Insulinoma medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
==Non-surgical Options== | ==Non-surgical Options== | ||
*Octreotide | |||
*Endoscopic ultrasound guided alcohol ablation | |||
*Radiofrequency ablation (RFA) | |||
*Embolization | |||
*Diazoxide | |||
*Chemotherapy | |||
Medications such as [[diazoxide]] and [[somatostatin]] can be used to block the release of insulin for patients who are not surgical candidates or who otherwise have inoperable tumours.<br/> | Medications such as [[diazoxide]] and [[somatostatin]] can be used to block the release of insulin for patients who are not surgical candidates or who otherwise have inoperable tumours.<br/> | ||
[[Streptozotocin]] is used in [[islet cell carcinoma]]s which produce excessive insulin. Combination [[chemotherapy]] is used: either [[doxorubicin]] + streptozotocin, or [[fluorouracil]] + streptotozocin in patients where doxorubicin is contraindicated.[http://www.cancer.gov/cancertopics/pdq/treatment/isletcell/HealthProfessional/page6] <br> | [[Streptozotocin]] is used in [[islet cell carcinoma]]s which produce excessive insulin. Combination [[chemotherapy]] is used: either [[doxorubicin]] + streptozotocin, or [[fluorouracil]] + streptotozocin in patients where doxorubicin is contraindicated.[http://www.cancer.gov/cancertopics/pdq/treatment/isletcell/HealthProfessional/page6] <br> | ||
Revision as of 19:16, 6 October 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
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Risk calculators and risk factors for Insulinoma medical therapy |
Overview
Non-surgical Options
- Octreotide
- Endoscopic ultrasound guided alcohol ablation
- Radiofrequency ablation (RFA)
- Embolization
- Diazoxide
- Chemotherapy
Medications such as diazoxide and somatostatin can be used to block the release of insulin for patients who are not surgical candidates or who otherwise have inoperable tumours.
Streptozotocin is used in islet cell carcinomas which produce excessive insulin. Combination chemotherapy is used: either doxorubicin + streptozotocin, or fluorouracil + streptotozocin in patients where doxorubicin is contraindicated.[3]
In metastasizing tumours with intrahepatic growth, hepatic arterial occlusion or embolization can be used. [4]