Insulinoma medical therapy: Difference between revisions
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Medications such as [[diazoxide]] and [[somatostatin]] can be used to block the release of insulin for patients who are not surgical candidates or who otherwise have inoperable tumors. | Medications such as [[diazoxide]] and [[somatostatin]] can be used to block the release of insulin for patients who are not surgical candidates or who otherwise have inoperable tumors. | ||
[[Streptozotocin]] is used in [[islet cell carcinoma]]s which produce excessive insulin. Combination [[chemotherapy]] is used: either [[doxorubicin]] + streptozotocin, or [[fluorouracil]] + streptotozocin in patients where [[doxorubicin]] is contraindicated.<ref>[http://www.cancer.gov/cancertopics/pdq/treatment/isletcell/HealthProfessional/page6]</ref> | [[Streptozotocin]] is used in [[islet cell carcinoma]]s which produce excessive insulin. Combination [[chemotherapy]] is used: either [[doxorubicin]] + streptozotocin, or [[fluorouracil]] + streptotozocin in patients where [[doxorubicin]] is contraindicated.<ref>[http://www.cancer.gov/cancertopics/pdq/treatment/isletcell/HealthProfessional/page6]</ref> | ||
In metastasizing tumours with intrahepatic growth, [[hepatic artery|hepatic arterial]] occlusion or [[embolization]] can be used. <ref>[http://www.nci.nih.gov/cancertopics/pdq/treatment/isletcell/Patient/page5]</ref> | In metastasizing tumours with intrahepatic growth, [[hepatic artery|hepatic arterial]] occlusion or [[embolization]] can be used.<ref>[http://www.nci.nih.gov/cancertopics/pdq/treatment/isletcell/Patient/page5]</ref> | ||
==References== | ==References== | ||
Revision as of 23:16, 7 October 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [4]
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Overview
The predominant therapy for insulinoma is surgical resection. Supportive therapy for insulinoma includes octerotide, endoscopic ultrasound guided alcohol ablation, radiofrequency ablation, embolization, diazoxide and chemotherapy.
Medical Therapy
The medical therapy of insulinoma include:[1]
- Octreotide
- Endoscopic ultrasound guided alcohol ablation
- Radiofrequency ablation (RFA)
- Embolization
- Diazoxide
- Chemotherapy
Medications such as diazoxide and somatostatin can be used to block the release of insulin for patients who are not surgical candidates or who otherwise have inoperable tumors. Streptozotocin is used in islet cell carcinomas which produce excessive insulin. Combination chemotherapy is used: either doxorubicin + streptozotocin, or fluorouracil + streptotozocin in patients where doxorubicin is contraindicated.[2] In metastasizing tumours with intrahepatic growth, hepatic arterial occlusion or embolization can be used.[3]
References