Glioblastoma multiforme natural history: Difference between revisions
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==Prognosis== | ==Prognosis== | ||
*Depending on the extent of glioblastoma at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor. | |||
* | *Negative prognostic factors include:<ref name=ddd>Prognosis of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref> | ||
**Degree of necrosis | |||
* With standard treatment ([[radiotherapy]], [[chemotherapy]] (such as [[temozolomide]]), and [[surgery]]), the | **Degree of enhancement | ||
**Deep location (e.g. thalamus) | |||
* | *Median survival time from the time of diagnosis without any treatment is 3 months. Increasing age (> 60 years of age) carries a worse prognostic risk. | ||
*With standard treatment ([[radiotherapy]], [[chemotherapy]] (such as [[temozolomide]]), and [[surgery]]), the median survival is approximately 14 months.<ref>{{cite journal | author = Stupp R, Mason W, van den Bent M, Weller M, Fisher B, Taphoorn M, Belanger K, Brandes A, Marosi C, Bogdahn U, Curschmann J, Janzer R, Ludwin S, Gorlia T, Allgeier A, Lacombe D, Cairncross J, Eisenhauer E, Mirimanoff R | title = Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. | journal = N Engl J Med | volume = 352 | issue = 10 | pages = 987-96 | year = 2005 | id = PMID 15758009}}</ref> Less than 10% of these patients survive past 5 years. | |||
*Study published in 2007 reported the 2-year survival at 27.3%, 3-year survival 16.7% and 4 year survival 12.9%.<ref>R. Mirimanoff , W. Mason , M. Van den Bent , R. Kortmann , M. Taphoorn , A. Brandes , S. Villa , G. Cairncrosss , T. Gorlia , R. Stupp | |||
International Journal of Radiation Oncology * Biology * Physics- November 2007 1 (Vol. 69, Issue 3, Page S2, DOI: 10.1016/j.ijrobp.2007.07.004) | International Journal of Radiation Oncology * Biology * Physics- November 2007 1 (Vol. 69, Issue 3, Page S2, DOI: 10.1016/j.ijrobp.2007.07.004) | ||
[http://www.redjournal.org/article/PIIS036030160701187X/fulltext]</ref> | [http://www.redjournal.org/article/PIIS036030160701187X/fulltext]</ref> | ||
==References== | ==References== | ||
Revision as of 19:52, 14 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [3]
Overview
Natural History
Complications
Common complications of glioblastoma include:[1]
- Herniation (axial, transtentorial, subfalcine, tonsillar)
- Systemic illness
- Dysphagia
- Aphasia
- Brainstem invasion by tumor
- Neutron-induced cerebral injury
- Weakness
- Fatigue
- Numbness
- Surgical complications (cerebral hemorrhage, edema)
- Coma
Prognosis
- Depending on the extent of glioblastoma at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor.
- Negative prognostic factors include:[2]
- Degree of necrosis
- Degree of enhancement
- Deep location (e.g. thalamus)
- Median survival time from the time of diagnosis without any treatment is 3 months. Increasing age (> 60 years of age) carries a worse prognostic risk.
- With standard treatment (radiotherapy, chemotherapy (such as temozolomide), and surgery), the median survival is approximately 14 months.[3] Less than 10% of these patients survive past 5 years.
- Study published in 2007 reported the 2-year survival at 27.3%, 3-year survival 16.7% and 4 year survival 12.9%.[4]
References
- ↑ Silbergeld DL, Rostomily RC, Alvord EC (1991). "The cause of death in patients with glioblastoma is multifactorial: clinical factors and autopsy findings in 117 cases of supratentorial glioblastoma in adults". J Neurooncol. 10 (2): 179–85. PMID 1654403.
- ↑ Prognosis of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma
- ↑ Stupp R, Mason W, van den Bent M, Weller M, Fisher B, Taphoorn M, Belanger K, Brandes A, Marosi C, Bogdahn U, Curschmann J, Janzer R, Ludwin S, Gorlia T, Allgeier A, Lacombe D, Cairncross J, Eisenhauer E, Mirimanoff R (2005). "Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma". N Engl J Med. 352 (10): 987–96. PMID 15758009.
- ↑ R. Mirimanoff , W. Mason , M. Van den Bent , R. Kortmann , M. Taphoorn , A. Brandes , S. Villa , G. Cairncrosss , T. Gorlia , R. Stupp International Journal of Radiation Oncology * Biology * Physics- November 2007 1 (Vol. 69, Issue 3, Page S2, DOI: 10.1016/j.ijrobp.2007.07.004) [1]