Insulinoma epidemiology and demographics: Difference between revisions
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*Estimates of malignancy (metastases) range from 5% to 30%. | *Estimates of malignancy (metastases) range from 5% to 30%. | ||
*Over 99% of insulinomas originate in the pancreas, with rare cases from ectopic pancreatic tissue. | *Over 99% of insulinomas originate in the pancreas, with rare cases from ectopic pancreatic tissue. | ||
*About 5% of cases are associated with tumors of the [[parathyroid glands]], [[pituitary]], | *About 5% of cases are associated with tumors of the [[parathyroid glands]], [[pituitary]], or [[Multiple endocrine neoplasia type 1]] and are more likely to be multiple and malignant. | ||
*Most insulinomas are small, less than 2 cm. | *Most insulinomas are small, less than 2 cm. | ||
===Age=== | ===Age=== | ||
*The median age at diagnosis is 45.5 years.<ref name="pmid15575328">{{cite journal| author=Vázquez Quintana E| title=The surgical management of insulinoma. | journal=Bol Asoc Med P R | year= 2004 | volume= 96 | issue= 1 | pages= 33-8 | pmid=15575328 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15575328 }} </ref> | *The median age at diagnosis is 45.5 years.<ref name="pmid15575328">{{cite journal| author=Vázquez Quintana E| title=The surgical management of insulinoma. | journal=Bol Asoc Med P R | year= 2004 | volume= 96 | issue= 1 | pages= 33-8 | pmid=15575328 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15575328 }} </ref> | ||
Revision as of 21:17, 7 October 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
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Overview
The incidence of insulinoma is approximately 0.1 to 0.4 per 100,000 individuals worldwide. There is no racial predilection to the insulinoma. Females are more commonly affected with insulinoma than males.[1] The male to female ratio is approximately 2 to 3. The median age at diagnosis is 45.5 years.[1]
Epidemiology and Demographics
Incidence
- Insulinomas are rare neuroendocrine tumors with an incidence estimated at 1 to 4 new cases per million persons per year.
- Insulinoma is one of the most common types of tumor arising from the islets of Langerhans cells (pancreatic endocrine tumors).
- Estimates of malignancy (metastases) range from 5% to 30%.
- Over 99% of insulinomas originate in the pancreas, with rare cases from ectopic pancreatic tissue.
- About 5% of cases are associated with tumors of the parathyroid glands, pituitary, or Multiple endocrine neoplasia type 1 and are more likely to be multiple and malignant.
- Most insulinomas are small, less than 2 cm.
Age
- The median age at diagnosis is 45.5 years.[1]
Gender
- Females are more commonly affected with insulinoma than males.[1]
- The male to female ratio is approximately 2 to 3.
Race
- There is no racial predilection to the insulinoma.