Prolactinoma causes: Difference between revisions
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==Causes== | ==Causes== | ||
There are no established causes for prolactinoma. Most pituitary tumors are | There are no established causes for prolactinoma. Most pituitary tumors are sporadic. A minority of prolactinomas are associated with [[familial]] syndromes. | ||
===Familial Causes=== | ===Familial Causes=== | ||
Revision as of 14:29, 11 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]
Overview
There are no established causes for prolactinoma. Most pituitary tumors are sporadic.
Causes
There are no established causes for prolactinoma. Most pituitary tumors are sporadic. A minority of prolactinomas are associated with familial syndromes.
Familial Causes
Prolactinoma may occur as part of a hereditary disorder called multiple endocrine neoplasia type 1 (MEN 1). A minority of prolactinomas are associated with:[1]
- Multiple endocrine neoplasia type 1 (MEN I)
- Carney complex
- McCune-Albright Syndrome
- MEN like syndrome (CKDN1B loss of function)
Other Causes
Other causes include:
- The xenoestrogenic chemical Bisphenol-A has been shown to lead to hyperprolactinaemia and growth of prolactin-producing pituitary cells.[2] The increasing and prolonged exposure of Bisphenol-A from childhood may contribute to the growth of a prolactinoma.
References
- ↑ http://radiopaedia.org/articles/pituitary-adenoma
- ↑ ^ Goloubkova T, Ribeiro MF, Rodrigues LP, Cecconello AL, Spritzer PM (April 2000). "Effects of xenoestrogen bisphenol A on uterine and pituitary weight, serum prolactin levels and immunoreactive prolactin cells in ovariectomized Wistar rats". Arch. Toxicol. 74 (2): 92–8. doi:10.1007/s002040050658. PMID 10839476