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{{Nasopharyngeal carcinoma}}
{{Nasopharyngeal carcinoma}}
{{CMG}} {{AE}}{{Faizan}}
{{CMG}} {{AE}}{{Faizan}}
==Pathophysiology==
==Gross==
**Nasal cavity involvement - common in early disease.<ref name=pmid22194474 >{{Cite journal  | last1 = Abdel Khalek Abdel Razek | first1 = A. | last2 = King | first2 = A. | title = MRI and CT of nasopharyngeal carcinoma. | journal = AJR Am J Roentgenol | volume = 198 | issue = 1 | pages = 11-8 | month = Jan | year = 2012 | doi = 10.2214/AJR.11.6954 | PMID = 22194474 }}</ref>
==Microscopic==
Features:<ref name=Ref_Klatt145>{{Ref Klatt|145}}</ref>
*Prominent lymphoid component - '''key feature'''.
*Features of squamous cell carcinoma:
**Cohesive cells with:
***Abundant dense eosinophilic cytoplasm.
***Central nuclei +/- small/indistinct nucleoli.
===Images===
<gallery>
Image:Lymphoepithelioma_met_to_LN_6.jpg | Nasopharyngeal carcinoma - in a LN - intermed. mag. (WC)
</gallery>
www:
*[http://en.wikipedia.org/wiki/File:Lymphoepithelioma_met_to_LN_4.jpg Nasopharyngeal carcinoma - in a LN - low mag. (WP)].
*[http://en.wikipedia.org/wiki/File:Lymphoepithelioma_met_to_LN_2.jpg Nasopharyngeal carcinoma - in a LN - high mag. (WP)].
===Histologic subclassification===
World Health Classification (2005) for NPC:<ref name=Ref_WMSP39>{{Ref WMSP|39}}</ref>
{| class="wikitable"
! Type
! Histology
! Description
! EBV
! Prevalence
! Prognosis
|-
| 1
| keratinizing SCC
| graded poorly-well-diff.
| -ve
| ?
| bad
|-
| 2a
| nonkeratinizing carcinoma, differentiated
| well def. cell borders & tumour nest borders, mimics appearance of [[UCC]]
| +ve
| ?
| good
|-
| 2b
| nonkeratinizing carcinoma, undifferentiated
| sheets/syncytial, vescicular nuclei, prominent nucleoli, pink cytoplasm
| ?
| most common
| ?
|-
| 3
| basaloid SCC
| mimics BCC - see [[basaloid SCC]]
| ?
| least common
| ?
|}
==Immunohistochemistry==
*EBER +ve.
*p16 -ve.<ref name=pmid9546345>{{cite journal |author=Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY, Geradts J |title=Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product |journal=Am. J. Pathol. |volume=152 |issue=4 |pages=865–9 |year=1998 |month=April |pmid=9546345 |pmc=1858242 |doi= |url=}}</ref>
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}

Revision as of 14:36, 16 September 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]

Pathophysiology

Gross

    • Nasal cavity involvement - common in early disease.[1]

Microscopic

Features:[2]

  • Prominent lymphoid component - key feature.
  • Features of squamous cell carcinoma:
    • Cohesive cells with:
      • Abundant dense eosinophilic cytoplasm.
      • Central nuclei +/- small/indistinct nucleoli.

Images

  • Nasopharyngeal carcinoma - in a LN - intermed. mag. (WC)
    Nasopharyngeal carcinoma - in a LN - intermed. mag. (WC)

www:

Histologic subclassification

World Health Classification (2005) for NPC:[3]

Type Histology Description EBV Prevalence Prognosis
1 keratinizing SCC graded poorly-well-diff. -ve ? bad
2a nonkeratinizing carcinoma, differentiated well def. cell borders & tumour nest borders, mimics appearance of UCC +ve ? good
2b nonkeratinizing carcinoma, undifferentiated sheets/syncytial, vescicular nuclei, prominent nucleoli, pink cytoplasm ? most common ?
3 basaloid SCC mimics BCC - see basaloid SCC ? least common ?

Immunohistochemistry

  • EBER +ve.
  • p16 -ve.[4]

References

  1. ↑ Abdel Khalek Abdel Razek, A.; King, A. (2012). "MRI and CT of nasopharyngeal carcinoma". AJR Am J Roentgenol. 198 (1): 11–8. doi:10.2214/AJR.11.6954. PMID 22194474. Unknown parameter |month= ignored (help)
  2. ↑ Template:Ref Klatt
  3. ↑ Template:Ref WMSP
  4. ↑ Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY, Geradts J (1998). "Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product". Am. J. Pathol. 152 (4): 865–9. PMC 1858242. PMID 9546345. Unknown parameter |month= ignored (help)


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