Nasopharyngeal carcinoma natural history, complications and prognosis: Difference between revisions
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*[[Atrophy]] and fibrosis of the [[muscles of mastication]] | *[[Atrophy]] and fibrosis of the [[muscles of mastication]] | ||
==Prognosis== | ==Prognosis== | ||
Non-keratinizing nasopharyngeal carcinoma is associated with a 5 year survival rate of 65%.<ref name="Weidner's">{{cite book |author=Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor) |title=Modern Surgical Pathology (2 Volume Set) |publisher=W B Saunders |location=London |year= |pages= |isbn=0-7216-7253-1 |oclc= |doi=}}</ref> Prognosis is influenced | Non-keratinizing nasopharyngeal carcinoma is associated with a 5 year survival rate of 65%.<ref name="Weidner's">{{cite book |author=Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor) |title=Modern Surgical Pathology (2 Volume Set) |publisher=W B Saunders |location=London |year= |pages= |isbn=0-7216-7253-1 |oclc= |doi=}}</ref> Prognosis is influenced by tumor type: | ||
*Type I: Keratinizing [[squamous]] cell carcinoma - 42% 5 year survival | *Type I: Keratinizing [[squamous]] cell carcinoma - 42% 5 year survival | ||
*Type II: Non-keratinizing squamous cell [[carcinoma]] - 65% 5 year survival | *Type II: Non-keratinizing squamous cell [[carcinoma]] - 65% 5 year survival |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]
Overview
If left untreated nasopharyngeal carcinoma produces few symptoms early in the course of disease. Non-keratinizing nasopharyngeal carcinoma is associated with a 5 year survival rate of 65%. The common complications of nasopharyngeal carcinoma include airway obstruction, dysphagia and disfigurement of the neck or face.
Natural History
- If left untreated nasopharyngeal carcinoma produces few symptoms early in its course.
- Once the tumor has expanded from its site of origin in the lateral wall of the nasopharynx, it may obstruct the nasal passages and cause nasal discharge or epistaxis.
Complications
Complications of nasopharyngeal carcinoma include:
- Airway obstruction
- Difficulty swallowing
- Disfigurement of the neck or face
- Hardening of the skin of the neck
- Loss of voice and speaking ability
- Metastasis
Potential complications of radiotherapy include:
- Radiation necrosis of the temporal lobes
- Cranial nerve dysfunction
- Atrophy and fibrosis of the muscles of mastication
Prognosis
Non-keratinizing nasopharyngeal carcinoma is associated with a 5 year survival rate of 65%.[1] Prognosis is influenced by tumor type:
- Type I: Keratinizing squamous cell carcinoma - 42% 5 year survival
- Type II: Non-keratinizing squamous cell carcinoma - 65% 5 year survival
- Type III: Undifferentiated carcinoma - 14% 5 year survival[2]
References
- ↑ Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor). Modern Surgical Pathology (2 Volume Set). London: W B Saunders. ISBN 0-7216-7253-1.
- ↑ http://radiopaedia.org/articles/nasopharyngeal-carcinoma