Nasopharyngeal carcinoma pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
==Gross== | ==Gross== | ||
*Nasal cavity involvement - common in early disease | *Nasal cavity involvement - common in early disease<ref name=pmid22194474 >{{Cite journal | last1 = Abdel Khalek Abdel Razek | first1 = A. | last2 = King | first2 = A. | title = MRI and CT of nasopharyngeal carcinoma. | journal = AJR Am J Roentgenol | volume = 198 | issue = 1 | pages = 11-8 | month = Jan | year = 2012 | doi = 10.2214/AJR.11.6954 | PMID = 22194474 }}</ref> | ||
==Microscopic== | ==Microscopic== | ||
Features:<ref name= Librepathology>Nasopharyngeal carcinoma http://librepathology.org/wiki/index.php/Nasopharyngeal_carcinoma</ref> | Features:<ref name= Librepathology>Nasopharyngeal carcinoma http://librepathology.org/wiki/index.php/Nasopharyngeal_carcinoma</ref> | ||
*Prominent lymphoid component - '''key feature''' | *Prominent lymphoid component - '''key feature''' | ||
*Features of squamous cell carcinoma: | *Features of squamous cell carcinoma: | ||
**Cohesive cells with: | **Cohesive cells with: | ||
***Abundant dense eosinophilic cytoplasm | ***Abundant dense eosinophilic cytoplasm | ||
***Central nuclei +/- small/indistinct nucleoli | ***Central nuclei +/- small/indistinct nucleoli | ||
[[Image:Lymphoepithelioma_met_to_LN_6.jpg |thumb|none|250px| Nasopharyngeal carcinoma]] | [[Image:Lymphoepithelioma_met_to_LN_6.jpg |thumb|none|250px| Nasopharyngeal carcinoma]] | ||
===Histologic subclassification=== | ===Histologic subclassification=== | ||
| Line 54: | Line 54: | ||
|} | |} | ||
==Immunohistochemistry== | ==Immunohistochemistry== | ||
*EBER +ve | *EBER +ve | ||
*p16 -ve | *p16 -ve<ref name=pmid9546345>{{cite journal |author=Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY, Geradts J |title=Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product |journal=Am. J. Pathol. |volume=152 |issue=4 |pages=865–9 |year=1998 |month=April |pmid=9546345 |pmc=1858242 |doi= |url=}}</ref> | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 15:25, 16 September 2015
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Nasopharyngeal carcinoma Microchapters |
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Differentiating Nasopharyngeal carcinoma from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Nasopharyngeal carcinoma pathophysiology On the Web |
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American Roentgen Ray Society Images of Nasopharyngeal carcinoma pathophysiology |
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Risk calculators and risk factors for Nasopharyngeal carcinoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]
Overview
On microscopic histopathological analysis, abundant dense eosinophilic cytoplasm and prominent lymphoid component are characteristic findings of nasopharyngeal carcinoma.
Pathophysiology
Gross
- Nasal cavity involvement - common in early disease[1]
Microscopic
Features:[2]
- Prominent lymphoid component - key feature
- Features of squamous cell carcinoma:
- Cohesive cells with:
- Abundant dense eosinophilic cytoplasm
- Central nuclei +/- small/indistinct nucleoli
- Cohesive cells with:
Histologic subclassification
World Health Classification (2005) for NPC:[2]
| Type | Histology | Description | EBV | Prevalence | Prognosis |
|---|---|---|---|---|---|
| 1 | Keratinizing SCC | graded poorly-well-diff. | -ve | bad | |
| 2a | Nonkeratinizing carcinoma, differentiated | well defined cell borders & tumour nest borders | +ve | good | |
| 2b | Nonkeratinizing carcinoma, undifferentiated | sheets/syncytial, vescicular nuclei, prominent nucleoli, pink cytoplasm | most common | ||
| 3 | Basaloid SCC | mimics basal cell carcinoma | least common |
Immunohistochemistry
- EBER +ve
- p16 -ve[3]
References
- ↑ Abdel Khalek Abdel Razek, A.; King, A. (2012). "MRI and CT of nasopharyngeal carcinoma". AJR Am J Roentgenol. 198 (1): 11–8. doi:10.2214/AJR.11.6954. PMID 22194474. Unknown parameter
|month=ignored (help) - ↑ 2.0 2.1 Nasopharyngeal carcinoma http://librepathology.org/wiki/index.php/Nasopharyngeal_carcinoma
- ↑ Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY, Geradts J (1998). "Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product". Am. J. Pathol. 152 (4): 865–9. PMC 1858242. PMID 9546345. Unknown parameter
|month=ignored (help)