Nasopharyngeal carcinoma pathophysiology: Difference between revisions

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*Nasal cavity involvement - common in early disease.<ref name=pmid22194474 >{{Cite journal  | last1 = Abdel Khalek Abdel Razek | first1 = A. | last2 = King | first2 = A. | title = MRI and CT of nasopharyngeal carcinoma. | journal = AJR Am J Roentgenol | volume = 198 | issue = 1 | pages = 11-8 | month = Jan | year = 2012 | doi = 10.2214/AJR.11.6954 | PMID = 22194474 }}</ref>
*Nasal cavity involvement - common in early disease.<ref name=pmid22194474 >{{Cite journal  | last1 = Abdel Khalek Abdel Razek | first1 = A. | last2 = King | first2 = A. | title = MRI and CT of nasopharyngeal carcinoma. | journal = AJR Am J Roentgenol | volume = 198 | issue = 1 | pages = 11-8 | month = Jan | year = 2012 | doi = 10.2214/AJR.11.6954 | PMID = 22194474 }}</ref>
==Microscopic==
==Microscopic==
Features:<ref name=Ref_Klatt145>{{Ref Klatt|145}}</ref>
Features:<ref name= Librepathology>Nasopharyngeal carcinoma http://librepathology.org/wiki/index.php/Nasopharyngeal_carcinoma</ref>
*Prominent lymphoid component - '''key feature'''.
*Prominent lymphoid component - '''key feature'''.
*Features of squamous cell carcinoma:
*Features of squamous cell carcinoma:
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***Abundant dense eosinophilic cytoplasm.
***Abundant dense eosinophilic cytoplasm.
***Central nuclei +/- small/indistinct nucleoli.
***Central nuclei +/- small/indistinct nucleoli.
===Images===
<gallery>
<gallery>
Image:Lymphoepithelioma_met_to_LN_6.jpg | Nasopharyngeal carcinoma - in a LN - intermed. mag. (WC)
Image:Lymphoepithelioma_met_to_LN_6.jpg | Nasopharyngeal carcinoma
</gallery>
</gallery>
www:
*[http://en.wikipedia.org/wiki/File:Lymphoepithelioma_met_to_LN_4.jpg Nasopharyngeal carcinoma - in a LN - low mag. (WP)].
*[http://en.wikipedia.org/wiki/File:Lymphoepithelioma_met_to_LN_2.jpg Nasopharyngeal carcinoma - in a LN - high mag. (WP)].
===Histologic subclassification===
===Histologic subclassification===
World Health Classification (2005) for NPC:<ref name=Ref_WMSP39>{{Ref WMSP|39}}</ref>
World Health Classification (2005) for NPC:<ref name= Librepathology>Nasopharyngeal carcinoma http://librepathology.org/wiki/index.php/Nasopharyngeal_carcinoma</ref>
{| class="wikitable"
{| class="wikitable"
! Type
! Type
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| 2a
| 2a
| nonkeratinizing carcinoma, differentiated
| nonkeratinizing carcinoma, differentiated
| well def. cell borders & tumour nest borders, mimics appearance of [[UCC]]
| well def. cell borders & tumour nest borders, mimics appearance of UCC
| +ve
| +ve
| ?
| ?
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| 3
| 3
| basaloid SCC
| basaloid SCC
| mimics BCC - see [[basaloid SCC]]
| mimics BCC - see basaloid SCC
| ?
| ?
| least common
| least common

Revision as of 14:51, 16 September 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]

Pathophysiology

Gross

  • Nasal cavity involvement - common in early disease.[1]

Microscopic

Features:[2]

  • Prominent lymphoid component - key feature.
  • Features of squamous cell carcinoma:
    • Cohesive cells with:
      • Abundant dense eosinophilic cytoplasm.
      • Central nuclei +/- small/indistinct nucleoli.
  • Nasopharyngeal carcinoma
    Nasopharyngeal carcinoma

Histologic subclassification

World Health Classification (2005) for NPC:[2]

Type Histology Description EBV Prevalence Prognosis
1 keratinizing SCC graded poorly-well-diff. -ve ? bad
2a nonkeratinizing carcinoma, differentiated well def. cell borders & tumour nest borders, mimics appearance of UCC +ve ? good
2b nonkeratinizing carcinoma, undifferentiated sheets/syncytial, vescicular nuclei, prominent nucleoli, pink cytoplasm ? most common ?
3 basaloid SCC mimics BCC - see basaloid SCC ? least common ?

Immunohistochemistry

  • EBER +ve.
  • p16 -ve.[3]

References

  1. ↑ Abdel Khalek Abdel Razek, A.; King, A. (2012). "MRI and CT of nasopharyngeal carcinoma". AJR Am J Roentgenol. 198 (1): 11–8. doi:10.2214/AJR.11.6954. PMID 22194474. Unknown parameter |month= ignored (help)
  2. ↑ 2.0 2.1 Nasopharyngeal carcinoma http://librepathology.org/wiki/index.php/Nasopharyngeal_carcinoma
  3. ↑ Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY, Geradts J (1998). "Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product". Am. J. Pathol. 152 (4): 865–9. PMC 1858242. PMID 9546345. Unknown parameter |month= ignored (help)

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