Gliomatosis cerebri pathophysiology: Difference between revisions
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*Gliomatosis cerebri may be classified into primary (''de novo'') or secondary, with the latter as a result from the spreading of a more focal [[glioma]]. | *Gliomatosis cerebri may be classified into primary (''de novo'') or secondary, with the latter as a result from the spreading of a more focal [[glioma]]. | ||
*According to WHO classification of brain tumors, gliomatosis cerebri is classified into grade 2 or grade 3 tumors. | *According to WHO classification of brain tumors, gliomatosis cerebri is classified into grade 2 or grade 3 tumors. | ||
===Genetics=== | |||
Genes involved in pathogenesis of gliomatosis cerebri include:<ref name="pmid20223351">{{cite journal| author=San Millan B, Kaci R, Polivka M, Robert G, Héran F, Gueguen A et al.| title=[Gliomatosis cerebri: a biopsy and autopsy case report]. | journal=Ann Pathol | year= 2010 | volume= 30 | issue= 1 | pages= 25-9 | pmid=20223351 | doi=10.1016/j.annpat.2009.10.020 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20223351 }} </ref> | |||
*''[[p53]]'' | |||
*''[[OLIG-2]]'' | |||
*''[[Ki-67]]'' | |||
===Associated Conditions=== | ===Associated Conditions=== | ||
Revision as of 13:48, 25 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Pathophysiology
Pathogenesis
- Gliomatosis cerebri may be classified into primary (de novo) or secondary, with the latter as a result from the spreading of a more focal glioma.
- According to WHO classification of brain tumors, gliomatosis cerebri is classified into grade 2 or grade 3 tumors.
Genetics
Genes involved in pathogenesis of gliomatosis cerebri include:[1]
Associated Conditions
Gliomatosis cerebri may be associated with:[2]
Gross Pathology
On gross pathology, gliomatosis cerebri is characterized by:[2]
- Diffuse, usually astrocytic growth pattern
- Involves at least three cerebral lobes
- Bilateral involvement of the cerebral hemispheres, deep gray matter, brainstem, or cerebellum
References
- ↑ San Millan B, Kaci R, Polivka M, Robert G, Héran F, Gueguen A; et al. (2010). "[Gliomatosis cerebri: a biopsy and autopsy case report]". Ann Pathol. 30 (1): 25–9. doi:10.1016/j.annpat.2009.10.020. PMID 20223351.
- ↑ 2.0 2.1 Buis DR, van der Valk P, De Witt Hamer PC (2012). "Subcutaneous tumor seeding after biopsy in gliomatosis cerebri". J Neurooncol. 106 (2): 431–5. doi:10.1007/s11060-011-0678-2. PMC 3230756. PMID 21837541.