Rhabdomyosarcoma natural history, complications and prognosis: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Rhabdomyosarcoma}} | {{Rhabdomyosarcoma}} | ||
{{CMG}};{{AE}} {{ | {{CMG}};{{AE}} {{S.M}} | ||
==Overview== | ==Overview== | ||
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==Complications== | ==Complications== | ||
*Rhabdomyosarcoma may cause [[metastasis]] to other organs. | * Rhabdomyosarcoma may cause [[metastasis]] to other organs.<ref name="pmid2843274">{{cite journal| author=Raney RB, Tefft M, Maurer HM, Ragab AH, Hays DM, Soule EH et al.| title=Disease patterns and survival rate in children with metastatic soft-tissue sarcoma. A report from the Intergroup Rhabdomyosarcoma Study (IRS)-I. | journal=Cancer | year= 1988 | volume= 62 | issue= 7 | pages= 1257-66 | pmid=2843274 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2843274 }} </ref> | ||
*The | ** Less than 25% of patients present with distant metastases at he time of diagnosis.<ref name="pmid1574030">{{cite journal| author=Koscielniak E, Rodary C, Flamant F, Carli M, Treuner J, Pinkerton CR et al.| title=Metastatic rhabdomyosarcoma and histologically similar tumors in childhood: a retrospective European multi-center analysis. | journal=Med Pediatr Oncol | year= 1992 | volume= 20 | issue= 3 | pages= 209-14 | pmid=1574030 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1574030 }} </ref> | ||
* | ** The common metastatic site is lung. | ||
** The other metastatic sites are as following:<ref name="pmid6546301">{{cite journal| author=Ruymann FB, Newton WA, Ragab AH, Donaldson MH, Foulkes M| title=Bone marrow metastases at diagnosis in children and adolescents with rhabdomyosarcoma. A report from the intergroup rhabdomyosarcoma study. | journal=Cancer | year= 1984 | volume= 53 | issue= 2 | pages= 368-73 | pmid=6546301 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6546301 }} </ref><ref name="pmid12506174">{{cite journal| author=Breneman JC, Lyden E, Pappo AS, Link MP, Anderson JR, Parham DM et al.| title=Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma--a report from the Intergroup Rhabdomyosarcoma Study IV. | journal=J Clin Oncol | year= 2003 | volume= 21 | issue= 1 | pages= 78-84 | pmid=12506174 | doi=10.1200/JCO.2003.06.129 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12506174 }} </ref> | |||
*** Bone marrow (30%) | |||
*** Bone (30%) | |||
*** Omentum and ascites (16%) | |||
*** Pleura (13%) | |||
*** Visceral involvement | |||
*** brain metastases | |||
==Prognosis== | ==Prognosis== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Shadan Mehraban, M.D.[2]
Overview
Common complications of rhabdomyosarcoma include metastasis to lung, bone marrow, and bone. Rhabdomyosarcoma is associated with a 5 year survival rate of 72%. The presence of metastasis is associated with a particularly poor prognosis. Histologically, the embryonal type rhabdomyosarcoma and anatomically, the orbital and genitourinary tract rhabdomyosarcomas have the most favorable prognosis.
Complications
- Rhabdomyosarcoma may cause metastasis to other organs.[1]
Prognosis
- Rhabdomyosarcoma is associated with a 5 year survival rate of 72%.
- The presence of metastasis is associated with a particularly poor prognosis among patients with rhabdomyosarcoma. The 5 year event free survival rate is less than 30%.
- Histologically, the embryonal type rhabdomyosarcoma and anatomically, the orbital and genitourinary tract rhabdomyosarcomas have the most favorable prognosis.
References
- ↑ Raney RB, Tefft M, Maurer HM, Ragab AH, Hays DM, Soule EH; et al. (1988). "Disease patterns and survival rate in children with metastatic soft-tissue sarcoma. A report from the Intergroup Rhabdomyosarcoma Study (IRS)-I". Cancer. 62 (7): 1257–66. PMID 2843274.
- ↑ Koscielniak E, Rodary C, Flamant F, Carli M, Treuner J, Pinkerton CR; et al. (1992). "Metastatic rhabdomyosarcoma and histologically similar tumors in childhood: a retrospective European multi-center analysis". Med Pediatr Oncol. 20 (3): 209–14. PMID 1574030.
- ↑ Ruymann FB, Newton WA, Ragab AH, Donaldson MH, Foulkes M (1984). "Bone marrow metastases at diagnosis in children and adolescents with rhabdomyosarcoma. A report from the intergroup rhabdomyosarcoma study". Cancer. 53 (2): 368–73. PMID 6546301.
- ↑ Breneman JC, Lyden E, Pappo AS, Link MP, Anderson JR, Parham DM; et al. (2003). "Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma--a report from the Intergroup Rhabdomyosarcoma Study IV". J Clin Oncol. 21 (1): 78–84. doi:10.1200/JCO.2003.06.129. PMID 12506174.