Glioblastoma multiforme surgery: Difference between revisions
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==Surgery== | ==Surgery== | ||
'''1. Surgery''' is the mainstay of treatment for glioblastoma multiforme.<ref name=ddd>Treatment of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref> | |||
*The aim of surgery is to: | |||
**Make a definitive diagnosis | |||
**Debulk the tumor to relieve elevated intracranial pressure | |||
**Reduce the tumor mass as a precursor to adjuvant treatment | |||
'''2. CSF shunting''' is performed to relieve the pressure in the brain due to blockade in the flow of cerebrospinal fluid by the tumor. | |||
*External ventricular drain | |||
**Temporary shunt | |||
*Internal drain | |||
**Permanent shunt | |||
**Drains CSF into the patient’s abdomen, where it is absorbed into the body | |||
[[Surgery]] is the mainstay of treatment for glioblastoma multiforme. | |||
*An average glioblastoma multiforme [[tumor]] contains 10<sup>11</sup> cells, which is reduced to 10<sup>9</sup> cells after surgery (a reduction of 99%). | *An average glioblastoma multiforme [[tumor]] contains 10<sup>11</sup> cells, which is reduced to 10<sup>9</sup> cells after surgery (a reduction of 99%). | ||
*Surgery is used to take a section for a [[pathology|pathological diagnosis]], to remove the symptoms of a large mass pressing against the [[brain]], to remove [[tumor]] before secondary resistance to [[radiotherapy]] and [[chemotherapy]], and to prolong survival. | *Surgery is used to take a section for a [[pathology|pathological diagnosis]], to remove the symptoms of a large mass pressing against the [[brain]], to remove [[tumor]] before secondary resistance to [[radiotherapy]] and [[chemotherapy]], and to prolong survival. | ||
Revision as of 18:38, 28 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Surgery is the mainstay of treatment for glioblastoma multiforme.[1]
Surgery
1. Surgery is the mainstay of treatment for glioblastoma multiforme.[1]
- The aim of surgery is to:
- Make a definitive diagnosis
- Debulk the tumor to relieve elevated intracranial pressure
- Reduce the tumor mass as a precursor to adjuvant treatment
2. CSF shunting is performed to relieve the pressure in the brain due to blockade in the flow of cerebrospinal fluid by the tumor.
- External ventricular drain
- Temporary shunt
- Internal drain
- Permanent shunt
- Drains CSF into the patient’s abdomen, where it is absorbed into the body
Surgery is the mainstay of treatment for glioblastoma multiforme.
- An average glioblastoma multiforme tumor contains 1011 cells, which is reduced to 109 cells after surgery (a reduction of 99%).
- Surgery is used to take a section for a pathological diagnosis, to remove the symptoms of a large mass pressing against the brain, to remove tumor before secondary resistance to radiotherapy and chemotherapy, and to prolong survival.
- Removal of 98% or more of the tumor has been associated with a better prognosis.
- The chances of near-complete initial removal of the tumor can be greatly increased if the surgery is guided by a fluorescent dye known as 5-aminolevulinic acid.
- Glioblastoma multiforme tumor cells are widely infiltrative through the brain at diagnosis. Despite a near-total resection, majority of people with glioblastoma multiforme develop recurrence, either at the original site or at distant satellite lesions within the brain.
References
- ↑ 1.0 1.1 Treatment of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma