Nasopharyngeal carcinoma pathophysiology: Difference between revisions
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{{Nasopharyngeal carcinoma}} | {{Nasopharyngeal carcinoma}} | ||
{{CMG}} {{AE}}{{Faizan}} | {{CMG}} {{AE}}{{Faizan}} | ||
==Pathophysiology== | ==Pathophysiology== | ||
==Gross== | ==Gross== | ||
*Nasal cavity involvement - common in early disease.<ref name=pmid22194474 >{{Cite journal | last1 = Abdel Khalek Abdel Razek | first1 = A. | last2 = King | first2 = A. | title = MRI and CT of nasopharyngeal carcinoma. | journal = AJR Am J Roentgenol | volume = 198 | issue = 1 | pages = 11-8 | month = Jan | year = 2012 | doi = 10.2214/AJR.11.6954 | PMID = 22194474 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=Ref_Klatt145>{{Ref Klatt|145}}</ref> | Features:<ref name=Ref_Klatt145>{{Ref Klatt|145}}</ref> | ||
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*[http://en.wikipedia.org/wiki/File:Lymphoepithelioma_met_to_LN_4.jpg Nasopharyngeal carcinoma - in a LN - low mag. (WP)]. | *[http://en.wikipedia.org/wiki/File:Lymphoepithelioma_met_to_LN_4.jpg Nasopharyngeal carcinoma - in a LN - low mag. (WP)]. | ||
*[http://en.wikipedia.org/wiki/File:Lymphoepithelioma_met_to_LN_2.jpg Nasopharyngeal carcinoma - in a LN - high mag. (WP)]. | *[http://en.wikipedia.org/wiki/File:Lymphoepithelioma_met_to_LN_2.jpg Nasopharyngeal carcinoma - in a LN - high mag. (WP)]. | ||
===Histologic subclassification=== | ===Histologic subclassification=== | ||
World Health Classification (2005) for NPC:<ref name=Ref_WMSP39>{{Ref WMSP|39}}</ref> | World Health Classification (2005) for NPC:<ref name=Ref_WMSP39>{{Ref WMSP|39}}</ref> | ||
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==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
Revision as of 14:38, 16 September 2015
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Nasopharyngeal carcinoma Microchapters |
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Differentiating Nasopharyngeal carcinoma from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Nasopharyngeal carcinoma pathophysiology On the Web |
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American Roentgen Ray Society Images of Nasopharyngeal carcinoma pathophysiology |
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Risk calculators and risk factors for Nasopharyngeal carcinoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]
Pathophysiology
Gross
- Nasal cavity involvement - common in early disease.[1]
Microscopic
Features:[2]
- Prominent lymphoid component - key feature.
- Features of squamous cell carcinoma:
- Cohesive cells with:
- Abundant dense eosinophilic cytoplasm.
- Central nuclei +/- small/indistinct nucleoli.
- Cohesive cells with:
Images
-
Nasopharyngeal carcinoma - in a LN - intermed. mag. (WC)
www:
- Nasopharyngeal carcinoma - in a LN - low mag. (WP).
- Nasopharyngeal carcinoma - in a LN - high mag. (WP).
Histologic subclassification
World Health Classification (2005) for NPC:[3]
| Type | Histology | Description | EBV | Prevalence | Prognosis |
|---|---|---|---|---|---|
| 1 | keratinizing SCC | graded poorly-well-diff. | -ve | ? | bad |
| 2a | nonkeratinizing carcinoma, differentiated | well def. cell borders & tumour nest borders, mimics appearance of UCC | +ve | ? | good |
| 2b | nonkeratinizing carcinoma, undifferentiated | sheets/syncytial, vescicular nuclei, prominent nucleoli, pink cytoplasm | ? | most common | ? |
| 3 | basaloid SCC | mimics BCC - see basaloid SCC | ? | least common | ? |
Immunohistochemistry
- EBER +ve.
- p16 -ve.[4]
References
- ↑ Abdel Khalek Abdel Razek, A.; King, A. (2012). "MRI and CT of nasopharyngeal carcinoma". AJR Am J Roentgenol. 198 (1): 11–8. doi:10.2214/AJR.11.6954. PMID 22194474. Unknown parameter
|month=ignored (help) - ↑ Template:Ref Klatt
- ↑ Template:Ref WMSP
- ↑ Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY, Geradts J (1998). "Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product". Am. J. Pathol. 152 (4): 865–9. PMC 1858242. PMID 9546345. Unknown parameter
|month=ignored (help)