Testicular cancer medical therapy: Difference between revisions
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==Medical Therapy== | ==Medical Therapy== | ||
===Radiation therapy=== | ===Radiation therapy=== | ||
* Radiation therapy works best for seminomas. Non-seminomas do not respond well to radiation therapy. | * [[Radiation therapy]] works best for seminomas. Non-seminomas do not respond well to radiation therapy. | ||
* External beam radiation may be used for stage I and II seminomas after | * [[External beam radiotherapy|External beam radiation]] may be used for stage I and II seminomas after [[orchiectomy]].<ref>Testicular cancer.2015 Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/?region=ab </ref> | ||
* Radiation treatments are usually given once a day, 5 days a week, for 2–4 weeks. | * Radiation treatments are usually given once a day, 5 days a week, for 2–4 weeks. | ||
===Chemotherapy=== | ===Chemotherapy=== | ||
'''Standard-dose chemotherapy'''<ref>Testicular cancer.2015 Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/?region=ab </ref> | '''Standard-dose chemotherapy'''<ref>Testicular cancer.2015 Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/?region=ab </ref> | ||
* The most common chemotherapy combinations used to treat testicular cancer are: | * The most common [[chemotherapy]] combinations used to treat testicular cancer are: | ||
:* | :* [[Bleomycin]], [[etoposide]] and [[cisplatin]] | ||
:* | ::* It is usually given IV every 3 weeks for 2–3 months, or 3 or 4 cycles. In some cases, 1 or 2 cycles may be given for stage I non-seminomas. | ||
:* | :* [[Etoposide]] and [[cisplatin]] | ||
::* It is used when bleomycin affects the lungs or there is a high risk that it will cause lung damage. It is given IV every 3 weeks for 3 months, or 4 cycles. | |||
:* Etoposide, [[ifosfamide]] and cisplatin | |||
::* It may be used when bleomycin affects the lungs or there is a high risk that it will cause lung damage. It is given IV every 3 weeks for 3 months, or 4 cycles. | |||
* If testicular cancer doesn’t respond to the above drugs or if it recurs, the following chemotherapy combinations may be used. These are sometimes called salvage, or second-line, chemotherapy. | * If testicular cancer doesn’t respond to the above drugs or if it recurs, the following chemotherapy combinations may be used. These are sometimes called salvage, or second-line, chemotherapy. | ||
:* | :* [[Paclitaxel]], ifosfamide and cisplatin | ||
:* | ::* It is given IV every 3 weeks for 3 months, or 4 cycles. | ||
:* | :* Etoposide, ifosfamide and cisplatin. | ||
::* It is given IV every 3 weeks for 3 months, or 4 cycles. | |||
:* Etoposide or [[vinblastine]], ifosfamide and cisplatin | |||
::* It is given IV every 3 weeks for 3 months, or 4 cycles. | |||
'''High-dose chemotherapy''' | '''High-dose chemotherapy''' | ||
* High-dose chemotherapy with carboplatin and etoposide may be used if testicular cancer recurs after it is treated with standard-dose chemotherapy. | * High-dose chemotherapy with [[carboplatin]] and [[etoposide]] may be used if testicular cancer recurs after it is treated with standard-dose chemotherapy. | ||
'''Palliative chemotherapy''' | '''Palliative chemotherapy''' | ||
* Palliative therapy is given to relieve symptoms, rather than to treat the cancer itself. Gemcitabine | * Palliative therapy is given to relieve symptoms, rather than to treat the cancer itself. [[Gemcitabine]] may be given with [[oxaliplatin]], [[paclitaxel]] or both as palliative treatment for seminomas or non-seminomas. | ||
==References== | ==References== | ||
Revision as of 02:39, 17 October 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Medical Therapy
Radiation therapy
- Radiation therapy works best for seminomas. Non-seminomas do not respond well to radiation therapy.
- External beam radiation may be used for stage I and II seminomas after orchiectomy.[1]
- Radiation treatments are usually given once a day, 5 days a week, for 2–4 weeks.
Chemotherapy
Standard-dose chemotherapy[2]
- The most common chemotherapy combinations used to treat testicular cancer are:
-
- It is usually given IV every 3 weeks for 2–3 months, or 3 or 4 cycles. In some cases, 1 or 2 cycles may be given for stage I non-seminomas.
- It is used when bleomycin affects the lungs or there is a high risk that it will cause lung damage. It is given IV every 3 weeks for 3 months, or 4 cycles.
- Etoposide, ifosfamide and cisplatin
- It may be used when bleomycin affects the lungs or there is a high risk that it will cause lung damage. It is given IV every 3 weeks for 3 months, or 4 cycles.
- If testicular cancer doesn’t respond to the above drugs or if it recurs, the following chemotherapy combinations may be used. These are sometimes called salvage, or second-line, chemotherapy.
- Paclitaxel, ifosfamide and cisplatin
- It is given IV every 3 weeks for 3 months, or 4 cycles.
- Etoposide, ifosfamide and cisplatin.
- It is given IV every 3 weeks for 3 months, or 4 cycles.
- Etoposide or vinblastine, ifosfamide and cisplatin
- It is given IV every 3 weeks for 3 months, or 4 cycles.
High-dose chemotherapy
- High-dose chemotherapy with carboplatin and etoposide may be used if testicular cancer recurs after it is treated with standard-dose chemotherapy.
Palliative chemotherapy
- Palliative therapy is given to relieve symptoms, rather than to treat the cancer itself. Gemcitabine may be given with oxaliplatin, paclitaxel or both as palliative treatment for seminomas or non-seminomas.
References
- ↑ Testicular cancer.2015 Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/?region=ab
- ↑ Testicular cancer.2015 Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/?region=ab