (help) - ↑ Template:Ref PSNP
- ↑ MUN. 24 November 2010.