Insulinoma pathophysiology: Difference between revisions
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On microscopic histopathological analysis characteristic findings of insulinoma are: | On microscopic histopathological analysis characteristic findings of insulinoma are: | ||
*Solid or gyriform patterns, usually without glands | *Solid or gyriform patterns, usually without glands | ||
*Endocrine cells in insulinoma are organised in nests and trabecular pattern scattered throughout a fibro-vascular stroma with well-localised fibrous septa separating it from normal tissue<ref name=" | *Endocrine cells in insulinoma are organised in nests and trabecular pattern scattered throughout a fibro-vascular stroma with well-localised fibrous septa separating it from normal tissue<ref name="PadidelaFiest2014">{{cite journal|last1=Padidela|first1=R.|last2=Fiest|first2=M.|last3=Arya|first3=V.|last4=Smith|first4=V. V.|last5=Ashworth|first5=M.|last6=Rampling|first6=D.|last7=Newbould|first7=M.|last8=Batra|first8=G.|last9=James|first9=J.|last10=Wright|first10=N. B.|last11=Dunne|first11=M. J.|last12=Clayton|first12=P. E.|last13=Banerjee|first13=I.|last14=Hussain|first14=K.|title=Insulinoma in childhood: clinical, radiological, molecular and histological aspects of nine patients|journal=European Journal of Endocrinology|volume=170|issue=5|year=2014|pages=741–747|issn=0804-4643|doi=10.1530/EJE-13-1008}}</ref> | ||
*Absence of exocrine tissue with the loss of normal pancreatic architecture | *Absence of exocrine tissue with the loss of normal pancreatic architecture | ||
Revision as of 19:11, 1 October 2015
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Insulinoma Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Pathophysiology
Genetics
- Insulinoma can occur in association with inherited syndrome, such as multiple endocrine neoplasia type 1 von Hippel-Landau syndrome or sporadic.[1]
- Multiple endocrine neoplasia type 1 is an autosomal dominant disorder caused by alterations of the MEN1 gene located at chromosomal region 11q13.
- Approximately 10% of insulinomas are multiple and 10% malignant.[2]
Microscopic Pathology
On microscopic histopathological analysis characteristic findings of insulinoma are:
- Solid or gyriform patterns, usually without glands
- Endocrine cells in insulinoma are organised in nests and trabecular pattern scattered throughout a fibro-vascular stroma with well-localised fibrous septa separating it from normal tissue[3]
- Absence of exocrine tissue with the loss of normal pancreatic architecture
-
![Histopathology of pancreatic endocrine tumor (insulinoma). H&E stain[4]](/images/2/2d/Pancreatic_insulinoma_Histology_1.JPG)
Histopathology of pancreatic endocrine tumor (insulinoma). H&E stain[4] -
![Histopathology of pancreatic endocrine tumor (insulinoma)[4]](/images/2/2f/Pancreatic_insulinoma_histology_2.JPG)
Histopathology of pancreatic endocrine tumor (insulinoma)[4] -
![Histopathology of pancreatic endocrine tumor (insulinoma). Chromogranin A immunostain[4]](/images/a/a3/Pancreatic_insulinoma_histopathology_3.JPG)
Histopathology of pancreatic endocrine tumor (insulinoma). Chromogranin A immunostain[4] -
![Histopathology of pancreatic endocrine tumor (insulinoma). Insulin immunostain[4]](/images/d/d5/Pancreatic_insulinoma_histology_4.JPG)
Histopathology of pancreatic endocrine tumor (insulinoma). Insulin immunostain[4]
![Histopathology of pancreatic endocrine tumor (insulinoma). H&E stain[4]](/index.php/File:Pancreatic_insulinoma_Histology_1.JPG)
![Histopathology of pancreatic endocrine tumor (insulinoma)[4]](/index.php/File:Pancreatic_insulinoma_histology_2.JPG)
![Histopathology of pancreatic endocrine tumor (insulinoma). Chromogranin A immunostain[4]](/index.php/File:Pancreatic_insulinoma_histopathology_3.JPG)
![Histopathology of pancreatic endocrine tumor (insulinoma). Insulin immunostain[4]](/index.php/File:Pancreatic_insulinoma_histology_4.JPG)
References
- ↑ Murray PD, McKenzie DT, Swain SL, Kagnoff MF (1987). "Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression". J Immunol. 139 (8): 2669–74. PMID 3498768.
- ↑ Insulinoma. Dr Yuranga Weerakkody and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/insulinoma
- ↑ Padidela, R.; Fiest, M.; Arya, V.; Smith, V. V.; Ashworth, M.; Rampling, D.; Newbould, M.; Batra, G.; James, J.; Wright, N. B.; Dunne, M. J.; Clayton, P. E.; Banerjee, I.; Hussain, K. (2014). "Insulinoma in childhood: clinical, radiological, molecular and histological aspects of nine patients". European Journal of Endocrinology. 170 (5): 741–747. doi:10.1530/EJE-13-1008. ISSN 0804-4643.
- ↑ 4.0 4.1 4.2 4.3 Neuroendocrine tumour of the pancreas. Libre Pathology. http://librepathology.org/wiki/index.php/Neuroendocrine_tumour_of_the_pancreas